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Col10a1
Gene Detail
Symbol

Name
ID
Col10a1
collagen, type X, alpha 1
MGI:88445
Synonyms
Col10, Col10a-1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
18.85 cM, cytoband B1-B3
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr10:34389981-34397085 bp, + strand
From VEGA annotation of GRCm38

  7105 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55466  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: COL10A1
Gene Tree: Col10a1

Human
homologs
COL10A1, collagen, type X, alpha 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1300
neXtProt AC: NX_Q03692

Human Chr (Location): 6q21-q22; chr6:116118909-116218169 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human COL10A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations may exhibit abnormal trabecular bone, thinner growth plate resting zone and articular cartilage, and altered bone content.
 
Human Diseases Modeled in Mice Using Col10a1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Col10a1 interacts with 203 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component cell cortex, collagen trimer, ...
External Resources: FuncBase
Expression
Literature Summary: (354 records)
Data Summary: Results (300)    Tissues (101)    Images (168)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 24
RNA in situ 257
Northern blot 5
RT-PCR 14
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN col10a1a    NEW 
Molecular
reagents
All nucleic(66) Genomic(19) cDNA(25) Primer pair(7) Other(15)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022505 (Evidence)
Ensembl Gene Model ENSMUSG00000039462 (Evidence)
Entrez Gene 12813 (Evidence)
UniGene 443177
DFCI TC1586596, TC1685686
DoTS DT.110588399, DT.99850740
NIA Mouse Gene Index U011398
Consensus CDS Project CCDS23780.1
International Mouse Phenotyping Consortium Status Col10a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022505 VEGA Gene Model | MGI Sequence Detail 7105 C57BL/6J ±  kb
transcript OTTMUST00000053879 VEGA | MGI Sequence Detail 3130 Not Applicable 
polypeptide OTTMUSP00000025645 VEGA | MGI Sequence Detail 680 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR001073 Complement C1q protein
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000005693 collagen alpha-1(X) chain
References
(Earliest) J:717 Elima K, et al., Specific hybridization probes for mouse alpha 2(IX) and alpha 1(X) collagen mRNAs. Biochim Biophys Acta. 1992 Feb 28;1130(1):78-80
(Latest) J:220312 Sugita S, et al., Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3080-5
All references(403)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-2051, MGD-MRK-2052

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory