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Csn1s1 Gene Detail
Summary
  • Symbol
    Csn1s1
  • Name
    casein alpha s1
  • Synonyms
    Csna
  • Feature Type
    protein coding gene
  • IDs
    MGI:88540
    NCBI Gene: 12990
  • Member of
    Csn cluster
  • Gene Overview
    MyGene.info: CSN1S1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr5:87666208-87682578 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      16371 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 43.56 cM
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    CSN1S1, casein alpha s1
  • Human Ortholog
    CSN1S1, casein alpha s1
    Orthology source: HGNC
  • Synonyms
    CASA, CSN1
  • Links
    NCBI Gene ID: 1446
    neXtProt AC: NX_P47710
    UniProt: P47710

  • Chr Location
    4q13.3; chr4:69931062-69946570 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display reduced milk prodution and abnormal milk composition with reduced protein, calcium and phosphate concentrations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    46
  • Tissues
    45
  • cDNA Data
    1899
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000054070 VEGA Gene Model | MGI Sequence Detail 16371 C57BL/6J ±  kb
    transcript OTTMUST00000134355 VEGA | MGI Sequence Detail 1411 Not Applicable  
    polypeptide OTTMUSP00000071256 VEGA | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      156 from dbSNP Build 142
    • RFLP
      2
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1912
      Genomic 7
      cDNA 1902
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2198, MGI:2140790, MGI:2141176
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 1
      Phenotypes 7
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:237813 Chen JQ, et al., Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent. PLoS One. 2015;10(6):e0129895
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory