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Crygd
Gene Detail
Symbol

Name
ID
Member of
Crygd
crystallin, gamma D
MGI:88524
Cryg cluster
Synonyms
Aey4, Cryg-1, DGcry-1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
32.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr1:65061872-65063452 bp, - strand
From VEGA annotation of GRCm38

  1581 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36213  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

HCOP human homology predictions: CRYGD
Protein SuperFamily: beta/gamma crystallins
Gene Tree: Crygd

Human
homologs
CRYGD, crystallin, gamma D
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1421
neXtProt AC: NX_P07320

Human Synonyms: CACA, CCA3, CCP, CRYG4, cry-g-D, CTRCT4, PCC

Human Chr (Location): 2q33.3; chr2:208121607-208124589 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CRYGD

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(4) Gene trapped(1) Spontaneous(2) Targeted(5)
 
Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.
 
Human Diseases Modeled in Mice Using Crygd (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)
Interactions
Crygd interacts with 2 markers (Mir181b-1, Mir222)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cellular response to reactive oxygen species, eye development, ...
Component cytoplasm, nucleus
Function structural constituent of eye lens
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (186)    Tissues (35)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 160
Northern blot 15
RT-PCR 11
cDNA source data(140)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(146) cDNA(142) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000033410 (Evidence)
Ensembl Gene Model ENSMUSG00000067299 (Evidence)
Entrez Gene 12967 (Evidence)
UniGene 425031
DoTS DT.99863392
NIA Mouse Gene Index U021412
Consensus CDS Project CCDS35599.1
International Mouse Phenotyping Consortium Status Crygd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033410 VEGA Gene Model | MGI Sequence Detail 1581 C57BL/6J ±  kb
transcript OTTMUST00000083888 VEGA | MGI Sequence Detail 613 Not Applicable 
polypeptide OTTMUSP00000045131 VEGA | MGI Sequence Detail 174 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(5) : SNPs within 2kb(59 from dbSNP Build 137)    SNPs within 2kb including multiple locations(63)
Protein-related
information
ResourceIDDescription
InterPro IPR001064 Beta/gamma crystallin
InterPro IPR011024 Gamma-crystallin-related
Protein Ontology PR:000005917 gamma-crystallin D
References
(Earliest) J:6755 Skow LC, Location of a gene controlling electrophoretic variation in mouse gamma-crystallins. Exp Eye Res. 1982 Apr;34(4):509-16
(Latest) J:197830 Zhang R, et al., Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse. J Biol Chem. 2013 Apr 12;288(15):10275-85
All references(61)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11853, MGD-MRK-2170, MGD-MRK-2179, MGD-MRK-8836, MGI:96805

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory