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Crp Gene Detail
Summary
  • Symbol
    Crp
  • Name
    C-reactive protein, pentraxin-related
  • Feature Type
    protein coding gene
  • IDs
    MGI:88512
    NCBI Gene: 12944
Location & Maps
more
  • Sequence Map
    Chr1:172698055-172833031 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      134977 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CRP, C-reactive protein, pentraxin-related
  • Vertebrate Orthologs
    29
  • Human Ortholog
    CRP, C-reactive protein, pentraxin-related
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PTX1
  • Links
    NCBI Gene ID: 1401
    neXtProt AC: NX_P02741

  • Chr Location
    1q23.2; chr1:159712289-159714609 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Crp
  • Incidental Mutations
Mice homozygous for a knock-out allele lack detectable C-reactive protein in the serum but are otherwise healthy and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050157 VEGA Gene Model | MGI Sequence Detail 134977 C57BL/6J ±  kb
transcript OTTMUST00000127512 VEGA | MGI Sequence Detail 1695 Not Applicable  
polypeptide OTTMUSP00000068770 VEGA | MGI Sequence Detail 225 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1536 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005897 C-reactive protein
  • InterPro Domains
    IPR013320 Concanavalin A-like lectin/glucanase domain
    IPR030476 Pentaxin, conserved site
    IPR001759 Pentaxin-related
Molecular
Reagents
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  • All nucleic 57
    Genomic 21
    cDNA 32
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-2156, MGI:2138184
References
more
  • Summaries
    All 56
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:53829 Ohnishi S, et al., Structure of the mouse C-reactive protein gene. Biochem Biophys Res Commun. 1988 Oct 31;156(2):814-22
  • Latest
    J:212127 Simons JP, et al., C-reactive protein is essential for innate resistance to pneumococcal infection. Immunology. 2014 Jul;142(3):414-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory