Cryge
Gene Detail

Symbol Name ID

Cryge crystallin, gamma E MGI:88525

Synonyms

Cryg-6

Feature Type

protein coding gene

Genetic Map

Chromosome 1

32.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr1:65048554-65051149 bp, - strand From VEGA annotation of GRCm38   2596 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:133092  Vertebrate Homology Class
1 mouse; 1 rat; 1 zebrafish

Protein SuperFamily: beta/gamma crystallins
Gene Tree: Cryge

Alleles and phenotypes

All alleles(34) : Targeted(3) Gene trapped(21) Spontaneous(4) Chemically induced(4) Radiation induced(2)
 

Mutations in this gene produce severe, nuclear and zonular cataracts with microphthalmia.

 
Human Diseases Modeled Using Mouse Cryge (1)    Alleles Annotated to Human Diseases(4)   

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process	eye development, lens development in camera-type eye
Function	structural constituent of eye lens

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (57)    Tissues (31)    Images (9)
Theiler Stages: 16, 19, 20, 23, 24, 28

Assay Type	Results
RNA in situ	27
Northern blot	9
RT-PCR	21

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(2) cDNA(11) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021574 (Evidence)
Ensembl Gene Model	ENSMUSG00000070870 (Evidence)
Entrez Gene	12968 (Evidence)
DoTS	DT.101720839, DT.94182838
Consensus CDS Project	CCDS35598.1
International Mouse Knockout Project Status	Cryge

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021574	VEGA Gene Model | MGI Sequence Detail	2596	C57BL/6J
transcript	OTTMUST00000051206	VEGA | MGI Sequence Detail	631	Not Applicable
polypeptide	OTTMUSP00000024043	VEGA | MGI Sequence Detail	174	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(40 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001064	Beta/gamma crystallin
InterPro	IPR011024	Gamma-crystallin-related
Protein Ontology	PR:000006201	gamma-crystallin E

References

(Earliest) J:6481 Oda S, et al., Impaired development of lens fibers in genetic microphthalmia, eye lens obsolescence, Elo, of the mouse. Exp Eye Res. 1980 Dec;31(6):673-81
(Latest) J:178731 Xie Q, et al., The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71
All references(68)

Other accession IDs

MGD-MRK-2175, MGD-MRK-2180