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Clps
Gene Detail
Symbol

Name
ID
Clps
colipase, pancreatic
MGI:88421
Feature Type
protein coding gene
Genetic Map
Chromosome 17
14.76 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr17:28558210-28560766 bp, - strand
From VEGA annotation of GRCm38

  2557 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1383  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: colipase
Gene Tree: Clps

Human
homologs
Human Homolog CLPS, colipase, pancreatic
NCBI Gene ID 1208
neXtProt AC  NX_P04118
Human Chr (Location)  6p21.31; chr6:35794982-35797344 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Gene trapped(28) Targeted(5)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in increased mortality before weaning. Surviving mutants are growth retarded and remain smaller than wild-type into adulthood with decreased body fat, impaired fat absorption, elevated cholesterol, and reduced triglycerides.
 
Interactions
Clps interacts with 18 markers (Mir24-1, Mir24-2, Mir92-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process digestion, lipid catabolic process, ...
Component extracellular region, extracellular vesicular exosome
Function enzyme activator activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (12)    Tissues (2)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 12
cDNA source data(345)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(347) cDNA(346) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024251 (Evidence)
Ensembl Gene ModelENSMUSG00000024225 (Evidence)
Entrez Gene109791 (Evidence)
UniGene21160
DFCITC1573174
DoTSDT.484955, DT.55109554
NIA Mouse Gene IndexU037609
Consensus CDS ProjectCCDS28581.1
International Mouse Knockout Project StatusClps
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024251 VEGA Gene Model | MGI Sequence Detail 2557 C57BL/6J ±  kb
transcript OTTMUST00000059355 VEGA | MGI Sequence Detail 550 Not Applicable 
polypeptide OTTMUSP00000028866 VEGA | MGI Sequence Detail 113 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001981 Colipase
InterPro IPR017915 Colipase, conserved site
InterPro IPR017914 Colipase, C-terminal
InterPro IPR017913 Colipase, N-terminal
Protein Ontology PR:000005601 colipase
References
(Earliest) J:31046 Davis RC, et al., Assignment of the human pancreatic colipase gene to chromosome 66p21.1 to pter. Genomics. 1991 May;10(1):262-5
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(46)
Other
accession IDs
MGD-MRK-2020, MGI:1913537

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory