About   Help   FAQ
Cp Gene Detail
Summary
  • Symbol
    Cp
  • Name
    ceruloplasmin
  • Synonyms
    D3Ertd555e
  • Feature Type
    protein coding gene
  • IDs
    MGI:88476
    NCBI Gene: 12870
  • Gene Overview
    MyGene.info: CP
Location & Maps
more
  • Sequence Map
    Chr3:19957054-20009145 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52092 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CP, ceruloplasmin (ferroxidase)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CP, ceruloplasmin (ferroxidase)
    Orthology source: HomoloGene
  • Synonyms
    CP-2
  • Links
    NCBI Gene ID: 1356
    neXtProt AC: NX_P00450

  • Chr Location
    3q23-q25; chr3:149162410-149222050 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cp mouse models; 1 with human CP associations

Human Disease Mouse Models
       Aceruloplasminemia   OMIM: 604290 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 6 alleles in 7 genetic backgrounds
    19 phenotypes from multigenic genotypes
    4 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Cp
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit progressive accumulation of stored iron in the liver, spleen, cerebellum, and brainstem, mild iron deficiency anemia, and impaired motor coordination associated with loss of brainstem dopaminergic neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023513 VEGA Gene Model | MGI Sequence Detail 52092 C57BL/6J ±  kb
transcript OTTMUST00000057275 VEGA | MGI Sequence Detail 4092 Not Applicable  
polypeptide OTTMUSP00000027618 VEGA | MGI Sequence Detail 1085 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    357 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 391
    Genomic 3
    cDNA 386
    Primer pair 2

    Microarray probesets 10
Other
Accession IDs
less
MGD-MRK-2100, MGI:1261828
References
more
  • Summaries
    All 68
    Developmental Gene Expression 6
    Diseases 5
    Gene Ontology 6
    Phenotypes 32
  • Earliest
    J:7811 Baranov VS, et al., [Mapping of the ceruloplasmin gene on human and laboratory mouse chromosomes by direct in situ hybridization]. Genetika. 1985 Mar;21(3):409-19
  • Latest
    J:226963 Jiang R, et al., Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain. J Nutr. 2015 May;145(5):1003-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory