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Cr2
Gene Detail
Symbol

Name
ID
Cr2
complement receptor 2
MGI:88489
Synonyms
C3DR, CD21, CD35, Cr1, Cr-1, Cr-2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
98.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr1:195136811-195176716 bp, - strand
From VEGA annotation of GRCm38

  39906 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55611  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CR2
Gene Tree: Cr2

Human
homologs
CR2, complement component (3d/Epstein Barr virus) receptor 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1380
neXtProt AC: NX_P20023

Human Synonyms: C3DR, CD21, CR, CVID7, SLEB9

Human Chr (Location): 1q32; chr1:207454300-207489897 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human CR2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired humoral immune responses to T cell-dependent antigens, with limited affinity maturation, and reduced memory B cell and germinal center formation.
 
Interactions
Cr2 interacts with 345 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process B cell activation, B cell differentiation, ...
Component external side of plasma membrane, extracellular exosome, ...
Function complement binding, complement receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (42)    Tissues (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 42
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) Genomic(12) cDNA(36) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000050897 (Evidence)
Ensembl Gene Model ENSMUSG00000026616 (Evidence)
Entrez Gene 12902 (Evidence)
UniGene 235387
DFCI TC1586370, TC1597325, TC1599433, TC1601030
DoTS DT.91336425, DT.91336426, DT.94230296
NIA Mouse Gene Index U022233
Consensus CDS Project CCDS15642.1
International Mouse Phenotyping Consortium Status Cr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050897 VEGA Gene Model | MGI Sequence Detail 39906 C57BL/6J ±  kb
transcript OTTMUST00000128990 VEGA | MGI Sequence Detail 6212 Not Applicable 
polypeptide OTTMUSP00000069347 VEGA | MGI Sequence Detail 1026 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(13) UniProt(8)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000001338 complement receptor type 2
References
(Earliest) J:7312 Bubbers JE, Identification and linkage analyses of a gene, Rcs-1, suppressing spontaneous SJL/J lymphoma expression. J Natl Cancer Inst. 1984 Feb;72(2):441-6
(Latest) J:207583 Heesters BA, et al., Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation. Immunity. 2013 Jun 27;38(6):1164-75
All references(142)
Other
accession IDs
MGD-MRK-2122, MGD-MRK-2123, MGD-MRK-2124, MGD-MRK-2125

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory