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Cs Gene Detail
Summary
  • Symbol
    Cs
  • Name
    citrate synthase
  • Synonyms
    2610511A05Rik, 9030605P22Rik, ahl4, Cis
  • Feature Type
    protein coding gene
  • IDs
    MGI:88529
    NCBI Gene: 12974
Location & Maps
more
  • Sequence Map
    Chr10:128337832-128362479 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24648 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 76.53 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CS, citrate synthase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CS, citrate synthase
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 1431
    neXtProt AC: NX_O75390

  • Chr Location
    12q13.2; chr12:56271699-56300391 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56073
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: CS
  • Gene Tree
    Cs
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    42
  • Gene trapped
    38
  • QTL
    2
  • Targeted
    2
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12974 NCBI Gene Model | MGI Sequence Detail 24648 C57BL/6J ±  kb
transcript NM_026444 RefSeq | MGI Sequence Detail 2954 C57BL/6  
polypeptide Q9CZU6 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    159 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-1986, MGD-MRK-2184, MGI:1915151, MGI:1918798, MGI:2143907, MGI:3514039
References
more
  • Summaries
    All 48
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:4573 Cox DR, et al., Comparative gene mapping in man and mouse: assignment of the gene for citrate synthase (Cis) to mouse Chromosome 10. Cytogenet Cell Genet. 1982;32:259
  • Latest
    J:218220 Szczesny B, et al., Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function. Nucleic Acids Res. 2014 Dec 1;42(21):13161-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory