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Cpa3
Gene Detail
Symbol

Name
ID
Cpa3
carboxypeptidase A3, mast cell
MGI:88479
Synonyms
mast cell carboxypeptidase A, MC-CPA, mMC-CPA
Feature Type
protein coding gene
Genetic Map
Chromosome 3
6.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:20215620-20242181 bp, - strand
From VEGA annotation of GRCm38

  26562 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:122138  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: CPA3
Protein SuperFamily: carboxypeptidase
Gene Tree: Cpa3

Human
homologs
CPA3, carboxypeptidase A3 (mast cell)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1359
neXtProt AC: NX_P15088

Human Synonyms: MC-CPA

Human Chr (Location): 3q24; chr3:148865256-148897087 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have immature peritoneal mast cells but normal mast cell functions.
 
Interactions
Cpa3 interacts with 57 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process positive regulation of defense response to virus by host, proteolysis, ...
Component cytoplasmic vesicle
Function carboxypeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (64)    Tissues (8)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
RT-PCR 24
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) Genomic(2) cDNA(37) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000051236 (Evidence)
Ensembl Gene Model ENSMUSG00000001865 (Evidence)
Entrez Gene 12873 (Evidence)
UniGene 1135
DFCI TC1579983
DoTS DT.531295
NIA Mouse Gene Index U023867
EC 3.4.17.1
Consensus CDS Project CCDS17262.1
International Mouse Phenotyping Consortium Status Cpa3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051236 VEGA Gene Model | MGI Sequence Detail 26562 C57BL/6J ±  kb
transcript OTTMUST00000129734 VEGA | MGI Sequence Detail 1449 Not Applicable 
polypeptide OTTMUSP00000069654 VEGA | MGI Sequence Detail 417 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(200 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000834 Peptidase M14, carboxypeptidase A
InterPro IPR003146 Proteinase inhibitor, carboxypeptidase propeptide
InterPro IPR009020 Proteinase inhibitor, propeptide
Protein Ontology PR:000005797 mast cell carboxypeptidase A
References
(Earliest) J:10117 Reynolds DS, et al., Isolation and molecular cloning of mast cell carboxypeptidase A. A novel member of the carboxypeptidase gene family. J Biol Chem. 1989 Nov 25;264(33):20094-9
(Latest) J:221184 Sulcova J, et al., Mast cells are dispensable in a genetic mouse model of chronic dermatitis. Am J Pathol. 2015 Jun;185(6):1575-87
All references(51)
Other
accession IDs
MGD-MRK-2103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory