Crygc
Gene Detail

Symbol Name ID

Crygc crystallin, gamma C MGI:88523

Synonyms

Cryg-5

Feature Type

protein coding gene

Genetic Map

Chromosome 1

32.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:65071525-65073689 bp, - strand From VEGA annotation of GRCm38   2165 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36281  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: beta/gamma crystallins
Gene Tree: Crygc

Human homologs

Human Homolog		CRYGC, crystallin, gamma C
NCBI Gene ID		1420
neXtProt AC		NX_P07315
Human Synonyms		CCL, CRYG3
Human Chr (Location)		2q33.3; chr2:208992861-208994554 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CRYGC

Alleles and phenotypes

All alleles(7) : Targeted(1) Gene trapped(3) Spontaneous(1) Chemically induced(2)
 

Homozygotes and heterozygotes for a chlorambucil-induced mutation exhibit a nuclear and radial cataract characterized by persistence of the lens fiber cell nuclei. Homozygotes present a more severe cataract with mild microphthalmia.

 
Human Diseases Modeled Using Mouse Crygc (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	camera-type eye development, eye development, ...
Component	cytoplasm, nucleus
Function	structural constituent of eye lens

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (38)    Tissues (7)   
Theiler Stages: 20, 21, 22, 23, 24, 28

Assay Type	Results
Northern blot	9
RT-PCR	29

cDNA source data(82)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(86) Genomic(1) cDNA(82) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021759 (Evidence)
Ensembl Gene Model	ENSMUSG00000025952 (Evidence)
Entrez Gene	12966 (Evidence)
UniGene	485021
DFCI	TC1576698
DoTS	DT.101380996
NIA Mouse Gene Index	U353666
PDB	2V2U
Consensus CDS Project	CCDS15012.1, CCDS35600.1
International Mouse Knockout Project Status	Crygc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021759	VEGA Gene Model | MGI Sequence Detail	2165	C57BL/6J
transcript	OTTMUST00000051647	VEGA | MGI Sequence Detail	783	Not Applicable
polypeptide	OTTMUSP00000024347	VEGA | MGI Sequence Detail	174	Not Applicable

All sequences(27) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001064	Beta/gamma crystallin
InterPro	IPR011024	Gamma-crystallin-related
Protein Ontology	PR:000005916	gamma-crystallin C

References

(Earliest) J:9014 Quinlan P, et al., The mouse eye lens obsolescence (Elo) mutant: studies on crystallin gene expression and linkage analysis between the mutant locus and the gamma-crystallin genes. Genes Dev. 1987 Sep;1(7):637-44
(Latest) J:178731 Xie Q, et al., The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71
All references(46)

Other accession IDs

MGD-MRK-2174, MGD-MRK-2178