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Comp Gene Detail
Summary
  • Symbol
    Comp
  • Name
    cartilage oligomeric matrix protein
  • Synonyms
    thrombospondin-5, TSP5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88469
    NCBI Gene: 12845
Location & Maps
more
  • Sequence Map
    Chr8:70373548-70382065 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8518 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    COMP, cartilage oligomeric matrix protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    COMP, cartilage oligomeric matrix protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EDM1, EPD1, MED, PSACH, THBS5
  • Links
    NCBI Gene ID: 1311
    neXtProt AC: NX_P49747

  • Chr Location
    19p13.1; chr19:18782773-18791305 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Comp mouse models; 2 with human COMP associations

Human Disease Mouse Models
       Epiphyseal Dysplasia, Multiple, 1; EDM1   OMIM: 132400 View 1 model
Pseudoachondroplasia; PSACH   OMIM: 177170 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    1 involving Comp
  • Incidental Mutations
Mice homozygous for a targeted null mutation are indistinguishable from controls. Mice homozygous for a knockin allele with two point mutations exhibit short limb dwarfism, osteoarthritis, abnormal chondrocytes, mild myopathy, and abnormal tendon morphology and stiffness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031849 Ensembl Gene Model | MGI Sequence Detail 8518 C57BL/6J ±  kb
transcript ENSMUST00000003659 Ensembl | MGI Sequence Detail 2425 Not Applicable  
polypeptide ENSMUSP00000003659 Ensembl | MGI Sequence Detail 755 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    55 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 18
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-2091
References
more
  • Summaries
    All 60
    Developmental Gene Expression 23
    Diseases 5
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:22324 Newton G, et al., Characterization of human and mouse cartilage oligomeric matrix protein. Genomics. 1994 Dec;24(3):435-9
  • Latest
    J:230573 Kessler T, et al., ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1. Circulation. 2015 Mar 31;131(13):1191-201

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory