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Csnk2a1 Gene Detail
Summary
  • Symbol
    Csnk2a1
  • Name
    casein kinase 2, alpha 1 polypeptide
  • Synonyms
    CK2, Csnk2a1-rs4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88543
    NCBI Gene: 12995
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:152226839-152281852 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55014 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CSNK2A1, casein kinase 2 alpha 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CSNK2A1, casein kinase 2 alpha 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CK2A1, Cka1, Cka2, CKII, OCNDS
  • Links
    NCBI Gene ID: 1457
    neXtProt AC: NX_P68400
    UniProt: P68400

  • Chr Location
    20p13; chr20:482694-543838 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for the null in the major catalytic subunit die by E11.5 and exhibit defects in neural, cardiac and limb development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015858 VEGA Gene Model | MGI Sequence Detail 55014 C57BL/6J ±  kb
    transcript OTTMUST00000037681 VEGA | MGI Sequence Detail 4206 Not Applicable  
    polypeptide OTTMUSP00000016898 VEGA | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      126 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 125
      Genomic 3
      cDNA 120
      Primer pair 2

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-2201, MGI:894650
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 14
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:251209 Cortes M, et al., CK2 Oppositely Modulates l-DOPA-Induced Dyskinesia via Striatal Projection Neurons Expressing D1 or D2 Receptors. J Neurosci. 2017 Dec 6;37(49):11930-11946

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory