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Cryge
Gene Detail
Symbol

Name
ID
Member of
Cryge
crystallin, gamma E
MGI:88525
Cryg cluster
Synonyms
Cryg-6
Feature Type
protein coding gene
Genetic Map
Chromosome 1
32.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr1:65048554-65051149 bp, - strand
From VEGA annotation of GRCm38

  2596 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128417  Vertebrate Homology Class
2 mouse; 1 rat; 1 rhesus macaque; 2 cattle; 2 dog; 2 zebrafish

Protein SuperFamily: beta/gamma crystallins
Gene Tree: Cryge

Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Chemically induced (ENU)(4) Gene trapped(21) Radiation induced(2) Spontaneous(4) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Mutations in this gene produce severe, nuclear and zonular cataracts with microphthalmia.
 
Interactions
Cryge interacts with 38 markers (Mir18, Mir18b, Mir181b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process eye development, lens development in camera-type eye
Function structural constituent of eye lens
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (57)    Tissues (32)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 27
Northern blot 9
RT-PCR 21
cDNA source data(199)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(205) Genomic(2) cDNA(200) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021574 (Evidence)
Ensembl Gene ModelENSMUSG00000070870 (Evidence)
Entrez Gene12968 (Evidence)
UniGene258170
DoTSDT.101720839, DT.94182838
Consensus CDS ProjectCCDS35598.1
International Mouse Knockout Project StatusCryge
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021574 VEGA Gene Model | MGI Sequence Detail 2596 C57BL/6J ±  kb
transcript OTTMUST00000051206 VEGA | MGI Sequence Detail 631 Not Applicable 
polypeptide OTTMUSP00000024043 VEGA | MGI Sequence Detail 174 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(5)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(62 from dbSNP Build 137)    SNPs within 2kb including multiple locations(68)
Protein-related
information
ResourceIDDescription
InterPro IPR001064 Beta/gamma crystallin
InterPro IPR011024 Gamma-crystallin-related
Protein Ontology PR:000006201 gamma-crystallin E
References
(Earliest) J:6481 Oda S, et al., Impaired development of lens fibers in genetic microphthalmia, eye lens obsolescence, Elo, of the mouse. Exp Eye Res. 1980 Dec;31(6):673-81
(Latest) J:178731 Xie Q, et al., The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71
All references(69)
Other
accession IDs
MGD-MRK-2175, MGD-MRK-2180

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory