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Comp
Gene Detail
Symbol

Name
ID
Comp
cartilage oligomeric matrix protein
MGI:88469
Synonyms
thrombospondin-5, TSP5
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:70373548-70382065 bp, + strand
From Ensembl annotation of GRCm38

  8518 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: COMP
Protein SuperFamily: thrombospondin 3
Gene Tree: Comp

Human
homologs
COMP, cartilage oligomeric matrix protein
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1311
neXtProt AC: NX_P49747

Human Synonyms: EDM1, EPD1, MED, PSACH, THBS5

Human Chr (Location): 19p13.1; chr19:18782773-18791305 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human COMP

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted null mutation are indistinguishable from controls. Mice homozygous for a knockin allele with two point mutations exhibit short limb dwarfism, osteoarthritis, abnormal chondrocytes, mild myopathy, and abnormal tendon morphology and stiffness.
 
Human Diseases Modeled in Mice Using Comp (2)    Mutations Annotated to Human Diseases (3)   
Interactions
Comp interacts with 18 markers (Mir99a, Mir99b, Mir100, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process apoptotic process, cell adhesion, ...
Component extracellular exosome, extracellular matrix, ...
Function calcium ion binding, collagen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (35)    Tissues (26)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 2
Northern blot 32
cDNA source data(18)
Other mouse links: GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase comp    NEW 
Molecular
reagents
All nucleic(19) cDNA(18) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000031849 (Evidence)
Entrez Gene 12845 (Evidence)
UniGene 45071
DFCI TC1577575
DoTS DT.99849918
NIA Mouse Gene Index U135840
PDB 3V2N, 3V2P, 3V2Q, 3V2R, 1MZ9
Consensus CDS Project CCDS22367.1
International Mouse Phenotyping Consortium Status Comp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031849 Ensembl Gene Model | MGI Sequence Detail 8518 C57BL/6J ±  kb
transcript ENSMUST00000003659 Ensembl | MGI Sequence Detail 2425 Not Applicable 
polypeptide ENSMUSP00000003659 Ensembl | MGI Sequence Detail 755 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR024665 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
InterPro IPR008859 Thrombospondin, C-terminal
InterPro IPR003367 Thrombospondin, type 3-like repeat
InterPro IPR017897 Thrombospondin, type 3 repeat
Protein Ontology PR:000000085 cartilage oligomeric matrix protein
References
(Earliest) J:22324 Newton G, et al., Characterization of human and mouse cartilage oligomeric matrix protein. Genomics. 1994 Dec;24(3):435-9
(Latest) J:215399 Posey KL, et al., Pseudoachondroplasia/COMP - translating from the bench to the bedside. Matrix Biol. 2014 Jul;37:167-73
All references(58)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-2091

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory