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Masp1
Gene Detail
 Symbol
Name
ID
Masp1
mannan-binding lectin serine peptidase 1
MGI:88492
Synonyms Crarf
Feature Type protein coding gene
Genetic Map
Chromosome 16
14.23 cM, cytoband B2-B3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr16:23451785-23520590 bp, - strand
From NCBI annotation of GRCm38

  68806 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88793  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee

Protein SuperFamily: C1r-like complement-activating serine protease
Gene Tree: Masp1

Alleles
and
phenotypes
All alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knockout allele display decreased survivor rate, reduced body weight, and impaired activation of the lectin and alternative complement pathways.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process complement activation, complement activation, lectin pathway, ...
Component extracellular region, extracellular space
Function calcium-dependent protein binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (16)    Tissues (12)   
Theiler Stages: 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RT-PCR 16
cDNA source data(48)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(54) cDNA(50) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022887 (Evidence)
Entrez Gene17174 (Evidence)
UniGene1213
DFCITC1579229, TC1618198
DoTSDT.40178722, DT.97356042
NIA Mouse Gene IndexU036924
EC3.4.21.-
Consensus CDS ProjectCCDS37303.1
International Mouse Knockout Project StatusMasp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17174 NCBI Gene Model | MGI Sequence Detail 68806 C57BL/6J ±  kb
transcript NM_008555 RefSeq | MGI Sequence Detail 2752 Not Specified 
polypeptide P98064 UniProt | EBI | MGI Sequence Detail 704 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(8) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(668 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000859 CUB domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR024175 Peptidase S1A, complement C1r/C1S/mannan-binding
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR000436 Sushi/SCR/CCP
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000010193 mannan-binding lectin serine protease 1
Graphical View of Protein Domain Structure
References (Earliest) J:17689 Takahashi A, et al., Presence of a serine protease in the complement-activating component of the complement-dependent bactericidal factor, RaRF, in mouse serum. Biochem Biophys Res Commun. 1993 Feb 15;190(3):681-7
(Latest) J:209080 Ruseva MM, et al., C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo. Clin Exp Immunol. 2014 Apr;176(1):84-92
All references(41)
Other
accession IDs
MGD-MRK-2130, MGI:2146613

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory