About   Help   FAQ
Csk
Gene Detail
Symbol

Name
ID
Csk
c-src tyrosine kinase
MGI:88537
Feature Type
protein coding gene
Genetic Map
Chromosome 9
31.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr9:57626647-57645653 bp, - strand
From Ensembl annotation of GRCm38

  19007 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55818  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CSK
Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Csk

Human
homologs
CSK, c-src tyrosine kinase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1445
neXtProt AC: NX_P41240

Human Chr (Location): 15q24.1; chr15:74782084-74803198 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(3) Targeted(11) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit growth retardation, neural tube defects, and developmental arrest at the 10-12 somite stage. Mutants die between embryonic days nine and ten.
 
Interactions
Csk interacts with 94 markers (Mir1a-1, Mir1b, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process adaptive immune response, adherens junction organization, ...
Component cell-cell junction, cytoplasm, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (33)    Tissues (16)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 18
Northern blot 3
Western blot 3
RT-PCR 9
cDNA source data(132)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CSK ; Xenbase csk ; ZFIN csk    NEW 
Molecular
reagents
All nucleic(139) Genomic(1) cDNA(134) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000032312 (Evidence)
Entrez Gene 12988 (Evidence)
UniGene 21974
DFCI TC1572858
DoTS DT.101400123, DT.493960
NIA Mouse Gene Index U030926
EC 2.7.10.2
PDB 1JEG
Consensus CDS Project CCDS23228.1
International Mouse Phenotyping Consortium Status Csk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032312 Ensembl Gene Model | MGI Sequence Detail 19007 C57BL/6J ±  kb
transcript ENSMUST00000034863 Ensembl | MGI Sequence Detail 2748 Not Applicable 
polypeptide ENSMUSP00000034863 Ensembl | MGI Sequence Detail 450 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(10) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 SH3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000005938 tyrosine-protein kinase CSK
References
(Earliest) J:3319 Gilardi-Hebenstreit P, et al., An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain [published erratum appears in Oncogene 1993 Apr;8(4):1103]. Oncogene. 1992 Dec;7(12):2499-506
(Latest) J:208674 Tan YX, et al., Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nat Immunol. 2014 Feb;15(2):186-94
All references(88)
Other
accession IDs
MGD-MRK-2195, MGI:2143301

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory