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Cnga1
Gene Detail
 Symbol
Name
ID
Cnga1
cyclic nucleotide gated channel alpha 1
MGI:88436
Synonyms Cncg
Feature Type protein coding gene
Genetic Map
Chromosome 5
38.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:72603696-72642752 bp, - strand
From VEGA annotation of GRCm38

  39057 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cyclic nucleotide-gated channel, alpha subunit
Gene Tree: Cnga1

Human
homologs
Human Homolog CNGA1, cyclic nucleotide gated channel alpha 1
NCBI Gene ID 1259
neXtProt AC  NX_P29973
Human Synonyms  CNCG, CNCG1, CNG1, CNG-1, RCNC1, RCNCa, RCNCalpha, RP49
Human Chr (Location)  4p12; chr4:47935977-48016629 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CNGA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cnga1 interacts with 93 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cation transmembrane transport, cytosolic calcium ion homeostasis, ...
Component cytoplasm, cytosol, ...
Function cGMP binding, intracellular cAMP activated cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (2)    Images (2)
Theiler Stages: 28
Assay TypeResults
RNA in situ 2
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026745 (Evidence)
Ensembl Gene ModelENSMUSG00000067220 (Evidence)
Entrez Gene12788 (Evidence)
DFCITC1586133, TC1593627, TC1613782
DoTSDT.40156464, DT.94126166, DT.94126170
Consensus CDS ProjectCCDS19333.1
International Mouse Knockout Project StatusCnga1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026745 VEGA Gene Model | MGI Sequence Detail 39057 C57BL/6J ±  kb
transcript OTTMUST00000066148 VEGA | MGI Sequence Detail 2739 Not Applicable 
polypeptide OTTMUSP00000033101 VEGA | MGI Sequence Detail 684 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(298 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000686 cGMP-gated cation channel alpha-1
References (Earliest) J:2297 Altherr MR, et al., Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase beta-subunit gene in mouse and human: tight linkage to the Huntington disease region (4p16.3). Genomics. 1992 Apr;12(4):750-4
(Latest) J:179991 Cisneros-Mejorado A, et al., cGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation. FEBS Lett. 2012 Jan 20;586(2):149-53
All references(39)
Other
accession IDs
MGD-MRK-2038

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory