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Chga Gene Detail
Summary
  • Symbol
    Chga
  • Name
    chromogranin A
  • Synonyms
    ChrA
  • Feature Type
    protein coding gene
  • IDs
    MGI:88394
    NCBI Gene: 12652
  • Gene Overview
    MyGene.info: CHGA
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:102554969-102565028 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 51.66 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88394
protein coding gene Chr12:102554941-102565028 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020033
protein coding gene Chr12:104191300-104201779 (+)
A/J MGP_AJ_G0019989
protein coding gene Chr12:100193263-100203075 (+)
AKR/J MGP_AKRJ_G0019965
protein coding gene Chr12:103037681-103047733 (+)
BALB/cJ MGP_BALBcJ_G0019975
protein coding gene Chr12:100543441-100553501 (+)
C3H/HeJ MGP_C3HHeJ_G0019777
protein coding gene Chr12:103495510-103505338 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020424
protein coding gene Chr12:107436652-107449020 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018037
protein coding gene Chr12:97206499-97217292 (+)
CAST/EiJ MGP_CASTEiJ_G0019323
protein coding gene Chr12:98334434-98345958 (+)
CBA/J MGP_CBAJ_G0019749
protein coding gene Chr12:111424494-111437517 (+)
DBA/2J MGP_DBA2J_G0019860
protein coding gene Chr12:99708539-99718373 (+)
FVB/NJ MGP_FVBNJ_G0019849
protein coding gene Chr12:98437286-98447584 (+)
LP/J MGP_LPJ_G0019936
protein coding gene Chr12:104042235-104052282 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019889
protein coding gene Chr12:114898823-114908869 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020453
protein coding gene Chr12:102534327-102545743 (+)
PWK/PhJ MGP_PWKPhJ_G0019086
protein coding gene Chr12:94265209-94275414 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018882
protein coding gene Chr12:96719026-96729800 (+)
WSB/EiJ MGP_WSBEiJ_G0019377
protein coding gene Chr12:103427097-103438063 (+)



Homology
more
  • Human Ortholog
    CHGA, chromogranin A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CHGA, chromogranin A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGA
  • Links
    NCBI Gene ID: 1113
    neXtProt AC: NX_P10645
    UniProt: P10645

  • Chr Location
    14q32.12; chr14:92922589-92935293 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes and heterozygotes for one allele display hypertension, abnormal plasma and adrenal adrenaline and noradrenaline levels and, in homozygotes, partial embryonic lethality. Homozygotes for a second allele only have elevated urinary adrenaline, noradrenaline and dopamine levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021194 Ensembl Gene Model | MGI Sequence Detail 10060 C57BL/6J ±  kb
    transcript ENSMUST00000021610 Ensembl | MGI Sequence Detail 1883 Not Applicable  
    polypeptide ENSMUSP00000021610 Ensembl | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 2
      cDNA 43
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1969
    References
    more
    • Summaries
      All 158
      Developmental Gene Expression 96
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:19363 Modi WS, et al., The human chromogranin A gene: chromosome assignment and RFLP analysis. Am J Hum Genet. 1989 Nov;45(5):814-8
    • Latest
      J:263185 Huang M, et al., Multiple roles of epithelial heparan sulfate in stomach morphogenesis. J Cell Sci. 2018 May 29;131(10)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory