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Chgb
Gene Detail
Symbol

Name
ID
Chgb
chromogranin B
MGI:88395
Synonyms
Scg-1, secretogranin I
Feature Type
protein coding gene
Genetic Map
Chromosome 2
64.74 cM, cytoband F-G
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr2:132781278-132795079 bp, + strand
From VEGA annotation of GRCm38

  13802 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1375  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: CHGB
Protein SuperFamily: chromogranin B precursor
Gene Tree: Chgb

Human
homologs
CHGB, chromogranin B
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1114
neXtProt AC: NX_P05060

Human Synonyms: SCG1

Human Chr (Location): 20p12.3; chr20:5911328-5925361 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced catecholamine secretion from adrenal chromaffin cells.
 
Interactions
Chgb interacts with 87 markers (Mir10a, Mir20a, Mir98, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Component extracellular region, secretory granule
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (222)    Tissues (92)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 176
RT-PCR 46
cDNA source data(62)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CHGB ; Xenbase chgb    NEW 
Molecular
reagents
All nucleic(68) Genomic(1) cDNA(65) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000015662 (Evidence)
Ensembl Gene Model ENSMUSG00000027350 (Evidence)
Entrez Gene 12653 (Evidence)
UniGene 255241
DFCI TC1572022, TC1601970
DoTS DT.488023, DT.91304456
NIA Mouse Gene Index U002508
Consensus CDS Project CCDS16777.1
International Mouse Phenotyping Consortium Status Chgb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015662 VEGA Gene Model | MGI Sequence Detail 13802 C57BL/6J ±  kb
transcript OTTMUST00000037212 VEGA | MGI Sequence Detail 2740 Not Applicable 
polypeptide OTTMUSP00000016675 VEGA | MGI Sequence Detail 677 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(6)
Polymorphisms
RFLP(6) : SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001819 Chromogranin A/B
InterPro IPR018054 Chromogranin, conserved site
InterPro IPR001990 Chromogranin/secretogranin
Protein Ontology PR:000005422 secretogranin-1
References
(Earliest) J:36350 Eiden LE, et al., A nomenclature proposal for the chromogranin/secretogranin proteins. Neuroscience. 1987 Jun;21(3):1019-21
(Latest) J:217655 Zhang F, et al., Enhancer-bound LDB1 regulates a corticotrope promoter-pausing repression program. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1380-5
All references(66)
Other
accession IDs
MGD-MRK-14309, MGD-MRK-1970

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory