Csn1s1 MGI Mouse Gene Detail - MGI:88540

Symbol

Csn1s1
Name

casein alpha s1
Synonyms

Csna

Feature Type

protein coding gene
IDs

MGI:88540
NCBI Gene: 12990
Member of

Csn cluster
Gene Overview

MyGene.info: CSN1S1
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr5:87666208-87682578 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 43.56 cM
Mapping Data

14 experiments

SNPs within 2kb

156 from dbSNP Build 142
Strain Annotations

17
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88540	protein coding gene	Chr5:87666208-87682578 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029689	protein coding gene	Chr5:88617264-88634561 (+)
A/J	MGP_AJ_G0029656	protein coding gene	Chr5:85000275-85016645 (+)
AKR/J	MGP_AKRJ_G0029602	protein coding gene	Chr5:87813605-87829985 (+)
BALB/cJ	MGP_BALBcJ_G0029665	protein coding gene	Chr5:85908051-85926469 (+)
C3H/HeJ	MGP_C3HHeJ_G0029388	protein coding gene	Chr5:88226610-88243827 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030120	protein coding gene	Chr5:92255492-92274510 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027358	protein coding gene	Chr5:80627295-80643223 (+)
CAST/EiJ	MGP_CASTEiJ_G0028798	protein coding gene	Chr5:87584611-87603410 (+)
CBA/J	MGP_CBAJ_G0029357	protein coding gene	Chr5:95155299-95177180 (+)
DBA/2J	MGP_DBA2J_G0029502	protein coding gene	Chr5:85178424-85194454 (+)
FVB/NJ	MGP_FVBNJ_G0029462	protein coding gene	Chr5:84087850-84105711 (+)
LP/J	MGP_LPJ_G0029590	protein coding gene	Chr5:89026235-89044964 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0030153	protein coding gene	Chr5:87377467-87395328 (+)
PWK/PhJ	MGP_PWKPhJ_G0028517	protein coding gene	Chr5:84158304-84176826 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028355	protein coding gene	Chr5:86831898-86849012 (+)
WSB/EiJ	MGP_WSBEiJ_G0028877	protein coding gene	Chr5:87768109-87785790 (+)

Human Ortholog

CSN1S1, casein alpha s1

Human Ortholog

CSN1S1, casein alpha s1
Orthology source: HGNC
Synonyms

CASA, CSN1
Links

HGNC:2445

NCBI Gene ID: 1446

neXtProt AC: NX_P47710

UniProt: P47710
Chr Location

4q13.3; chr4:69931062-69946570 (+) GRCh38.p7

HCOP

human homology predictions: CSN1S1
Protein SuperFamily

alpha-s1-casein
Gene Tree

Csn1s1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Radiation induced

1
Spontaneous

1
Targeted

1
Genomic Mutations

4 involving Csn1s1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

0 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display reduced milk prodution and abnormal milk composition with reduced protein, calcium and phosphate concentrations.

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All GO Annotations

6
GO References

2

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

677
Tissues

45
cDNA Data

1900
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Csn1s1 interacts with 86 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

66
RefSeq

6
UniProt

7
CCDS

CCDS51534.1, CCDS80314.1
UniGene

427467

Ensembl

ENSMUSG00000070702 (Evidence)
NCBI Gene

12990

			Length	Strain/Species	Flank
genomic	12990	NCBI Gene Model \| MGI Sequence Detail	16371	C57BL/6J	± kb
transcript	NM_007784	RefSeq \| MGI Sequence Detail	1466	C57BL/6
polypeptide	P19228	UniProt \| EBI \| MGI Sequence Detail	313	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000005940 alpha-S1-casein

(term hierarchy)
InterPro Domains

IPR026999 Alpha-s1 casein

IPR001588 Casein, alpha/beta

IPR031305 Casein alpha/beta, conserved site

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All nucleic 1913

Genomic 7

cDNA 1903

Primer pair 1

Other 2

Microarray probesets 3

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MGD-MRK-2198, MGI:2140790, MGI:2141176

Summaries

All 47

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 7
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:237813 Chen JQ, et al., Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent. PLoS One. 2015;10(6):e0129895

TSS for Csn1s1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46861	Chr5:87666200-87666218 (+)	1 bp
Tssr46862	Chr5:87666965-87666976 (+)	763 bp
Tssr46863	Chr5:87667226-87667237 (+)	1,024 bp
Tssr46864	Chr5:87667243-87667258 (+)	1,043 bp
Tssr1524	Chr5:87670882-87670897 (+)	4,682 bp
Tssr46869	Chr5:87670998-87671016 (+)	4,799 bp
Tssr46874	Chr5:87677029-87677031 (+)	10,822 bp
Tssr46875	Chr5:87677588-87677621 (+)	11,397 bp
Tssr46876	Chr5:87677853-87677856 (+)	11,647 bp
Tssr46877	Chr5:87678016-87678060 (+)	11,830 bp
Tssr46878	Chr5:87680015-87680054 (+)	13,827 bp
Tssr46879	Chr5:87680808-87680826 (+)	14,609 bp
Tssr46880	Chr5:87680844-87680869 (+)	14,649 bp
Tssr1527	Chr5:87680890-87680897 (+)	14,686 bp
Tssr46881	Chr5:87682184-87682224 (+)	15,996 bp
Tssr1528	Chr5:87682341-87682342 (+)	16,134 bp
Tssr46882	Chr5:87682541-87682550 (+)	16,338 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/15/2020 MGI 6.15