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Col15a1
Gene Detail
Symbol

Name
ID
Col15a1
collagen, type XV, alpha 1
MGI:88449
Feature Type
protein coding gene
Genetic Map
Chromosome 4
26.01 cM, cytoband B1-B3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:47208161-47313167 bp, + strand
From VEGA annotation of GRCm38

  105007 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1396  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: COL15A1
Gene Tree: Col15a1

Human
homologs
COL15A1, collagen, type XV, alpha 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1306
neXtProt AC: NX_P39059

Human Chr (Location): 9q21-q22; chr9:98943348-99070792 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in abnormal muscle cells of variable size (including atrophic and split muscle cells), susceptibility to exercise-induced muscle injury, and abnormalities in heart and skeletal muscle capillary endothelium.
 
Phenotype Images(2)
Interactions
Col15a1 interacts with 200 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell adhesion
Component basement membrane, collagen trimer, ...
Function structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (220)    Tissues (40)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 205
Northern blot 12
RT-PCR 3
cDNA source data(96)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN col15a1a, col15a1b    NEW 
Molecular
reagents
All nucleic(100) Genomic(2) cDNA(97) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006798 (Evidence)
Ensembl Gene Model ENSMUSG00000028339 (Evidence)
Entrez Gene 12819 (Evidence)
UniGene 233547
DFCI TC1576508, TC1667853
DoTS DT.101172590, DT.101389520, DT.492086, DT.94294806, DT.94294810
NIA Mouse Gene Index U004297
PDB 1DY2
Consensus CDS Project CCDS18159.1
International Mouse Phenotyping Consortium Status Col15a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006798 VEGA Gene Model | MGI Sequence Detail 105007 C57BL/6J ±  kb
transcript OTTMUST00000015661 VEGA | MGI Sequence Detail 5172 Not Applicable 
polypeptide OTTMUSP00000007202 VEGA | MGI Sequence Detail 1367 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(8) UniProt(6)
Polymorphisms
SNPs within 2kb(510 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010515 Collagenase NC10/endostatin
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000005699 collagen alpha-1(XV) chain
References
(Earliest) J:15411 Abe N, et al., Identification of a novel collagen chain represented by extensive interruptions in the triple-helical region. Biochem Biophys Res Commun. 1993 Oct 29;196(2):576-82
(Latest) J:217959 Rygh CB, et al., Image-based assessment of microvascular function and structure in collagen XV- and XVIII-deficient mice. J Physiol. 2014 Jan 15;592(Pt 2):325-36
All references(48)
Other
accession IDs
MGD-MRK-2056

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory