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Cr1l Gene Detail
Summary
  • Symbol
    Cr1l
  • Name
    complement component (3b/4b) receptor 1-like
  • Synonyms
    Crry, mCRY
  • Feature Type
    protein coding gene
  • IDs
    MGI:88513
    NCBI Gene: 12946
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:195098747-195131590 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 98.43 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88513
protein coding gene Chr1:195097382-195131590 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016968
protein coding gene Chr1:202273220-202314745 (-)
A/J MGP_AJ_G0016947
protein coding gene Chr1:193968833-194003986 (-)
AKR/J MGP_AKRJ_G0016912
protein coding gene Chr1:199709074-199745514 (-)
BALB/cJ MGP_BALBcJ_G0016905
protein coding gene Chr1:194669533-194703388 (-)
C3H/HeJ MGP_C3HHeJ_G0016729
protein coding gene Chr1:200601373-200637007 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017368
protein coding gene Chr1:208650604-208685623 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015075
protein coding gene Chr1:185362155-185396325 (-)
CAST/EiJ MGP_CASTEiJ_G0016312
protein coding gene Chr1:200157944-200196476 (-)
CBA/J MGP_CBAJ_G0016703
protein coding gene Chr1:216346846-216380772 (-)
DBA/2J MGP_DBA2J_G0016809
protein coding gene Chr1:192690161-192723752 (-)
FVB/NJ MGP_FVBNJ_G0016805
protein coding gene Chr1:190782506-190816850 (-)
LP/J MGP_LPJ_G0016884
protein coding gene Chr1:203406640-203444830 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016837
protein coding gene Chr1:222998746-223042221 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017405
protein coding gene Chr1:199552969-199588388 (-)
PWK/PhJ MGP_PWKPhJ_G0016099
protein coding gene Chr1:191998156-192032759 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015875
protein coding gene Chr1:198599907-198637785 (-)
WSB/EiJ MGP_WSBEiJ_G0016374
protein coding gene Chr1:199836621-199873402 (-)



Homology
more
  • Human Ortholog
    CR1L, complement C3b/C4b receptor 1 like
  • Vertebrate Orthologs
    4
  • Human Ortholog
    CR1L, complement C3b/C4b receptor 1 like
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 1379
    neXtProt AC: NX_Q2VPA4
    UniProt: Q2VPA4

  • Chr Location
    1q32.2; chr1:207645113-207723691 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die by E16.5 with abnormal C3 deposition. Mice homozygous for a null allele activated in single positive thymocytes exhibit T cell lymphopenia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12946 NCBI Gene Model | MGI Sequence Detail 32844 C57BL/6J ±  kb
    transcript NM_001355061 RefSeq | MGI Sequence Detail 1696 C57BL/6  
    polypeptide Q64735 UniProt | EBI | MGI Sequence Detail 483 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 136
      Genomic 10
      cDNA 124
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12142, MGD-MRK-2158
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 41
    • Earliest
      J:8686 Aegerter-Shaw M, et al., Expansion of the complement receptor gene family. Identification in the mouse of two new genes related to the CR1 and CR2 gene family. J Immunol. 1987 May 15;138(10):3488-94
    • Latest
      J:242022 Lenis TL, et al., Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3987-3992

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    07/09/2019
    MGI 6.14
    The Jackson Laboratory