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Crhbp Gene Detail
Summary
  • Symbol
    Crhbp
  • Name
    corticotropin releasing hormone binding protein
  • Synonyms
    CRH-BP
  • Feature Type
    protein coding gene
  • IDs
    MGI:88497
    NCBI Gene: 12919
  • Gene Overview
    MyGene.info: CRHBP
Location & Maps
more
  • Sequence Map
    Chr13:95431376-95444831 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13456 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 49.50 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CRHBP, corticotropin releasing hormone binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRHBP, corticotropin releasing hormone binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRFBP, CRF-BP
  • Links
    NCBI Gene ID: 1393
    neXtProt AC: NX_P24387

  • Chr Location
    5q13.3; chr5:76952835-76981147 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display behavior indicative of increased anxiety. Male mice also show reduced food intake resulting in reduced growth between ages 7 and 15 weeks.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12919 NCBI Gene Model | MGI Sequence Detail 13456 C57BL/6J ±  kb
transcript NM_198408 RefSeq | MGI Sequence Detail 1697 C57BL/6  
polypeptide Q60571 UniProt | EBI | MGI Sequence Detail 322 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    215 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005868 corticotropin-releasing factor-binding protein
  • InterPro Domains
    IPR008435 Corticotropin-releasing factor-binding protein
    IPR000859 CUB domain
Molecular
Reagents
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  • All nucleic 18
    cDNA 18

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-2140
References
more
  • Summaries
    All 35
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 5
  • Earliest
    J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
  • Latest
    J:228853 Hoffmann AD, et al., Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation. PLoS Genet. 2014 Oct;10(10):e1004604

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory