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Csnk2a1
Gene Detail
Symbol

Name
ID
Csnk2a1
casein kinase 2, alpha 1 polypeptide
MGI:88543
Synonyms
Csnk2a1-rs4
Feature Type
protein coding gene
Genetic Map
Chromosome 2
74.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:152226839-152281852 bp, + strand
From VEGA annotation of GRCm38

  55014 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:90874  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Csnk2a1

Human
homologs
Human Homolog CSNK2A1, casein kinase 2, alpha 1 polypeptide
NCBI Gene ID 1457
neXtProt AC  NX_P68400
Human Synonyms  CK2A1, CKII, CSNK2A3
Human Chr (Location)  20p13; chr20:473322-543838 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(85) : Gene trapped(81) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for the null in the major catalytic subunit die by E11.5 and exhibit defects in neural, cardiac and limb development.
 
Interactions
Csnk2a1 interacts with 378 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process apoptotic process, cell cycle, ...
Component nucleus, NuRD complex, ...
Function ATP binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (313)    Tissues (240)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 37
RNA in situ 230
RT-PCR 46
cDNA source data(117)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(124) Genomic(3) cDNA(119) Primer pair(2)
Microarray probesets(11)
Other database
links
VEGA Gene ModelOTTMUSG00000015858 (Evidence)
Ensembl Gene ModelENSMUSG00000074698 (Evidence)
Entrez Gene12995 (Evidence)
UniGene23692
DFCITC1574149, TC1589511, TC1658918, TC1674920, TC1687972
DoTSDT.101186575, DT.101312944, DT.101380074, DT.531953, DT.533604, DT.94290322
NIA Mouse Gene IndexU000951, U042384
EC2.7.11.1
Consensus CDS ProjectCCDS16879.1
International Mouse Knockout Project StatusCsnk2a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015858 VEGA Gene Model | MGI Sequence Detail 55014 C57BL/6J ±  kb
transcript OTTMUST00000037681 VEGA | MGI Sequence Detail 4206 Not Applicable 
polypeptide OTTMUSP00000016898 VEGA | MGI Sequence Detail 391 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005950 casein kinase II subunit alpha
References
(Earliest) J:2617 Yang-Feng TL, et al., Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. Nucleic Acids Res. 1991 Dec;19(25):7125-9
(Latest) J:203719 Umemura Y, et al., An in vitro ES cell-based clock recapitulation assay model identifies CK2alpha as an endogenous clock regulator. PLoS One. 2013;8(6):e67241
All references(66)
Other
accession IDs
MGD-MRK-2201, MGI:894650

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory