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Cp
Gene Detail
Symbol

Name
ID
Cp
ceruloplasmin
MGI:88476
Synonyms
D3Ertd555e
Feature Type
protein coding gene
Genetic Map
Chromosome 3
6.10 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr3:19957054-20009145 bp, + strand
From VEGA annotation of GRCm38

  52092 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CP
Protein SuperFamily: ceruloplasmin-like multicopper ferroxidase
Gene Tree: Cp

Human
homologs
CP, ceruloplasmin (ferroxidase)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1356
neXtProt AC: NX_P00450

Human Synonyms: CP-2

Human Chr (Location): 3q23-q25; chr3:149162410-149222050 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CP

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit progressive accumulation of stored iron in the liver, spleen, cerebellum, and brainstem, mild iron deficiency anemia, and impaired motor coordination associated with loss of brainstem dopaminergic neurons.
 
Human Diseases Modeled in Mice Using Cp (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Cp interacts with 242 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cellular iron ion homeostasis, copper ion transport, ...
Component anchored component of plasma membrane, blood microparticle, ...
Function chaperone binding, copper ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (250)    Tissues (169)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 156
Western blot 2
RT-PCR 92
cDNA source data(385)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cp ; ZFIN cp    NEW 
Molecular
reagents
All nucleic(391) Genomic(3) cDNA(386) Primer pair(2)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000023513 (Evidence)
Ensembl Gene Model ENSMUSG00000003617 (Evidence)
Entrez Gene 12870 (Evidence)
UniGene 13787
DFCI TC1572075, TC1606890, TC1609744, TC1641756, TC1684742
DoTS DT.101271213, DT.103570392, DT.40157911, DT.494465, DT.55181186, DT.91299530, DT.91334800, DT.97396260, DT.97410064
NIA Mouse Gene Index U042412
EC 1.16.3.1
Consensus CDS Project CCDS38400.1, CCDS38401.1, CCDS71227.1
International Mouse Phenotyping Consortium Status Cp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023513 VEGA Gene Model | MGI Sequence Detail 52092 C57BL/6J ±  kb
transcript OTTMUST00000057275 VEGA | MGI Sequence Detail 4092 Not Applicable 
polypeptide OTTMUSP00000027618 VEGA | MGI Sequence Detail 1085 Not Applicable 

For the selected sequences
All sequences(103) RefSeq(11) UniProt(11)
Polymorphisms
SNPs within 2kb(356 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027150 Ceruloplasmin
InterPro IPR008972 Cupredoxin
InterPro IPR002355 Multicopper oxidase, copper-binding site
InterPro IPR001117 Multicopper oxidase, type 1
InterPro IPR011706 Multicopper oxidase, type 2
InterPro IPR011707 Multicopper oxidase, type 3
Protein Ontology PR:000005794 ceruloplasmin
References
(Earliest) J:7811 Baranov VS, et al., [Mapping of the ceruloplasmin gene on human and laboratory mouse chromosomes by direct in situ hybridization]. Genetika. 1985 Mar;21(3):409-19
(Latest) J:221457 You LH, et al., Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson's disease. Neuroscience. 2015 Jan 22;284:234-46
All references(70)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-2100, MGI:1261828

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory