Cnbp
Gene Detail

Symbol Name ID

Cnbp cellular nucleic acid binding protein MGI:88431

Synonyms

Znf9

Feature Type

protein coding gene

Genetic Map

Chromosome 6

39.13 cM, cytoband D1-D2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:87843082-87851106 bp, - strand From VEGA annotation of GRCm38   8025 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2567  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: cellular nucleic acid-binding protein
Gene Tree: Cnbp

Human homologs

Human Homolog		CNBP, CCHC-type zinc finger, nucleic acid binding protein
NCBI Gene ID		7555
neXtProt AC		NX_P62633
Human Synonyms		CNBP1, DM2, PROMM, RNF163, ZCCHC22, ZNF9
Human Chr (Location)		3q21; chr3:128886658-128902810 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CNBP

Alleles and phenotypes

All alleles(92) : Targeted(3) Gene trapped(88) Transgenic(1)
 

Mice homozygous for a retroviral insertional mutation exhibit reduced embryo size and embryonic lethality associated with anterior patterning defects and severe forebrain truncation. About 40% of heterozygotes exhibit reduced embryo size, various craniofacial defects, and neonatal death.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	positive regulation of cell proliferation, positive regulation of transcription, DNA-dependent, ...
Component	cytoplasm, cytosol, ...
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (151)    Tissues (128)    Images (13)
Theiler Stages: 15, 17, 19, 20, 21, 23, 26, 28

Assay Type	Results
RNA in situ	102
RT-PCR	49

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) Genomic(1) cDNA(33) Primer pair(3)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000023465 (Evidence)
Ensembl Gene Model	ENSMUSG00000030057 (Evidence)
Entrez Gene	12785 (Evidence)
DFCI	TC1573850, TC1575530, TC1632422, TC1778073
DoTS	DT.101195061, DT.101195066, DT.101223282, DT.55215912, DT.91318288, DT.99866349
NIA Mouse Gene Index	U027586
Consensus CDS Project	CCDS51841.1
International Mouse Knockout Project Status	Cnbp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023465	VEGA Gene Model | MGI Sequence Detail	8025	C57BL/6J
transcript	OTTMUST00000057063	VEGA | MGI Sequence Detail	1708	Not Applicable
polypeptide	OTTMUSP00000027487	VEGA | MGI Sequence Detail	177	Not Applicable

All sequences(77) RefSeq(6) UniProt(6)

Polymorphisms

SNPs(15 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001878	Zinc finger, CCHC-type
Protein Ontology	PR:000005627	cellular nucleic acid-binding protein

References

(Earliest) J:21465 Warden CH, et al., Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing. Genomics. 1994 Nov 1;24(1):14-9
(Latest) J:184831 Uchibe K, et al., Identification of novel transcription-regulating genes expressed during murine molar development. Dev Dyn. 2012 Jul;241(7):1217-26
All references(56)

Other accession IDs

MGD-MRK-2033, MGI:2141361