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Cr2
Gene Detail
 Symbol
Name
ID
Cr2
complement receptor 2
MGI:88489
Synonyms C3DR, CD21, CD35, Cr1, Cr-1, Cr-2
Feature Type protein coding gene
Genetic Map
Chromosome 1
98.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr1:195136811-195176715 bp, - strand
From NCBI annotation of GRCm38

  39905 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55611  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Human
homologs
Human Homolog CR2, complement component (3d/Epstein Barr virus) receptor 2
NCBI Gene ID 1380
neXtProt AC  NX_P20023
Human Synonyms  C3DR, CD21, CR, CVID7, SLEB9
Human Chr (Location)  1q32; chr1:207454300-207489895 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human CR2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired humoral immune responses to T cell-dependent antigens, with limited affinity maturation, and reduced memory B cell and germinal center formation.
 
Interactions
Cr2 interacts with 345 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process B cell activation, B cell differentiation, ...
Component external side of plasma membrane, extracellular vesicular exosome, ...
Function complement binding, complement receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (42)    Tissues (35)   
Theiler Stages: 16, 18, 20, 21, 23, 25, 27, 28
Assay TypeResults
RT-PCR 42
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) Genomic(12) cDNA(36) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000094924 (Evidence), ENSMUSG00000026616 (Evidence)
Entrez Gene12902 (Evidence)
UniGene235387
DFCITC1586370, TC1597325, TC1599433, TC1601030
DoTSDT.91336425, DT.91336426, DT.94230296
NIA Mouse Gene IndexU022233
Consensus CDS ProjectCCDS15642.1
International Mouse Knockout Project StatusCr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12902 NCBI Gene Model | MGI Sequence Detail 39905 C57BL/6J ±  kb
transcript NM_007758 RefSeq | MGI Sequence Detail 6207 C57BL/6 
polypeptide P19070 UniProt | EBI | MGI Sequence Detail 1025 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(12) UniProt(5)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000001338 complement receptor type 2
Graphical View of Protein Domain Structure
References (Earliest) J:7312 Bubbers JE, Identification and linkage analyses of a gene, Rcs-1, suppressing spontaneous SJL/J lymphoma expression. J Natl Cancer Inst. 1984 Feb;72(2):441-6
(Latest) J:205353 Donius LR, et al., Optimal germinal center B cell activation and T-dependent antibody responses require expression of the mouse complement receptor Cr1. J Immunol. 2013 Jul 1;191(1):434-47
All references(143)
Other
accession IDs
MGD-MRK-2122, MGD-MRK-2123, MGD-MRK-2124, MGD-MRK-2125

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory