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Crygc Gene Detail
Summary
  • Symbol
    Crygc
  • Name
    crystallin, gamma C
  • Synonyms
    Cryg-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88523
    NCBI Gene: 12966
  • Member of
    Cryg cluster
  • Gene Overview
    MyGene.info: CRYGC
Location & Maps
more
  • Sequence Map
    Chr1:65071525-65073689 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2165 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CRYGC, crystallin gamma C
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CRYGC, crystallin gamma C
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CCL, CRYG3, CTRCT2
  • Links
    NCBI Gene ID: 1420
    neXtProt AC: NX_P07315

  • Chr Location
    2q33.3; chr2:208128137-208139738 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Crygc mouse models; 1 with human CRYGC associations

Human Disease Mouse Models
       Cataract 2, Multiple Types; CTRCT2   OMIM: 604307 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    4 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    3
  • Gene trapped
    3
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Transgenic
    1
  • Genomic Mutations
    2 involving Crygc
Homozygotes and heterozygotes for a chlorambucil-induced mutation exhibit a nuclear and radial cataract characterized by persistence of the lens fiber cell nuclei. Homozygotes present a more severe cataract with mild microphthalmia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021759 VEGA Gene Model | MGI Sequence Detail 2165 C57BL/6J ±  kb
transcript OTTMUST00000122785 VEGA | MGI Sequence Detail 612 Not Applicable  
polypeptide OTTMUSP00000067245 VEGA | MGI Sequence Detail 175 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    34 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 86
    Genomic 1
    cDNA 82
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-2174, MGD-MRK-2178
References
more
  • Summaries
    All 43
    Developmental Gene Expression 15
    Diseases 2
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:9014 Quinlan P, et al., The mouse eye lens obsolescence (Elo) mutant: studies on crystallin gene expression and linkage analysis between the mutant locus and the gamma-crystallin genes. Genes Dev. 1987 Sep;1(7):637-44
  • Latest
    J:204144 Wu Y, et al., Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9. Cell Stem Cell. 2013 Dec 5;13(6):659-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory