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Crp
Gene Detail
 Symbol
Name
ID
Crp
C-reactive protein, pentraxin-related
MGI:88512
STS D1Nds9
Feature Type protein coding gene
Genetic Map
Chromosome 1
80.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr1:172698056-172699966 bp, + strand
From NCBI annotation of GRCm38

  1911 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128039  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: C-reactive protein
Gene Tree: Crp

Human
homologs
Human Homolog CRP, C-reactive protein, pentraxin-related
NCBI Gene ID 1401
neXtProt AC  NX_P02741
Human Synonyms  PTX1
Human Chr (Location)  1q23.2; chr1:159712289-159714589 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele lack detectable C-reactive protein in the serum but are otherwise healthy and fertile.
 
Interactions
Crp interacts with 129 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process acute-phase response, cellular response to calcium ion, ...
Component extracellular region, extracellular space, ...
Function calcium ion binding, cholesterol binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (3)    Tissues (3)   
Theiler Stages: 18, 22, 28
Assay TypeResults
RNA in situ 3
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) Genomic(21) cDNA(32) Primer pair(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000037942 (Evidence)
Entrez Gene12944 (Evidence)
UniGene28767
DFCITC1583872, TC1739231
DoTSDT.530634, DT.94229803, DT.99747698
NIA Mouse Gene IndexU041308
Consensus CDS ProjectCCDS35787.1
International Mouse Knockout Project StatusCrp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12944 NCBI Gene Model | MGI Sequence Detail 1911 C57BL/6J ±  kb
transcript NM_007768 RefSeq | MGI Sequence Detail 1698 Not Specified 
polypeptide P14847 UniProt | EBI | MGI Sequence Detail 225 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(8) : PCR(6) RFLP(2) SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001759 Pentaxin
Protein Ontology PR:000005897 C-reactive protein
Graphical View of Protein Domain Structure
References (Earliest) J:53829 Ohnishi S, et al., Structure of the mouse C-reactive protein gene. Biochem Biophys Res Commun. 1988 Oct 31;156(2):814-22
(Latest) J:203691 Denard J, et al., C-reactive protein (CRP) is essential for efficient systemic transduction of recombinant adeno-associated virus vector 1 (rAAV-1) and rAAV-6 in mice. J Virol. 2013 Oct;87(19):10784-91
All references(59)
Other
accession IDs
MGD-MRK-2156, MGI:2138184

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory