About   Help   FAQ
Cr1l
Gene Detail
 Symbol
Name
ID
Cr1l
complement component (3b/4b) receptor 1-like
MGI:88513
Synonyms Crry, mCRY
Feature Type protein coding gene
Genetic Map
Chromosome 1
98.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr1:195103789-195131570 bp, - strand
From Ensembl annotation of GRCm38

  27782 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128275  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee

Gene Tree: Cr1l

Human
homologs
Human Homolog CR1L, complement component (3b/4b) receptor 1-like
NCBI Gene ID 1379
neXtProt AC  NX_Q2VPA4
Human Chr (Location)  1q32.1; chr1:207645113-207723691 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele die by E16.5 with abnormal C3 deposition. Mice homozygous for a null allele activated in single positive thymocytes exhibit T cell lymphopenia.
 
Interactions
Cr1l interacts with 23 markers (Mir7-1, Mir26b, Mir146, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process complement activation, classical pathway, female pregnancy, ...
Component external side of plasma membrane, integral component of membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (142)    Tissues (92)    Images (26)
Theiler Stages: 16, 18, 20, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 54
RT-PCR 88
cDNA source data(115)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(135) Genomic(10) cDNA(123) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000016481 (Evidence)
Entrez Gene12946 (Evidence)
UniGene301652
DFCITC1577139, TC1600063, TC1602655
DoTSDT.101253249, DT.110894830, DT.55164627, DT.55173740, DT.91439597, DT.91439598, DT.99868103
NIA Mouse Gene IndexU022232, U046824
PDB1NTL
Consensus CDS ProjectCCDS15641.1
International Mouse Knockout Project StatusCr1l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000016481 Ensembl Gene Model | MGI Sequence Detail 27782 C57BL/6J ±  kb
transcript ENSMUST00000075451 Ensembl | MGI Sequence Detail 1661 Not Applicable 
polypeptide ENSMUSP00000074902 Ensembl | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(2)
Polymorphisms RFLP(3) : SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000006200 complement regulatory protein Crry
References (Earliest) J:8686 Aegerter-Shaw M, et al., Expansion of the complement receptor gene family. Identification in the mouse of two new genes related to the CR1 and CR2 gene family. J Immunol. 1987 May 15;138(10):3488-94
(Latest) J:197576 Killick R, et al., Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH. Neurosci Lett. 2013 Jan 15;533:96-9
All references(74)
Other
accession IDs
MGD-MRK-12142, MGD-MRK-2158

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory