Col18a1
Gene Detail

Symbol Name ID

Col18a1 collagen, type XVIII, alpha 1 MGI:88451

Synonyms

endostatin

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM, cytoband B5-C1
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr10:77052178-77166548 bp, - strand From VEGA annotation of GRCm38   114371 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7673  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Col18a1

Human homologs

Human Homolog		COL18A1, collagen, type XVIII, alpha 1
NCBI Gene ID		80781
neXtProt AC		NX_P39060
Human Synonyms		KNO, KNO1, KS
Human Chr (Location)		21q22.3; chr21:46825097-46933634 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human COL18A1

Alleles and phenotypes

All alleles(176) : Targeted(7) Gene trapped(169)
 

Mice homozygous for a knock-out allele exhibit defects in hyaloid vessel regression, attenuated visual function, abnormal electroretinograms, broad proximal tubule basement membrane, podocyte effacement, and softened glomeruli.

 
Human Diseases Modeled Using Mouse Col18a1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	angiogenesis, cell adhesion, ...
Component	basement membrane, collagen, ...
Function	identical protein binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (30 records)
Data Summary: Results (593)    Tissues (285)    Images (73)
Theiler Stages: 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	23
RNA in situ	512
Northern blot	36
Western blot	4
RT-PCR	18

cDNA source data(343)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(372) Genomic(20) cDNA(344) Primer pair(3) Other(5)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000021408 (Evidence)
Ensembl Gene Model	ENSMUSG00000001435 (Evidence)
Entrez Gene	12822 (Evidence)
UniGene	4352
DFCI	TC1571925, TC1628096
DoTS	DT.101184729, DT.101738479, DT.535448, DT.87039032
NIA Mouse Gene Index	U031954
PDB	1KOE, 1DY0, 1DY1
Consensus CDS Project	CCDS23953.1, CCDS48604.1
International Mouse Knockout Project Status	Col18a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021408	VEGA Gene Model | MGI Sequence Detail	114371	C57BL/6J
transcript	OTTMUST00000050740	VEGA | MGI Sequence Detail	4791	Not Applicable
polypeptide	OTTMUSP00000023766	VEGA | MGI Sequence Detail	1527	Not Applicable

All sequences(73) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(825 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026917	Collagen alpha-1(XVIII) chain
InterPro	IPR010515	Collagenase NC10/endostatin
InterPro	IPR008160	Collagen triple helix repeat
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR016187	C-type lectin fold
InterPro	IPR016186	C-type lectin-like
InterPro	IPR010363	Domain of unknown function DUF959, collagen XVIII, N-terminal
InterPro	IPR020067	Frizzled domain
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR001791	Laminin G domain
Protein Ontology	PR:000005702	collagen alpha-1(XVIII) chain

References

(Earliest) J:15411 Abe N, et al., Identification of a novel collagen chain represented by extensive interruptions in the triple-helical region. Biochem Biophys Res Commun. 1993 Oct 29;196(2):576-82
(Latest) J:188916 Brohl D, et al., Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals. Dev Cell. 2012 Sep 11;23(3):469-81
All references(101)

Other accession IDs

MGD-MRK-2058