Csnk2a1
Gene Detail

Symbol Name ID

Csnk2a1 casein kinase 2, alpha 1 polypeptide MGI:88543

Synonyms

Csnk2a1-rs4

Feature Type

protein coding gene

Genetic Map

Chromosome 2

74.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:152226839-152281852 bp, + strand From VEGA annotation of GRCm38   55014 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:90874  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Csnk2a1

Human homologs

Human Homolog		CSNK2A1, casein kinase 2, alpha 1 polypeptide
NCBI Gene ID		1457
neXtProt AC		NX_P68400
Human Synonyms		CK2A1, CKII
Human Chr (Location)		20p13; chr20:463338-524482 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(85) : Targeted(4) Gene trapped(81)
 

Mice homozygous for the null in the major catalytic subunit die by E11.5 and exhibit defects in neural, cardiac and limb development.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	apoptotic process, cell cycle, ...
Component	nucleus, NuRD complex, ...
Function	ATP binding, beta-catenin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (313)    Tissues (239)    Images (33)
Theiler Stages: 11, 13, 17, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	37
RNA in situ	230
RT-PCR	46

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(3) cDNA(24) Primer pair(2)
Microarray probesets(11)

Other database links

VEGA Gene Model	OTTMUSG00000015858 (Evidence)
Ensembl Gene Model	ENSMUSG00000074698 (Evidence)
Entrez Gene	12995 (Evidence)
DFCI	TC1574149, TC1589511, TC1658918, TC1674920, TC1687972
DoTS	DT.101186575, DT.101312944, DT.101380074, DT.531953, DT.533604, DT.94290322
NIA Mouse Gene Index	U000951, U042384
EC	2.7.11.1
Consensus CDS Project	CCDS16879.1
International Mouse Knockout Project Status	Csnk2a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015858	VEGA Gene Model | MGI Sequence Detail	55014	C57BL/6J
transcript	OTTMUST00000037681	VEGA | MGI Sequence Detail	4206	Not Applicable
polypeptide	OTTMUSP00000016898	VEGA | MGI Sequence Detail	391	Not Applicable

All sequences(62) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(117 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000005950	casein kinase II subunit alpha

References

(Earliest) J:2617 Yang-Feng TL, et al., Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. Nucleic Acids Res. 1991 Dec;19(25):7125-9
(Latest) J:190725 Iyengar AS, et al., Identification of CK2 as the kinase that phosphorylates Pax3 at Ser209 in early myogenic differentiation. Biochem Biophys Res Commun. 2012 Nov 9;428(1):24-30
All references(64)

Other accession IDs

MGD-MRK-2201, MGI:894650