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Crygc
Gene Detail
 Symbol
Name
ID
Member of
Crygc
crystallin, gamma C
MGI:88523
Cryg cluster
Synonyms Cryg-5
Feature Type protein coding gene
Genetic Map
Chromosome 1
32.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:65071525-65073689 bp, - strand
From VEGA annotation of GRCm38

  2165 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36281  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 zebrafish

Protein SuperFamily: beta/gamma crystallins
Gene Tree: Crygc

Human
homologs
Human Homolog CRYGC, crystallin, gamma C
NCBI Gene ID 1420
neXtProt AC  NX_P07315
Human Synonyms  CCL, CRYG3, CTRCT2
Human Chr (Location)  2q33.3; chr2:208128137-208129830 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CRYGC
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (other)(2) Gene trapped(3) Spontaneous(1) Targeted(1)
 
Homozygotes and heterozygotes for a chlorambucil-induced mutation exhibit a nuclear and radial cataract characterized by persistence of the lens fiber cell nuclei. Homozygotes present a more severe cataract with mild microphthalmia.
 
Human Diseases Modeled Using Mouse Crygc (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Interactions
Crygc interacts with 14 markers (Mir23b, Mir152, Mir154, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process camera-type eye development, eye development, ...
Component cytoplasm, nucleus
Function structural constituent of eye lens
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (38)    Tissues (7)   
Theiler Stages: 20, 21, 22, 23, 24, 28
Assay TypeResults
Northern blot 9
RT-PCR 29
cDNA source data(82)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(86) Genomic(1) cDNA(82) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021759 (Evidence)
Ensembl Gene ModelENSMUSG00000025952 (Evidence)
Entrez Gene12966 (Evidence)
UniGene491115
DFCITC1576698
DoTSDT.101380996
NIA Mouse Gene IndexU353666
PDB2V2U
Consensus CDS ProjectCCDS15012.1, CCDS35600.1
International Mouse Knockout Project StatusCrygc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021759 VEGA Gene Model | MGI Sequence Detail 2165 C57BL/6J ±  kb
transcript OTTMUST00000122785 VEGA | MGI Sequence Detail 612 Not Applicable 
polypeptide OTTMUSP00000067245 VEGA | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(37 from dbSNP Build 137)    SNPs within 2kb including multiple locations(41)
Protein-related
information
ResourceIDDescription
InterPro IPR001064 Beta/gamma crystallin
InterPro IPR011024 Gamma-crystallin-related
Protein Ontology PR:000005916 gamma-crystallin C
References (Earliest) J:9014 Quinlan P, et al., The mouse eye lens obsolescence (Elo) mutant: studies on crystallin gene expression and linkage analysis between the mutant locus and the gamma-crystallin genes. Genes Dev. 1987 Sep;1(7):637-44
(Latest) J:204144 Wu Y, et al., Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9. Cell Stem Cell. 2013 Dec 5;13(6):659-62
All references(48)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-2174, MGD-MRK-2178

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory