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Cp
Gene Detail
Symbol

Name
ID
Cp
ceruloplasmin
MGI:88476
Synonyms
D3Ertd555e
Feature Type
protein coding gene
Genetic Map
Chromosome 3
6.10 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr3:19957054-20009145 bp, + strand
From VEGA annotation of GRCm38

  52092 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ceruloplasmin-like multicopper ferroxidase
Gene Tree: Cp

Human
homologs
Human Homolog CP, ceruloplasmin (ferroxidase)
NCBI Gene ID 1356
neXtProt AC  NX_P00450
Human Synonyms  CP-2
Human Chr (Location)  3q23-q25; chr3:149162410-149222055 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CP
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit progressive accumulation of stored iron in the liver, spleen, cerebellum, and brainstem, mild iron deficiency anemia, and impaired motor coordination associated with loss of brainstem dopaminergic neurons.
 
Human Diseases Modeled Using Mouse Cp (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)
Interactions
Cp interacts with 243 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cellular iron ion homeostasis, copper ion transport, ...
Component anchored component of plasma membrane, blood microparticle, ...
Function chaperone binding, copper ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (250)    Tissues (169)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 156
Western blot 2
RT-PCR 92
cDNA source data(385)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(391) Genomic(3) cDNA(386) Primer pair(2)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000023513 (Evidence)
Ensembl Gene ModelENSMUSG00000003617 (Evidence)
Entrez Gene12870 (Evidence)
UniGene13787
DFCITC1572075, TC1606890, TC1609744, TC1641756, TC1684742
DoTSDT.101271213, DT.103570392, DT.40157911, DT.494465, DT.55181186, DT.91299530, DT.91334800, DT.97396260, DT.97410064
NIA Mouse Gene IndexU042412
EC1.16.3.1
Consensus CDS ProjectCCDS38400.1, CCDS38401.1, CCDS71227.1
International Mouse Knockout Project StatusCp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023513 VEGA Gene Model | MGI Sequence Detail 52092 C57BL/6J ±  kb
transcript OTTMUST00000057275 VEGA | MGI Sequence Detail 4092 Not Applicable 
polypeptide OTTMUSP00000027618 VEGA | MGI Sequence Detail 1085 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(9) UniProt(21)
Polymorphisms
SNPs within 2kb(356 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027150 Ceruloplasmin
InterPro IPR008972 Cupredoxin
InterPro IPR002355 Multicopper oxidase, copper-binding site
InterPro IPR001117 Multicopper oxidase, type 1
InterPro IPR011706 Multicopper oxidase, type 2
InterPro IPR011707 Multicopper oxidase, type 3
Protein Ontology PR:000005794 ceruloplasmin
References
(Earliest) J:7811 Baranov VS, et al., [Mapping of the ceruloplasmin gene on human and laboratory mouse chromosomes by direct in situ hybridization]. Genetika. 1985 Mar;21(3):409-19
(Latest) J:196714 Chapman AL, et al., Ceruloplasmin is an endogenous inhibitor of myeloperoxidase. J Biol Chem. 2013 Mar 1;288(9):6465-77
All references(72)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-2100, MGI:1261828

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory