About   Help   FAQ
Clps Gene Detail
Summary
  • Symbol
    Clps
  • Name
    colipase, pancreatic
  • Feature Type
    protein coding gene
  • IDs
    MGI:88421
    NCBI Gene: 109791
  • Gene Overview
    MyGene.info: CLPS
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:28558210-28560766 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.76 cM, cytoband B1
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88421
protein coding gene Chr17:28558210-28560766 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023444
protein coding gene Chr17:27983079-27988571 (-)
A/J MGP_AJ_G0023402
protein coding gene Chr17:27043309-27046351 (-)
AKR/J MGP_AKRJ_G0023367
protein coding gene Chr17:27256049-27258606 (-)
BALB/cJ MGP_BALBcJ_G0023407
protein coding gene Chr17:27328049-27330600 (-)
C3H/HeJ MGP_C3HHeJ_G0023168
protein coding gene Chr17:27652878-27656416 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023849
protein coding gene Chr17:29110607-29115062 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021324
protein coding gene Chr17:24409534-24411903 (-)
CAST/EiJ MGP_CASTEiJ_G0022669
protein coding gene Chr17:27619640-27621967 (-)
CBA/J MGP_CBAJ_G0023142
protein coding gene Chr17:30160097-30162615 (-)
DBA/2J MGP_DBA2J_G0023273
protein coding gene Chr17:26601861-26605150 (-)
FVB/NJ MGP_FVBNJ_G0023243
protein coding gene Chr17:26425040-26427748 (-)
LP/J MGP_LPJ_G0023351
protein coding gene Chr17:28236879-28240236 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023261
protein coding gene Chr17:29567912-29571447 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023891
protein coding gene Chr17:27690830-27694453 (-)
PWK/PhJ MGP_PWKPhJ_G0022419
protein coding gene Chr17:25419759-25422678 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022237
protein coding gene Chr17:25675122-25677478 (-)
WSB/EiJ MGP_WSBEiJ_G0022731
protein coding gene Chr17:27683246-27687526 (-)



Homology
more
  • Human Ortholog
    CLPS, colipase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CLPS, colipase
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 1208
    neXtProt AC: NX_P04118
    UniProt: P04118

  • Chr Location
    6p21.31; chr6:35794982-35797344 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased mortality before weaning. Surviving mutants are growth retarded and remain smaller than wild-type into adulthood with decreased body fat, impaired fat absorption, elevated cholesterol, and reduced triglycerides.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109791 NCBI Gene Model | MGI Sequence Detail 2557 C57BL/6J ±  kb
    transcript NM_025469 RefSeq | MGI Sequence Detail 557 Not Specified  
    polypeptide Q9CQC2 UniProt | EBI | MGI Sequence Detail 113 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 348
      cDNA 347
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2020, MGI:1913537
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:31046 Davis RC, et al., Assignment of the human pancreatic colipase gene to chromosome 66p21.1 to pter. Genomics. 1991 May;10(1):262-5
    • Latest
      J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory