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Cox5a Gene Detail
Summary
  • Symbol
    Cox5a
  • Name
    cytochrome c oxidase subunit 5A
  • Synonyms
    CcOX
  • Feature Type
    protein coding gene
  • IDs
    MGI:88474
    NCBI Gene: 12858
  • Gene Overview
    MyGene.info: COX5A
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57521274-57532426 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 31.05 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88474
protein coding gene Chr9:57521232-57532427 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034867
protein coding gene Chr9:56733661-56746119 (+)
A/J MGP_AJ_G0034848
protein coding gene Chr9:54905389-54917115 (+)
AKR/J MGP_AKRJ_G0034777
protein coding gene Chr9:56159847-56174442 (+)
BALB/cJ MGP_BALBcJ_G0034840
protein coding gene Chr9:54690629-54702409 (+)
C3H/HeJ MGP_C3HHeJ_G0034550
protein coding gene Chr9:56652346-56663845 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035359
protein coding gene Chr9:58316975-58330006 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032270
protein coding gene Chr9:54212315-54222813 (+)
CAST/EiJ MGP_CASTEiJ_G0033871
protein coding gene Chr9:56736975-56749542 (+)
CBA/J MGP_CBAJ_G0034521
protein coding gene Chr9:60352885-60364047 (+)
DBA/2J MGP_DBA2J_G0034680
protein coding gene Chr9:54771697-54782655 (+)
FVB/NJ MGP_FVBNJ_G0034622
protein coding gene Chr9:53998674-54010306 (+)
LP/J MGP_LPJ_G0034763
protein coding gene Chr9:57032197-57044066 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034665
protein coding gene Chr9:61850416-61863866 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035381
protein coding gene Chr9:56188382-56199407 (+)
PWK/PhJ MGP_PWKPhJ_G0033576
protein coding gene Chr9:54802791-54814201 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033410
protein coding gene Chr9:56479505-56490414 (+)
WSB/EiJ MGP_WSBEiJ_G0033984
protein coding gene Chr9:56121152-56133178 (+)



Homology
more
  • Human Ortholog
    COX5A, cytochrome c oxidase subunit 5A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    COX5A, cytochrome c oxidase subunit 5A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COX, COX-VA, VA
  • Links
    NCBI Gene ID: 9377
    neXtProt AC: NX_P20674
    UniProt: P20674

  • Chr Location
    15q24.2; chr15:74920275-74938154 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000088 Ensembl Gene Model | MGI Sequence Detail 11153 C57BL/6J ±  kb
transcript ENSMUST00000000090 Ensembl | MGI Sequence Detail 645 Not Applicable  
polypeptide ENSMUSP00000000090 Ensembl | MGI Sequence Detail 146 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005779 cytochrome c oxidase subunit 5A, mitochondrial
  • InterPro Domains
    IPR003204 Cytochrome c oxidase, subunit Va/VI
    IPR036545 Cytochrome c oxidase, subunit Va/VI superfamily
Molecular
Reagents
less
  • All nucleic 358
    cDNA 354
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-2098, MGI:2144051
References
more
  • Summaries
    All 59
    Developmental Gene Expression 7
    Gene Ontology 12
    Phenotypes 5
  • Earliest
    J:20269 Wright RM, et al., Isolation and sequence of the structural gene for cytochrome c oxidase subunit VI from Saccharomyces cerevisiae. J Biol Chem. 1984 Dec 25;259(24):15401-7
  • Latest
    J:195548 Brody MJ, et al., Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. PLoS One. 2012;7(12):e51621

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory