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Csn1s1 Gene Detail
Summary
  • Symbol
    Csn1s1
  • Name
    casein alpha s1
  • Synonyms
    Csna
  • Feature Type
    protein coding gene
  • IDs
    MGI:88540
    NCBI Gene: 12990
  • Member of
    Csn cluster
  • Gene Overview
    MyGene.info: CSN1S1
Location & Maps
more
  • Sequence Map
    Chr5:87666208-87682578 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      16371 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 43.56 cM
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    CSN1S1, casein alpha s1
  • Human Ortholog
    CSN1S1, casein alpha s1
    Orthology source: HGNC
  • Synonyms
    CASA, CSN1
  • Links
    NCBI Gene ID: 1446
    neXtProt AC: NX_P47710

  • Chr Location
    4q21.1; chr4:69931062-69946570 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    4 involving Csn1s1
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for a null mutation display reduced milk prodution and abnormal milk composition with reduced protein, calcium and phosphate concentrations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    46
  • Tissues
    45
  • cDNA Data
    1899
  • Literature Summary
    2
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054070 VEGA Gene Model | MGI Sequence Detail 16371 C57BL/6J ±  kb
transcript OTTMUST00000134355 VEGA | MGI Sequence Detail 1411 Not Applicable  
polypeptide OTTMUSP00000071256 VEGA | MGI Sequence Detail 313 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    156 from dbSNP Build 142
  • RFLP
    2
Protein
Information
less
Molecular
Reagents
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  • All nucleic 1912
    Genomic 7
    cDNA 1902
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-2198, MGI:2140790, MGI:2141176
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:6738 Gupta P, et al., Localization of the casein gene family to a single mouse chromosome. J Cell Biol. 1982 Apr;93(1):199-204
  • Latest
    J:174932 Kolb AF, et al., Milk Lacking alpha-Casein Leads to Permanent Reduction in Body Size in Mice. PLoS One. 2011;6(7):e21775
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory