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Csn2
Gene Detail
 Symbol
Name
ID
Member of
Csn2
casein beta
MGI:88541
Csn cluster
STS D5Mit12, D5Mit16
Synonyms CSN2, Csnb
Feature Type protein coding gene
Genetic Map
Chromosome 5
43.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr5:87692624-87699421 bp, - strand
From NCBI annotation of GRCm38

  6798 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: beta-casein
Gene Tree: Csn2

Human
homologs
Human Homolog CSN2, casein beta
NCBI Gene ID 1447
neXtProt AC  NX_P05814
Human Synonyms  CASB
Human Chr (Location)  4q21.1; chr4:69955256-69961008 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Female mice homozygous for disruption of this gene produce mile with a low protein content and poor nutritional value.
 
Interactions
Csn2 interacts with 98 markers (Mir18, Mir18b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process lactation, transport
Component extracellular region, extracellular space
Function transporter activity
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 46
cDNA source data(2271)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(2293) Genomic(15) cDNA(2273) Primer pair(3) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000063157 (Evidence)
Entrez Gene12991 (Evidence)
UniGene268737
DFCITC1573617, TC1602218, TC1616428
DoTSDT.101233788, DT.101339325, DT.101365818, DT.91391979, DT.91399695, DT.91431341, DT.91556257, DT.91565593, DT.91601428, DT.94124126, DT.94157838, DT.97395835, DT.97396144
NIA Mouse Gene IndexU026367
Consensus CDS ProjectCCDS39131.1
International Mouse Knockout Project StatusCsn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12991 NCBI Gene Model | MGI Sequence Detail 6798 C57BL/6J ±  kb
transcript NM_001286021 RefSeq | MGI Sequence Detail 1141 C57BL/6 
polypeptide P10598 UniProt | EBI | MGI Sequence Detail 231 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(13) UniProt(3)
Polymorphisms All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001588 Casein, alpha/beta
InterPro IPR016345 Casein, beta
Protein Ontology PR:000005941 beta-casein
Graphical View of Protein Domain Structure
References (Earliest) J:6738 Gupta P, et al., Localization of the casein gene family to a single mouse chromosome. J Cell Biol. 1982 Apr;93(1):199-204
(Latest) J:184505 Oliver CH, et al., The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev. 2012 May 15;26(10):1086-97
All references(64)
Other
accession IDs
MGD-MRK-2199

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory