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Chgb
Gene Detail
 Symbol
Name
ID
Chgb
chromogranin B
MGI:88395
Synonyms Scg-1, secretogranin I
Feature Type protein coding gene
Genetic Map
Chromosome 2
64.74 cM, cytoband F-G
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr2:132781278-132795079 bp, + strand
From VEGA annotation of GRCm38

  13802 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1375  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: chromogranin B precursor
Gene Tree: Chgb

Human
homologs
Human Homolog CHGB, chromogranin B (secretogranin 1)
NCBI Gene ID 1114
neXtProt AC  NX_P05060
Human Synonyms  SCG1
Human Chr (Location)  20p12.3; chr20:5911328-5925361 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced catecholamine secretion from adrenal chromaffin cells.
 
Interactions
Chgb interacts with 88 markers (Mir10a, Mir20a, Mir98, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Component extracellular region, secretory granule
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (222)    Tissues (92)    Images (36)
Theiler Stages: 19, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 176
RT-PCR 46
cDNA source data(62)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(68) Genomic(1) cDNA(65) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000015662 (Evidence)
Ensembl Gene ModelENSMUSG00000027350 (Evidence)
Entrez Gene12653 (Evidence)
UniGene255241
DFCITC1572022, TC1601970
DoTSDT.488023, DT.91304456
NIA Mouse Gene IndexU002508
Consensus CDS ProjectCCDS16777.1
International Mouse Knockout Project StatusChgb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015662 VEGA Gene Model | MGI Sequence Detail 13802 C57BL/6J ±  kb
transcript OTTMUST00000037212 VEGA | MGI Sequence Detail 2740 Not Applicable 
polypeptide OTTMUSP00000016675 VEGA | MGI Sequence Detail 677 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(6)
Polymorphisms RFLP(6) : SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001819 Chromogranin A/B
InterPro IPR018054 Chromogranin, conserved site
InterPro IPR001990 Chromogranin/secretogranin
Protein Ontology PR:000005422 secretogranin-1
References (Earliest) J:36350 Eiden LE, et al., A nomenclature proposal for the chromogranin/secretogranin proteins. Neuroscience. 1987 Jun;21(3):1019-21
(Latest) J:208186 Zhang K, et al., Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms. J Neurochem. 2014 Apr;129(1):48-59
All references(63)
Other
accession IDs
MGD-MRK-14309, MGD-MRK-1970

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory