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Csn2 Gene Detail
Summary
  • Symbol
    Csn2
  • Name
    casein beta
  • Synonyms
    CSN2, Csnb
  • Feature Type
    protein coding gene
  • IDs
    MGI:88541
    NCBI Gene: 12991
  • Member of
    Csn cluster
  • Gene Overview
    MyGene.info: CSN2
Location & Maps
more
  • Sequence Map
    Chr5:87692624-87699630 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7007 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 43.56 cM
  • Mapping Data
    20 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    CSN2, casein beta
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CSN2, casein beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CASB
  • Links
    NCBI Gene ID: 1447
    neXtProt AC: NX_P05814

  • Chr Location
    4q13.3; chr4:69955256-69993629 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    4 involving Csn2
  • Incidental Mutations
Female mice homozygous for disruption of this gene produce mile with a low protein content and poor nutritional value.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054071 VEGA Gene Model | MGI Sequence Detail 7007 C57BL/6J ±  kb
transcript OTTMUST00000134358 VEGA | MGI Sequence Detail 1329 Not Applicable  
polypeptide OTTMUSP00000071257 VEGA | MGI Sequence Detail 231 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    57 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2294
    Genomic 15
    cDNA 2273
    Primer pair 3
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-2199
References
more
  • Summaries
    All 58
    Developmental Gene Expression 9
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:6738 Gupta P, et al., Localization of the casein gene family to a single mouse chromosome. J Cell Biol. 1982 Apr;93(1):199-204
  • Latest
    J:184505 Oliver CH, et al., The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev. 2012 May 15;26(10):1086-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory