Cp
Gene Detail

Symbol Name ID

Cp ceruloplasmin MGI:88476

Synonyms

D3Ertd555e

Feature Type

protein coding gene

Genetic Map

Chromosome 3

6.10 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr3:19957054-20009145 bp, + strand From VEGA annotation of GRCm38   52092 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:75  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ceruloplasmin-like multicopper ferroxidase
Gene Tree: Cp

Human homologs

Human Homolog		CP, ceruloplasmin (ferroxidase)
NCBI Gene ID		1356
neXtProt AC		NX_P00450
Human Synonyms		CP-2
Human Chr (Location)		3q23-q25; chr3:148880197-148939832 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CP

Alleles and phenotypes

All alleles(7) : Targeted(5) Spontaneous(1) Chemically induced(1)
 

Homozygotes for targeted null mutations exhibit progressive accumulation of stored iron in the liver, spleen, cerebellum, and brainstem, mild iron deficiency anemia, and impaired motor coordination associated with loss of brainstem dopaminergic neurons.

 
Human Diseases Modeled Using Mouse Cp (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	copper ion transport, ion transport, ...
Component	anchored to plasma membrane, extracellular region, ...
Function	chaperone binding, copper ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (250)    Tissues (169)    Images (28)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	156
Western blot	2
RT-PCR	92

cDNA source data(384)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(390) Genomic(3) cDNA(385) Primer pair(2)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000023513 (Evidence)
Ensembl Gene Model	ENSMUSG00000003617 (Evidence)
Entrez Gene	12870 (Evidence)
UniGene	13787
DFCI	TC1572075, TC1606890, TC1609744, TC1641756, TC1684742
DoTS	DT.101271213, DT.103570392, DT.40157911, DT.494465, DT.55181186, DT.91299530, DT.91334800, DT.97396260, DT.97410064
NIA Mouse Gene Index	U042412
EC	1.16.3.1
Consensus CDS Project	CCDS38400.1, CCDS38401.1
International Mouse Knockout Project Status	Cp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023513	VEGA Gene Model | MGI Sequence Detail	52092	C57BL/6J
transcript	OTTMUST00000057275	VEGA | MGI Sequence Detail	4092	Not Applicable
polypeptide	OTTMUSP00000027618	VEGA | MGI Sequence Detail	1085	Not Applicable

All sequences(100) RefSeq(8) UniProt(11)

Polymorphisms

SNPs(315 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008972	Cupredoxin
InterPro	IPR002355	Multicopper oxidase, copper-binding site
InterPro	IPR001117	Multicopper oxidase, type 1
InterPro	IPR011706	Multicopper oxidase, type 2
InterPro	IPR011707	Multicopper oxidase, type 3
Protein Ontology	PR:000005794	ceruloplasmin

References

(Earliest) J:7811 Baranov VS, et al., [Mapping of the ceruloplasmin gene on human and laboratory mouse chromosomes by direct in situ hybridization]. Genetika. 1985 Mar;21(3):409-19
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(70)

Other accession IDs

MGD-MRK-2100, MGI:1261828