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Ckb
Gene Detail
 Symbol
Name
ID
Ckb
creatine kinase, brain
MGI:88407
STS D12Mit17
Synonyms B-CK, Ck-3
Feature Type protein coding gene
Genetic Map
Chromosome 12
61.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr12:111669355-111672338 bp, - strand
From NCBI annotation of GRCm38

  2984 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: creatine kinase
Gene Tree: Ckb

Human
homologs
Human Homolog CKB, creatine kinase, brain
NCBI Gene ID 1152
neXtProt AC  NX_P12277
Human Synonyms  BCK, B-CK, CKBB, HEL-211, HEL-S-29
Human Chr (Location)  14q32; chr14:103519658-103522859 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(9) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have abnormal hippocampal morphology with enlarged mossy fiber field size and display resistance to pharmacologically induced seizures, reduced habituation and spatial learning impairments.
 
Interactions
Ckb interacts with 36 markers (Mir15a, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cellular chloride ion homeostasis, phosphorylation
Component cell, cytoplasm, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (540)    Tissues (166)    Images (54)
Theiler Stages: 19, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 529
RT-PCR 11
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(4) cDNA(19) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000001270 (Evidence)
Entrez Gene12709 (Evidence)
DFCITC1573323, TC1604385
DoTSDT.101309300, DT.101387140, DT.110921820, DT.496133
NIA Mouse Gene IndexU034374, U105169, U316446
EC2.7.3.2
Consensus CDS ProjectCCDS26183.1
International Mouse Knockout Project StatusCkb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12709 NCBI Gene Model | MGI Sequence Detail 2984 C57BL/6J ±  kb
transcript NM_021273 RefSeq | MGI Sequence Detail 1478 C57BL/6 
polypeptide Q04447 UniProt | EBI | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(1)
Polymorphisms All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022415 ATP:guanido phosphotransferase active site
InterPro IPR022414 ATP:guanido phosphotransferase, catalytic domain
InterPro IPR022413 ATP:guanido phosphotransferase, N-terminal
InterPro IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
Protein Ontology PR:000005513 creatine kinase B-type
Graphical View of Protein Domain Structure
References (Earliest) J:455 Cho M, et al., A linkage map of distal mouse chromosome 12. Mamm Genome. 1991;1(1):30-6
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(65)
Other
accession IDs
MGD-MRK-1990, MGD-MRK-1997

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory