Crygd
Gene Detail

Symbol Name ID

Crygd crystallin, gamma D MGI:88524

Synonyms

Aey4, Cryg-1, DGcry-1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

32.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr1:65061872-65063452 bp, - strand From VEGA annotation of GRCm38   1581 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36213  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: beta/gamma crystallins
Gene Tree: Crygd

Human homologs

Human Homolog		CRYGD, crystallin, gamma D
NCBI Gene ID		1421
neXtProt AC		NX_P07320
Human Synonyms		CACA, CCA3, CCP, CRYG4, cry-g-D
Human Chr (Location)		2q33.3; chr2:208986331-208989313 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CRYGD

Alleles and phenotypes

All alleles(11) : Targeted(4) Gene trapped(1) Spontaneous(2) Chemically induced(4)
 

Heterozygotes for a spontaneous mutation exhibit a dense nuclear cataract and mild microphthalmia by 2-months of age, followed by posterior capsular rupture into the posterior vitreous by 3-months. In homozygotes, the microphthalmia is more pronounced.

 
Human Diseases Modeled Using Mouse Crygd (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	cellular response to reactive oxygen species, eye development, ...
Component	cytoplasm, nucleus
Function	structural constituent of eye lens

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (186)    Tissues (34)    Images (23)
Theiler Stages: 16, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	160
Northern blot	15
RT-PCR	11

cDNA source data(140)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(146) cDNA(142) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000033410 (Evidence)
Ensembl Gene Model	ENSMUSG00000067299 (Evidence)
Entrez Gene	12967 (Evidence)
UniGene	425031
DoTS	DT.99863392
NIA Mouse Gene Index	U021412
Consensus CDS Project	CCDS35599.1
International Mouse Knockout Project Status	Crygd

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033410	VEGA Gene Model | MGI Sequence Detail	1581	C57BL/6J
transcript	OTTMUST00000083888	VEGA | MGI Sequence Detail	613	Not Applicable
polypeptide	OTTMUSP00000045131	VEGA | MGI Sequence Detail	174	Not Applicable

All sequences(28) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(5) : SNPs(29 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001064	Beta/gamma crystallin
InterPro	IPR011024	Gamma-crystallin-related
Protein Ontology	PR:000005917	gamma-crystallin D

References

(Earliest) J:6755 Skow LC, Location of a gene controlling electrophoretic variation in mouse gamma-crystallins. Exp Eye Res. 1982 Apr;34(4):509-16
(Latest) J:178731 Xie Q, et al., The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71
All references(64)

Other accession IDs

MGD-MRK-11853, MGD-MRK-2170, MGD-MRK-2179, MGD-MRK-8836, MGI:96805