Comp
Gene Detail

Symbol Name ID

Comp cartilage oligomeric matrix protein MGI:88469

Synonyms

thrombospondin-5, TSP5

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:70373548-70382065 bp, + strand From Ensembl annotation of GRCm38   8518 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: thrombospondin 3
Gene Tree: Comp

Human homologs

Human Homolog		COMP, cartilage oligomeric matrix protein
NCBI Gene ID		1311
neXtProt AC		NX_P49747
Human Synonyms		EDM1, EPD1, MED, PSACH, THBS5
Human Chr (Location)		19p13.1; chr19:18893583-18902114 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human COMP

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a targeted null mutation are indistinguishable from controls. Mice homozygous for a knockin allele with two point mutations exhibit short limb dwarfism, osteoarthritis, abnormal chondrocytes, mild myopathy, and abnormal tendon morphology and stiffness.

 
Human Diseases Modeled Using Mouse Comp (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	apoptotic process, cell adhesion, ...
Component	extracellular matrix, extracellular region, ...
Function	calcium ion binding, collagen binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (35)    Tissues (26)   
Theiler Stages: 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	2
Northern blot	32

cDNA source data(18)
External Resources: GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(18) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000031849 (Evidence)
Entrez Gene	12845 (Evidence)
UniGene	45071
DFCI	TC1577575
DoTS	DT.99849918
NIA Mouse Gene Index	U135840
PDB	1MZ9
Consensus CDS Project	CCDS22367.1
International Mouse Knockout Project Status	Comp

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031849	Ensembl Gene Model | MGI Sequence Detail	8518	C57BL/6J
transcript	ENSMUST00000003659	Ensembl | MGI Sequence Detail	2425	Not Applicable
polypeptide	ENSMUSP00000003659	Ensembl | MGI Sequence Detail	755	Not Applicable

All sequences(17) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(37 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR024665	Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
InterPro	IPR008859	Thrombospondin, C-terminal
InterPro	IPR003367	Thrombospondin, type 3-like repeat
InterPro	IPR017897	Thrombospondin, type 3 repeat
Protein Ontology	PR:000000085	cartilage oligomeric matrix protein

References

(Earliest) J:22324 Newton G, et al., Characterization of human and mouse cartilage oligomeric matrix protein. Genomics. 1994 Dec;24(3):435-9
(Latest) J:182166 Liu CF, et al., Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon. Tissue Eng Part A. 2012 Mar;18(5-6):598-608
All references(51)

Other accession IDs

MGD-MRK-2091