Col10a1
Gene Detail

Symbol Name ID

Col10a1 collagen, type X, alpha 1 MGI:88445

Synonyms

Col10, Col10a-1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

18.85 cM, cytoband B1-B3
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr10:34389981-34397085 bp, + strand From VEGA annotation of GRCm38   7105 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55466  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Col10a1

Human homologs

Human Homolog		COL10A1, collagen, type X, alpha 1
NCBI Gene ID		1300
neXtProt AC		NX_Q03692
Human Chr (Location)		6q21-q22; chr6:116440085-116447296 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human COL10A1

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygotes for targeted null mutations may exhibit abnormal trabecular bone, thinner growth plate resting zone and articular cartilage, and altered bone content.

 
Human Diseases Modeled Using Mouse Col10a1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	cartilage development, endochondral ossification
Component	cell cortex, collagen, ...

External Resources: FuncBase

Expression

Literature Summary: (305 records)
Data Summary: Results (231)    Tissues (89)    Images (116)
Theiler Stages: 16, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	206
Northern blot	5
RT-PCR	10

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(59) Genomic(19) cDNA(22) Primer pair(6) Other(12)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000022505 (Evidence)
Ensembl Gene Model	ENSMUSG00000039462 (Evidence)
Entrez Gene	12813 (Evidence)
UniGene	443177
DFCI	TC1586596, TC1685686
DoTS	DT.110588399, DT.99850740
NIA Mouse Gene Index	U011398
Consensus CDS Project	CCDS23780.1
International Mouse Knockout Project Status	Col10a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022505	VEGA Gene Model | MGI Sequence Detail	7105	C57BL/6J
transcript	OTTMUST00000053879	VEGA | MGI Sequence Detail	3130	Not Applicable
polypeptide	OTTMUSP00000025645	VEGA | MGI Sequence Detail	680	Not Applicable

All sequences(24) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(39 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008160	Collagen triple helix repeat
InterPro	IPR001073	Complement C1q protein
InterPro	IPR008983	Tumour necrosis factor-like domain
Protein Ontology	PR:000005693	collagen alpha-1(X) chain

References

(Earliest) J:717 Elima K, et al., Specific hybridization probes for mouse alpha 2(IX) and alpha 1(X) collagen mRNAs. Biochim Biophys Acta. 1992 Feb 28;1130(1):78-80
(Latest) J:194983 Ideno H, et al., Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development. Gene Expr Patterns. 2013 Mar-Apr;13(3-4):84-90
All references(356)

Other accession IDs

MGD-MRK-2051, MGD-MRK-2052