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Crhbp Gene Detail
Summary
  • Symbol
    Crhbp
  • Name
    corticotropin releasing hormone binding protein
  • Synonyms
    CRH-BP
  • Feature Type
    protein coding gene
  • IDs
    MGI:88497
    NCBI Gene: 12919
  • Gene Overview
    MyGene.info: CRHBP
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:95431376-95444831 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 49.50 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    215 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88497
protein coding gene Chr13:95431371-95444924 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020840
protein coding gene Chr13:96894668-96911086 (-)
A/J MGP_AJ_G0020794
protein coding gene Chr13:93261030-93279961 (-)
AKR/J MGP_AKRJ_G0020768
protein coding gene Chr13:96111797-96126826 (-)
BALB/cJ MGP_BALBcJ_G0020791
protein coding gene Chr13:93942947-93957272 (-)
C3H/HeJ MGP_C3HHeJ_G0020584
protein coding gene Chr13:95808174-95823408 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021227
protein coding gene Chr13:99839386-99855531 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018796
protein coding gene Chr13:89096492-89109886 (-)
CAST/EiJ MGP_CASTEiJ_G0020103
protein coding gene Chr13:95106120-95119287 (-)
CBA/J MGP_CBAJ_G0020543
protein coding gene Chr13:103795333-103808146 (-)
DBA/2J MGP_DBA2J_G0020668
protein coding gene Chr13:93046363-93060036 (-)
FVB/NJ MGP_FVBNJ_G0020649
protein coding gene Chr13:91831818-91844892 (-)
LP/J MGP_LPJ_G0020743
protein coding gene Chr13:97014307-97027405 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020677
protein coding gene Chr13:104245190-104260498 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021267
protein coding gene Chr13:95512762-95527807 (-)
PWK/PhJ MGP_PWKPhJ_G0019855
protein coding gene Chr13:91814960-91828255 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019679
protein coding gene Chr13:91801115-91814121 (-)
WSB/EiJ MGP_WSBEiJ_G0020160
protein coding gene Chr13:96015691-96030109 (-)



Homology
more
  • Human Ortholog
    CRHBP, corticotropin releasing hormone binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRHBP, corticotropin releasing hormone binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRFBP, CRF-BP
  • Links
    NCBI Gene ID: 1393
    neXtProt AC: NX_P24387
    UniProt: P24387

  • Chr Location
    5q13.3; chr5:76952713-76981143 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display behavior indicative of increased anxiety. Male mice also show reduced food intake resulting in reduced growth between ages 7 and 15 weeks.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12919 NCBI Gene Model | MGI Sequence Detail 13456 C57BL/6J ±  kb
transcript NM_198408 RefSeq | MGI Sequence Detail 1697 C57BL/6  
polypeptide Q60571 UniProt | EBI | MGI Sequence Detail 322 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000005868 corticotropin-releasing factor-binding protein
  • InterPro Domains
    IPR008435 Corticotropin-releasing factor-binding protein
    IPR035914 Spermadhesin, CUB domain superfamily
Molecular
Reagents
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  • All nucleic 20
    cDNA 19
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-2140
References
more
  • Summaries
    All 40
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 5
  • Earliest
    J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
  • Latest
    J:245600 Xie Y, et al., Lef1-dependent hypothalamic neurogenesis inhibits anxiety. PLoS Biol. 2017 Aug;15(8):e2002257

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory