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Crhbp
Gene Detail
 Symbol
Name
ID
Crhbp
corticotropin releasing hormone binding protein
MGI:88497
Synonyms CRH-BP
Feature Type protein coding gene
Genetic Map
Chromosome 13
49.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:95431376-95444831 bp, - strand
From NCBI annotation of GRCm38

  13456 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1418  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: corticotropin-releasing factor binding protein
Gene Tree: Crhbp

Human
homologs
Human Homolog CRHBP, corticotropin releasing hormone binding protein
NCBI Gene ID 1393
neXtProt AC  NX_P24387
Human Synonyms  CRFBP, CRF-BP
Human Chr (Location)  5q11.2-q13.3; chr5:76952855-76969474 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display behavior indicative of increased anxiety. Male mice also show reduced food intake resulting in reduced growth between ages 7 and 15 weeks.
 
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process behavioral response to ethanol, cellular response to calcium ion, ...
Component axon terminus, dendrite, ...
Function corticotropin-releasing hormone binding, peptide binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (21)    Tissues (14)    Images (14)
Theiler Stages: 20, 22, 24, 25, 26, 28
Assay TypeResults
RNA in situ 21
cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021680 (Evidence)
Entrez Gene12919 (Evidence)
UniGene316614
DFCITC1584228
DoTSDT.101341521, DT.110962048, DT.55206719
NIA Mouse Gene IndexU035053
Consensus CDS ProjectCCDS26698.1
International Mouse Knockout Project StatusCrhbp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12919 NCBI Gene Model | MGI Sequence Detail 13456 C57BL/6J ±  kb
transcript NM_198408 RefSeq | MGI Sequence Detail 1697 C57BL/6 
polypeptide Q60571 UniProt | EBI | MGI Sequence Detail 322 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(223 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008435 Corticotropin-releasing factor binding
InterPro IPR000859 CUB domain
Protein Ontology PR:000005868 corticotropin-releasing factor-binding protein
Graphical View of Protein Domain Structure
References (Earliest) J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)
Other
accession IDs
MGD-MRK-2140

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory