Masp1
Gene Detail

Symbol

Name
ID

Masp1
mannan-binding lectin serine peptidase 1
MGI:88492

Synonyms

Crarf

Feature Type

protein coding gene

Genetic Map

Chromosome 16
14.23 cM, cytoband B2-B3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr16:23451785-23520590 bp, - strand From Ensembl annotation of GRCm38   68806 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:88793  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee

Protein SuperFamily: C1r-like complement-activating serine protease
Gene Tree: Masp1

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knockout allele display decreased survivor rate, reduced body weight, and impaired activation of the lectin and alternative complement pathways.

 

Interactions

Masp1 interacts with 132 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (19 annotations)

Process	complement activation, complement activation, lectin pathway, ...
Component	extracellular region, extracellular space
Function	calcium-dependent protein binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (16)    Tissues (13)    Tissue x Stage Matrix (view)

Assay Type	Results
RT-PCR	16

cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(54) cDNA(50) Primer pair(3) Other(1)
Microarray probesets(5)

Other database
links

Ensembl Gene Model	ENSMUSG00000022887 (Evidence)
Entrez Gene	17174 (Evidence)
UniGene	1213
DFCI	TC1579229, TC1618198
DoTS	DT.97356042, DT.40178722
NIA Mouse Gene Index	U036924
EC	3.4.21.-
Consensus CDS Project	CCDS37303.1
International Mouse Knockout Project Status	Masp1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022887	Ensembl Gene Model | MGI Sequence Detail	68806	C57BL/6J
transcript	ENSMUST00000089883	Ensembl | MGI Sequence Detail	2752	Not Applicable
polypeptide	ENSMUSP00000087327	Ensembl | MGI Sequence Detail	704	Not Applicable

All sequences(25) RefSeq(8) UniProt(1)

Polymorphisms

PCR(1) : SNPs within 2kb(668 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000859	CUB domain
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR024175	Peptidase S1A, complement C1r/C1S/mannan-binding
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR000436	Sushi/SCR/CCP
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000010193	mannan-binding lectin serine protease 1

References

(Earliest) J:17689 Takahashi A, et al., Presence of a serine protease in the complement-activating component of the complement-dependent bactericidal factor, RaRF, in mouse serum. Biochem Biophys Res Commun. 1993 Feb 15;190(3):681-7
(Latest) J:209080 Ruseva MM, et al., C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo. Clin Exp Immunol. 2014 Apr;176(1):84-92
All references(41)

Other
accession IDs

MGD-MRK-2130, MGI:2146613