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Csnk2b Gene Detail
Summary
  • Symbol
    Csnk2b
  • Name
    casein kinase 2, beta polypeptide
  • Feature Type
    protein coding gene
  • IDs
    MGI:88548
    NCBI Gene: 13001
  • Gene Overview
    MyGene.info: CSNK2B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:35116196-35122053 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5858 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CSNK2B, casein kinase 2 beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CSNK2B, casein kinase 2 beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CK2B, CK2N, Ckb1, Ckb2, CSK2B, G5A
  • Links
    NCBI Gene ID: 1460
    neXtProt AC: NX_P67870
    UniProt: P67870

  • Chr Location
    6p21.33; chr6:31665880-31670070 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit embryonic lethality post-implantation, growth retardation and arrest, a failure to form an inner cell mass and smaller size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037175 VEGA Gene Model | MGI Sequence Detail 5858 C57BL/6J ±  kb
    transcript OTTMUST00000095775 VEGA | MGI Sequence Detail 883 Not Applicable  
    polypeptide OTTMUSP00000053462 VEGA | MGI Sequence Detail 257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 206
      Genomic 9
      cDNA 196
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2206
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:10587 Kopatz I, et al., The nucleotide sequence of the mouse cDNA encoding the beta subunit of casein kinase II. Nucleic Acids Res. 1990 Jun 25;18(12):3639
    • Latest
      J:262171 Munzer P, et al., CK2beta regulates thrombopoiesis and Ca(2+)-triggered platelet activation in arterial thrombosis. Blood. 2017 Dec 21;130(25):2774-2785

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory