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Cr2 Gene Detail
Summary
  • Symbol
    Cr2
  • Name
    complement receptor 2
  • Synonyms
    C3DR, CD21, CD35, Cr1, Cr-1, Cr-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88489
    NCBI Gene: 12902
  • Gene Overview
    MyGene.info: CR2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:195136811-195176716 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 98.44 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88489
protein coding gene Chr1:195136811-195177190 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016969
protein coding gene Chr1:202319950-202361696 (-)
A/J MGP_AJ_G0016948
protein coding gene Chr1:194009170-194050263 (-)
AKR/J MGP_AKRJ_G0016913
protein coding gene Chr1:199750634-199790244 (-)
BALB/cJ MGP_BALBcJ_G0016906
protein coding gene Chr1:194709362-194755191 (-)
C3H/HeJ MGP_C3HHeJ_G0016730
protein coding gene Chr1:200643133-200694855 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017369
protein coding gene Chr1:208691087-208732026 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015076
protein coding gene Chr1:185402204-185440865 (-)
CAST/EiJ MGP_CASTEiJ_G0016313
protein coding gene Chr1:200201625-200248704 (-)
CBA/J MGP_CBAJ_G0016704
protein coding gene Chr1:216387468-216430616 (-)
DBA/2J MGP_DBA2J_G0016810
protein coding gene Chr1:192728921-192771485 (-)
FVB/NJ MGP_FVBNJ_G0016806
protein coding gene Chr1:190822077-190863084 (-)
LP/J MGP_LPJ_G0016885
protein coding gene Chr1:203449937-203494845 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016838
protein coding gene Chr1:223047359-223094913 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017406
protein coding gene Chr1:199595238-199636575 (-)
PWK/PhJ MGP_PWKPhJ_G0016100
protein coding gene Chr1:192038104-192081020 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015876
protein coding gene Chr1:198643653-198685024 (-)
WSB/EiJ MGP_WSBEiJ_G0016375
protein coding gene Chr1:199878547-199927507 (-)



Homology
more
  • Human Ortholog
    CR2, complement C3d receptor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CR2, complement C3d receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C3DR, CD21, CR, CVID7, SLEB9
  • Links
    NCBI Gene ID: 1380
    neXtProt AC: NX_P20023
    UniProt: P20023

  • Chr Location
    1q32.2; chr1:207454300-207489895 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human CR2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 6 alleles in 9 genetic backgrounds
    2 phenotypes from multigenic genotypes
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired humoral immune responses to T cell-dependent antigens, with limited affinity maturation, and reduced memory B cell and germinal center formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026616 Ensembl Gene Model | MGI Sequence Detail 39906 C57BL/6J ±  kb
    transcript ENSMUST00000210219 Ensembl | MGI Sequence Detail 4227 Not Applicable  
    polypeptide ENSMUSP00000147804 Ensembl | MGI Sequence Detail 1408 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • InterPro Domains
      IPR000436 Sushi/SCR/CCP domain
      IPR035976 Sushi/SCR/CCP superfamily
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 12
      cDNA 37
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2122, MGD-MRK-2123, MGD-MRK-2124, MGD-MRK-2125
    References
    more
    • Summaries
      All 163
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 81
    • Earliest
      J:7312 Bubbers JE, Identification and linkage analyses of a gene, Rcs-1, suppressing spontaneous SJL/J lymphoma expression. J Natl Cancer Inst. 1984 Feb;72(2):441-6
    • Latest
      J:264658 Riley SP, et al., Immunity against the Obligate Intracellular Bacterial Pathogen Rickettsia australis Requires a Functional Complement System. Infect Immun. 2018 Jun;86(6)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory