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Cr1l Gene Detail
Summary
  • Symbol
    Cr1l
  • Name
    complement component (3b/4b) receptor 1-like
  • Synonyms
    Crry, mCRY
  • Feature Type
    protein coding gene
  • IDs
    MGI:88513
    NCBI Gene: 12946
Location & Maps
more
  • Sequence Map
    Chr1:195097382-195131586 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34205 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 98.43 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    CR1L, complement component 3b/4b receptor 1-like
  • Vertebrate Orthologs
    4
  • Human Ortholog
    CR1L, complement component 3b/4b receptor 1-like
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 1379
    neXtProt AC: NX_Q2VPA4

  • Chr Location
    1q32.1; chr1:207645113-207723691 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    2
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a knock-out allele die by E16.5 with abnormal C3 deposition. Mice homozygous for a null allele activated in single positive thymocytes exhibit T cell lymphopenia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050896 VEGA Gene Model | MGI Sequence Detail 34205 C57BL/6J ±  kb
transcript OTTMUST00000128984 VEGA | MGI Sequence Detail 1651 Not Applicable  
polypeptide OTTMUSP00000069344 VEGA | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    115 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000006200 complement regulatory protein Crry
  • PDB
  • InterPro Domains
    IPR011759 Cytochrome C oxidase subunit II, transmembrane domain
    IPR000436 Sushi/SCR/CCP domain
Molecular
Reagents
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  • All nucleic 135
    Genomic 10
    cDNA 123
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12142, MGD-MRK-2158
References
more
  • Summaries
    All 74
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 38
  • Earliest
    J:8686 Aegerter-Shaw M, et al., Expansion of the complement receptor gene family. Identification in the mouse of two new genes related to the CR1 and CR2 gene family. J Immunol. 1987 May 15;138(10):3488-94
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory