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Cnga1 Gene Detail
Summary
  • Symbol
    Cnga1
  • Name
    cyclic nucleotide gated channel alpha 1
  • Synonyms
    Cncg
  • Feature Type
    protein coding gene
  • IDs
    MGI:88436
    NCBI Gene: 12788
Location & Maps
more
  • Sequence Map
    Chr5:72603696-72644275 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40580 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CNGA1, cyclic nucleotide gated channel alpha 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CNGA1, cyclic nucleotide gated channel alpha 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CNCG, CNCG1, CNG1, CNG-1, RCNC1, RCNCa, RCNCalpha, RP49
  • Links
    NCBI Gene ID: 1259
    neXtProt AC: NX_P29973

  • Chr Location
    4p12; chr4:47935015-48016679 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human CNGA1 associations

Human Disease Mouse Models
       Retinitis Pigmentosa 49; RP49   OMIM: 613756
Retinitis Pigmentosa; RP   OMIM: 268000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Cnga1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026745 VEGA Gene Model | MGI Sequence Detail 40580 C57BL/6J ±  kb
transcript OTTMUST00000138684 VEGA | MGI Sequence Detail 2510 Not Applicable  
polypeptide OTTMUSP00000072868 VEGA | MGI Sequence Detail 684 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    316 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000000686 cGMP-gated cation channel alpha-1
  • InterPro Domains
    IPR032945 cGMP-gated cation channel alpha-1
    IPR018488 Cyclic nucleotide-binding, conserved site
    IPR000595 Cyclic nucleotide-binding domain
    IPR018490 Cyclic nucleotide-binding-like
    IPR032406 Cyclic nucleotide-gated channel, C-terminal leucine zipper domain
    IPR005821 Ion transport domain
    IPR014710 RmlC-like jelly roll fold
Molecular
Reagents
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  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-2038
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 19
  • Earliest
    J:2297 Altherr MR, et al., Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase beta-subunit gene in mouse and human: tight linkage to the Huntington disease region (4p16.3). Genomics. 1992 Apr;12(4):750-4
  • Latest
    J:179991 Cisneros-Mejorado A, et al., cGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation. FEBS Lett. 2012 Jan 20;586(2):149-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory