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Cpa3
Gene Detail
 Symbol
Name
ID
Cpa3
carboxypeptidase A3, mast cell
MGI:88479
Synonyms mast cell carboxypeptidase A, MC-CPA, mMC-CPA
Feature Type protein coding gene
Genetic Map
Chromosome 3
6.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:20215617-20242181 bp, - strand
From Ensembl annotation of GRCm38

  26565 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:122138  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: carboxypeptidase
Gene Tree: Cpa3

Human
homologs
Human Homolog CPA3, carboxypeptidase A3 (mast cell)
NCBI Gene ID 1359
neXtProt AC  NX_P15088
Human Synonyms  MC-CPA
Human Chr (Location)  3q24; chr3:148865256-148897087 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have immature peritoneal mast cells but normal mast cell functions.
 
Interactions
Cpa3 interacts with 57 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process proteolysis, regulation of angiotensin levels in blood
Component cytoplasmic vesicle
Function carboxypeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (64)    Tissues (8)    Images (24)
Theiler Stages: 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 40
RT-PCR 24
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) Genomic(2) cDNA(37) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000001865 (Evidence)
Entrez Gene12873 (Evidence)
UniGene1135
DFCITC1579983
DoTSDT.531295
NIA Mouse Gene IndexU023867
EC3.4.17.1
Consensus CDS ProjectCCDS17262.1
International Mouse Knockout Project StatusCpa3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001865 Ensembl Gene Model | MGI Sequence Detail 26565 C57BL/6J ±  kb
transcript ENSMUST00000001921 Ensembl | MGI Sequence Detail 1452 Not Applicable 
polypeptide ENSMUSP00000001921 Ensembl | MGI Sequence Detail 417 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(200 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000834 Peptidase M14, carboxypeptidase A
InterPro IPR003146 Proteinase inhibitor, carboxypeptidase propeptide
InterPro IPR009020 Proteinase inhibitor, propeptide
Protein Ontology PR:000005797 mast cell carboxypeptidase A
References (Earliest) J:10117 Reynolds DS, et al., Isolation and molecular cloning of mast cell carboxypeptidase A. A novel member of the carboxypeptidase gene family. J Biol Chem. 1989 Nov 25;264(33):20094-9
(Latest) J:212200 Gomez-Pinilla PJ, et al., Mast cells play no role in the pathogenesis of postoperative ileus induced by intestinal manipulation. PLoS One. 2014;9(1):e85304
All references(48)
Other
accession IDs
MGD-MRK-2103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory