Csn1s1 MGI Mouse Gene Detail - MGI:88540

Csn1s1 Gene Detail

Symbol

Csn1s1
Name

casein alpha s1
Synonyms

Csna

Feature Type

protein coding gene
IDs

MGI:88540
NCBI Gene: 12990
Member of

Csn cluster
Gene Overview

MyGene.info: CSN1S1

Sequence Map

Chr5:87666208-87682578 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

16371 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 43.56 cM
Mapping Data

14 experiments

Human Ortholog

CSN1S1, casein alpha s1

Human Ortholog

CSN1S1, casein alpha s1
Orthology source: HGNC
Synonyms

CASA, CSN1
Links

HGNC:2445

NCBI Gene ID: 1446

neXtProt AC: NX_P47710

UniProt: P47710
Chr Location

4q13.3; chr4:69931062-69946570 (+) GRCh38.p7

HCOP

human homology predictions: CSN1S1
Protein SuperFamily

alpha-s1-casein
Gene Tree

Csn1s1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Radiation induced

1
Spontaneous

1
Targeted

1
Genomic Mutations

4 involving Csn1s1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for a null mutation display reduced milk prodution and abnormal milk composition with reduced protein, calcium and phosphate concentrations.

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All GO Annotations

3
GO References

2

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

46
Tissues

45
cDNA Data

1899
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Csn1s1 interacts with 86 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

69
RefSeq

6
UniProt

7
CCDS

CCDS51534.1, CCDS80314.1
UniGene

427467

			Length	Strain/Species	Flank
genomic	OTTMUSG00000054070	VEGA Gene Model \| MGI Sequence Detail	16371	C57BL/6J	± kb
transcript	OTTMUST00000134355	VEGA \| MGI Sequence Detail	1411	Not Applicable
polypeptide	OTTMUSP00000071256	VEGA \| MGI Sequence Detail	313	Not Applicable

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SNPs within 2kb

156 from dbSNP Build 142

RFLP

2

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UniProt

7 Sequences
Protein Ontology

PR:000005940 alpha-S1-casein

(term hierarchy)
InterPro Domains

IPR026999 Alpha-s1 casein

IPR001588 Casein, alpha/beta

IPR031305 Casein alpha/beta, conserved site

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All nucleic 1912

Genomic 7

cDNA 1902

Primer pair 1

Other 2

Microarray probesets 3

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MGD-MRK-2198, MGI:2140790, MGI:2141176

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 7
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:237813 Chen JQ, et al., Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent. PLoS One. 2015;10(6):e0129895

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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