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Comp Gene Detail
Summary
  • Symbol
    Comp
  • Name
    cartilage oligomeric matrix protein
  • Synonyms
    thrombospondin-5, TSP5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88469
    NCBI Gene: 12845
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70373558-70382066 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88469
protein coding gene Chr8:70373548-70382066 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033703
protein coding gene Chr8:70639244-70647842 (+)
A/J MGP_AJ_G0033686
protein coding gene Chr8:67768207-67776787 (+)
AKR/J MGP_AKRJ_G0033611
protein coding gene Chr8:69695826-69704423 (+)
BALB/cJ MGP_BALBcJ_G0033682
protein coding gene Chr8:67988948-67997576 (+)
C3H/HeJ MGP_C3HHeJ_G0033392
protein coding gene Chr8:70341305-70349976 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034199
protein coding gene Chr8:73309684-73318191 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031143
protein coding gene Chr8:62585120-62593542 (+)
CAST/EiJ MGP_CASTEiJ_G0032717
protein coding gene Chr8:69827054-69835592 (+)
CBA/J MGP_CBAJ_G0033370
protein coding gene Chr8:75939556-75948154 (+)
DBA/2J MGP_DBA2J_G0033524
protein coding gene Chr8:67489054-67497682 (+)
FVB/NJ MGP_FVBNJ_G0033465
protein coding gene Chr8:66599698-66608315 (+)
LP/J MGP_LPJ_G0033611
protein coding gene Chr8:70666683-70675281 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033508
protein coding gene Chr8:78608332-78616810 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034217
protein coding gene Chr8:69882700-69891298 (+)
PWK/PhJ MGP_PWKPhJ_G0032425
protein coding gene Chr8:66785078-66793694 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032261
protein coding gene Chr8:68851086-68859642 (+)
WSB/EiJ MGP_WSBEiJ_G0032832
protein coding gene Chr8:70240550-70249195 (+)



Homology
more
  • Human Ortholog
    COMP, cartilage oligomeric matrix protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    COMP, cartilage oligomeric matrix protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EDM1, EPD1, MED, PSACH, THBS5, TSP5
  • Links
    NCBI Gene ID: 1311
    neXtProt AC: NX_P49747
    UniProt: P49747

  • Chr Location
    19p13.11; chr19:18782773-18791305 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Comp mouse models; 1 with human COMP associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are indistinguishable from controls. Mice homozygous for a knockin allele with two point mutations exhibit short limb dwarfism, osteoarthritis, abnormal chondrocytes, mild myopathy, and abnormal tendon morphology and stiffness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031849 Ensembl Gene Model | MGI Sequence Detail 8509 C57BL/6J ±  kb
    transcript ENSMUST00000003659 Ensembl | MGI Sequence Detail 2416 Not Applicable  
    polypeptide ENSMUSP00000003659 Ensembl | MGI Sequence Detail 755 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-2091
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 23
      Diseases 6
      Gene Ontology 23
      Phenotypes 26
    • Earliest
      J:22324 Newton G, et al., Characterization of human and mouse cartilage oligomeric matrix protein. Genomics. 1994 Dec;24(3):435-9
    • Latest
      J:263967 Coustry F, et al., Mutant cartilage oligomeric matrix protein (COMP) compromises bone integrity, joint function and the balance between adipogenesis and osteogenesis. Matrix Biol. 2018 Apr;67:75-89

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory