About   Help   FAQ
Crp
Gene Detail
Symbol

Name
ID
Crp
C-reactive protein, pentraxin-related
MGI:88512
STS
Feature Type
protein coding gene
Genetic Map
Chromosome 1
80.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr1:172698055-172833031 bp, + strand
From VEGA annotation of GRCm38

  134977 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128039  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 21 western clawed frog

HCOP human homology predictions: CRP
Protein SuperFamily: C-reactive protein
Gene Tree: Crp

Human
homologs
CRP, C-reactive protein, pentraxin-related
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1401
neXtProt AC: NX_P02741

Human Synonyms: PTX1

Human Chr (Location): 1q23.2; chr1:159712289-159714609 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele lack detectable C-reactive protein in the serum but are otherwise healthy and fertile.
 
Interactions
Crp interacts with 129 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process acute-phase response, cellular response to calcium ion, ...
Component extracellular exosome, extracellular region, ...
Function calcium ion binding, cholesterol binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase crp.2, crp.3, crp.4, LOC100494488    NEW 
Molecular
reagents
All nucleic(57) Genomic(21) cDNA(32) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000050157 (Evidence)
Ensembl Gene Model ENSMUSG00000037942 (Evidence)
Entrez Gene 12944 (Evidence)
UniGene 28767
DFCI TC1583872, TC1739231
DoTS DT.530634, DT.94229803, DT.99747698
NIA Mouse Gene Index U041308
Consensus CDS Project CCDS35787.1
International Mouse Phenotyping Consortium Status Crp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050157 VEGA Gene Model | MGI Sequence Detail 134977 C57BL/6J ±  kb
transcript OTTMUST00000127512 VEGA | MGI Sequence Detail 1695 Not Applicable 
polypeptide OTTMUSP00000068770 VEGA | MGI Sequence Detail 225 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(8) : PCR(6) RFLP(2) SNPs within 2kb(1536 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1538)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001759 Pentaxin
Protein Ontology PR:000005897 C-reactive protein
References
(Earliest) J:53829 Ohnishi S, et al., Structure of the mouse C-reactive protein gene. Biochem Biophys Res Commun. 1988 Oct 31;156(2):814-22
(Latest) J:212127 Simons JP, et al., C-reactive protein is essential for innate resistance to pneumococcal infection. Immunology. 2014 Jul;142(3):414-20
All references(59)
Other
accession IDs
MGD-MRK-2156, MGI:2138184

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory