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Crygd Gene Detail
Summary
  • Symbol
    Crygd
  • Name
    crystallin, gamma D
  • Synonyms
    Aey4, Cryg-1, DGcry-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88524
    NCBI Gene: 12967
  • Member of
    Cryg cluster
Location & Maps
more
  • Sequence Map
    Chr1:65061872-65063452 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1581 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 32.80 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    CRYGD, crystallin gamma D
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CRYGD, crystallin gamma D
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CACA, CCA3, CCP, CRYG4, cry-g-D, CTRCT4, PCC
  • Links
    NCBI Gene ID: 1421
    neXtProt AC: NX_P07320

  • Chr Location
    2q33.3; chr2:208121607-208124589 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Crygd mouse models; 1 with human CRYGD associations

Human Disease Mouse Models
       Cataract 4, Multiple Types; CTRCT4   OMIM: 115700 View 2 models
       Cataract 2, Multiple Types; CTRCT2   OMIM: 604307 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 6 alleles in 4 genetic backgrounds
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    2
  • Targeted
    5
  • Genomic Mutations
    2 involving Crygd
Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033410 VEGA Gene Model | MGI Sequence Detail 1581 C57BL/6J ±  kb
transcript OTTMUST00000083888 VEGA | MGI Sequence Detail 613 Not Applicable  
polypeptide OTTMUSP00000045131 VEGA | MGI Sequence Detail 174 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    56 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR001064 Beta/gamma crystallin
    IPR011024 Gamma-crystallin-related
Molecular
Reagents
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  • All nucleic 146
    cDNA 142
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11853, MGD-MRK-2170, MGD-MRK-2179, MGD-MRK-8836, MGI:96805
References
more
  • Summaries
    All 59
    Developmental Gene Expression 22
    Diseases 2
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:6755 Skow LC, Location of a gene controlling electrophoretic variation in mouse gamma-crystallins. Exp Eye Res. 1982 Apr;34(4):509-16
  • Latest
    J:197830 Zhang R, et al., Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse. J Biol Chem. 2013 Apr 12;288(15):10275-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory