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Cox5b Gene Detail
Summary
  • Symbol
    Cox5b
  • Name
    cytochrome c oxidase subunit 5B
  • Feature Type
    protein coding gene
  • IDs
    MGI:88475
    NCBI Gene: 12859
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:36730568-36732469 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 15.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    153 from dbSNP Build 142
  • Strain Annotations
    38
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88475
 protein coding gene Chr1:36730530-36732762 (+)
129S1/SvImJ ENSMUSG00200023012
 protein coding gene Chr12:16539695-16540084 (+)
129S1/SvImJ ENSMUSG00200003758
 protein coding gene Chr1:34318950-34321182 (+)
129S1/SvImJ ENSMUSG00200012182
 protein coding gene Chr13:18884116-18884505 (-)
A/J ENSMUSG00195040831
 protein coding gene Chr1:33939090-33941320 (+)
A/J ENSMUSG00195016369
 protein coding gene Chr12:19264891-19265280 (+)
A/J ENSMUSG00195034199
 protein coding gene Chr13:18028110-18028499 (-)
AKR/J ENSMUSG00220025122
 protein coding gene Chr12:17215164-17215553 (+)
AKR/J ENSMUSG00220027568
 protein coding gene Chr13:17943466-17943855 (-)
AKR/J ENSMUSG00220008468
 protein coding gene Chr1:33961062-33963293 (+)
BALB/cJ ENSMUSG00180008838
 protein coding gene Chr12:18207535-18207924 (+)
BALB/cJ ENSMUSG00180031988
 protein coding gene Chr13:18389397-18389786 (-)
BALB/cJ ENSMUSG00180011137
 protein coding gene Chr1:34064281-34066513 (+)
C3H/HeJ ENSMUSG00175028607
 protein coding gene Chr13:18494532-18494921 (-)
C3H/HeJ ENSMUSG00175001198
 protein coding gene Chr1:33943184-33945416 (+)
C57BL/6NJ ENSMUSG00215014815
 protein coding gene Chr1:34041251-34043483 (+)
C57BL/6NJ ENSMUSG00215019378
 protein coding gene Chr13:18441173-18441562 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014043
 protein coding gene Chr1:31345508-31347626 (+)
CAST/EiJ ENSTCUG00005002708
 protein coding gene Chr1:34117798-34120062 (+)
CBA/J ENSMUSG00210029040
 protein coding gene Chr13:18356089-18356478 (-)
CBA/J ENSMUSG00210005339
 protein coding gene Chr1:33786325-33788556 (+)
DBA/2J ENSMUSG00185003539
 protein coding gene Chr12:19781208-19781597 (+)
DBA/2J ENSMUSG00185009734
 protein coding gene Chr1:34870679-34872911 (+)
DBA/2J ENSMUSG00185013396
 protein coding gene Chr13:19050457-19050846 (-)
FVB/NJ ENSMUSG00205001360
 protein coding gene Chr12:17850602-17850991 (+)
FVB/NJ ENSMUSG00205021630
 protein coding gene Chr13:18199915-18200304 (-)
FVB/NJ ENSMUSG00205027038
 protein coding gene Chr1:33965269-33967500 (+)
JF1/MsJ ENSUMUG00000016179
 protein coding gene Chr1:34085276-34087568 (+)
LP/J ENSMUSG00230033921
 protein coding gene Chr13:28444500-28444889 (-)
LP/J ENSMUSG00230006139
 protein coding gene Chr12:26748343-26748732 (+)
LP/J ENSMUSG00230023453
 protein coding gene Chr1:34939770-34942002 (+)
NOD/ShiLtJ ENSMUSG00190019564
 protein coding gene Chr13:18309270-18309659 (-)
NOD/ShiLtJ ENSMUSG00190012626
 protein coding gene Chr12:16714528-16714917 (+)
NOD/ShiLtJ ENSMUSG00190026862
 protein coding gene Chr1:33981365-33983597 (+)
NZO/HlLtJ ENSMUSG00225034129
 protein coding gene Chr12:28931448-28931837 (+)
NZO/HlLtJ ENSMUSG00225013760
 protein coding gene Chr1:38174391-38176622 (+)
NZO/HlLtJ ENSMUSG00225044689
 protein coding gene Chr13:22205340-22205729 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010028284
 protein coding gene Chr1:35099438-35101446 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    COX5B, cytochrome c oxidase subunit 5B
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX5B, cytochrome c oxidase subunit 5B
  • Synonyms
    COXVB
  • Links
    NCBI Gene ID: 1329
    UniProt: P10606

  • Chr Location
    2q11.2; chr2:97646062-97648383 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    109
  • cDNA Data
    6
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12859 NCBI Gene Model | MGI Sequence Detail 1902 C57BL/6J ±  kb
    transcript NM_009942 RefSeq | MGI Sequence Detail 584 C57BL/6  
    polypeptide P19536 UniProt | EBI | MGI Sequence Detail 128 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 5
      cDNA 6
      Primer pair 3
      Antibodies 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-2099
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 14
      Gene Ontology 13
      Phenotypes 13
    • Earliest
      J:10015 Nielsen PJ, et al., Nucleotide sequence of cDNA encoding mouse cytochrome c oxidase subunit Va. Nucleic Acids Res. 1989 Aug 25;17(16):6723
    • Latest
      J:363294 Wang S, et al., SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice. Cell Death Differ. 2025 Mar;32(3):447-465
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory