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Crp Gene Detail
Summary
  • Symbol
    Crp
  • Name
    C-reactive protein, pentraxin-related
  • Feature Type
    protein coding gene
  • IDs
    MGI:88512
    NCBI Gene: 12944
  • Gene Overview
    MyGene.info: CRP
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:172525623-172527533 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 80.13 cM
  • Mapping Data
    21 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    19 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88512
protein coding gene Chr1:172525622-172660598 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016796
protein coding gene Chr1:178580548-178709171 (+)
A/J MGP_AJ_G0016775
protein coding gene Chr1:171283694-171409695 (+)
AKR/J MGP_AKRJ_G0016741
protein coding gene Chr1:176444800-176587753 (+)
BALB/cJ MGP_BALBcJ_G0016736
protein coding gene Chr1:171812837-171949194 (+)
C3H/HeJ MGP_C3HHeJ_G0016560
protein coding gene Chr1:177021906-177162309 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017198
protein coding gene Chr1:184503508-184648850 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014904
protein coding gene Chr1:162970773-163091722 (+)
CAST/EiJ MGP_CASTEiJ_G0016140
protein coding gene Chr1:176388315-176523062 (+)
CBA/J MGP_CBAJ_G0016534
protein coding gene Chr1:191075957-191230022 (+)
DBA/2J MGP_DBA2J_G0016641
protein coding gene Chr1:170203788-170333747 (+)
FVB/NJ MGP_FVBNJ_G0016638
protein coding gene Chr1:168459799-168578357 (+)
LP/J MGP_LPJ_G0016712
protein coding gene Chr1:179654166-179783126 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016665
protein coding gene Chr1:198291351-198432181 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017234
protein coding gene Chr1:176326480-176484866 (+)
PWK/PhJ MGP_PWKPhJ_G0015926
protein coding gene Chr1:169588699-169720531 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015708
protein coding gene Chr1:175286523-175423466 (+)
WSB/EiJ MGP_WSBEiJ_G0016202
protein coding gene Chr1:176479767-176608749 (+)



Homology
more
  • Human Ortholog
    CRP, C-reactive protein
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRP, C-reactive protein
  • Synonyms
    PTX1
  • Links
    NCBI Gene ID: 1401
    neXtProt AC: NX_P02741
    UniProt: P02741

  • Chr Location
    1q23.2; chr1:159712289-159714623 (-)  GRCh38.p7

  • Alliance of Genome Resources
    Crp stringent orthology
    1 human;1 mouse;1 rat;5 zebrafish
  • HCOP
    vertebrate homology predictions: CRP
  • Gene Tree
    Crp
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele lack detectable C-reactive protein in the serum but are otherwise healthy and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12944 NCBI Gene Model | MGI Sequence Detail 1911 C57BL/6J ±  kb
    transcript NM_007768 RefSeq | MGI Sequence Detail 1698 Not Specified  
    polypeptide P14847 UniProt | EBI | MGI Sequence Detail 225 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 21
      cDNA 34
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2156, MGI:2138184
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:129706 Ciliberto G, et al., Inducible and tissue-specific expression of human C-reactive protein in transgenic mice. EMBO J. 1987 Dec 20;6(13):4017-22
    • Latest
      J:309784 Shen ZY, et al., C-Reactive Protein Suppresses the Th17 Response Indirectly by Attenuating the Antigen Presentation Ability of Monocyte Derived Dendritic Cells in Experimental Autoimmune Encephalomyelitis. Front Immunol. 2021;12:589200

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/12/2021
    MGI 6.17
    The Jackson Laboratory