Cr2
Gene Detail

Symbol Name ID

Cr2 complement receptor 2 MGI:88489

Synonyms

C3DR, CD21, CD35, Cr1, Cr-1, Cr-2

Feature Type

protein coding gene

Genetic Map

Chromosome 1

98.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr1:195136811-195176715 bp, - strand From NCBI annotation of GRCm38   39905 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55611  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Human homologs

Human Homolog		CR2, complement component (3d/Epstein Barr virus) receptor 2
NCBI Gene ID		1380
neXtProt AC		NX_P20023
Human Synonyms		C3DR, CD21, CR, CVID7, SLEB9
Human Chr (Location)		1q32; chr1:207627645-207663240 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human CR2

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygotes for targeted null mutations exhibit impaired humoral immune responses to T cell-dependent antigens, with limited affinity maturation, and reduced memory B cell and germinal center formation.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	B cell activation, complement activation, classical pathway, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	complement receptor activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (42)    Tissues (31)   
Theiler Stages: 16, 18, 20, 21, 23, 25, 28

Assay Type	Results
RT-PCR	42

cDNA source data(35)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(51) Genomic(12) cDNA(36) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000026616 (Evidence), ENSMUSG00000094924 (Evidence)
Entrez Gene	12902 (Evidence)
UniGene	235387
DFCI	TC1586370, TC1597325, TC1599433, TC1601030
DoTS	DT.91336425, DT.91336426, DT.94230296
NIA Mouse Gene Index	U022233
Consensus CDS Project	CCDS15642.1
International Mouse Knockout Project Status	Cr2

Sequences

Length	Strain/Species
genomic	12902	NCBI Gene Model | MGI Sequence Detail	39905	C57BL/6J
transcript	NM_007758	RefSeq | MGI Sequence Detail	6207	C57BL/6
polypeptide	P19070	UniProt | EBI | MGI Sequence Detail	1025	Not Applicable

All sequences(34) RefSeq(2) UniProt(5)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(152 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000436	Sushi/SCR/CCP
Protein Ontology	PR:000001338	complement receptor type 2

Graphical View of Protein Domain Structure

References

(Earliest) J:7312 Bubbers JE, Identification and linkage analyses of a gene, Rcs-1, suppressing spontaneous SJL/J lymphoma expression. J Natl Cancer Inst. 1984 Feb;72(2):441-6
(Latest) J:189689 Rutemark C, et al., Complement receptors 1 and 2 in murine antibody responses to IgM-complexed and uncomplexed sheep erythrocytes. PLoS One. 2012;7(7):e41968
All references(138)

Other accession IDs

MGD-MRK-2122, MGD-MRK-2123, MGD-MRK-2124, MGD-MRK-2125