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Csrp1 Gene Detail
Summary
  • Symbol
    Csrp1
  • Name
    cysteine and glycine-rich protein 1
  • Synonyms
    CRP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88549
    NCBI Gene: 13007
  • Gene Overview
    MyGene.info: CSRP1
Location & Maps
more
  • Sequence Map
    Chr1:135720061-135752232 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32172 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CSRP1, cysteine and glycine rich protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CSRP1, cysteine and glycine rich protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRP, CRP1, CSRP, CYRP, D1S181E, HEL-141, HEL-S-286
  • Links
    NCBI Gene ID: 1465
    neXtProt AC: NX_P21291

  • Chr Location
    1q32; chr1:201483530-201507259 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37874
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: CSRP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    3 involving Csrp1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased neointima formation following wire-induced arterial injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021802 VEGA Gene Model | MGI Sequence Detail 32172 C57BL/6J ±  kb
transcript OTTMUST00000051742 VEGA | MGI Sequence Detail 1828 Not Applicable  
polypeptide OTTMUSP00000024413 VEGA | MGI Sequence Detail 193 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    504 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005958 cysteine and glycine-rich protein 1
  • InterPro Domains
    IPR001781 Zinc finger, LIM-type
Molecular
Reagents
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  • All nucleic 371
    cDNA 368
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-2207, MGI:1353622, MGI:2138134, MGI:2138600
References
more
  • Summaries
    All 50
    Developmental Gene Expression 12
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:823 Wang X, et al., Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc. J Biol Chem. 1992 May 5;267(13):9176-84
  • Latest
    J:217538 Lui JH, et al., Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex. Nature. 2014 Nov 13;515(7526):264-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory