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Chga
Gene Detail
Symbol

Name
ID
Chga
chromogranin A
MGI:88394
Synonyms
ChrA
Feature Type
protein coding gene
Genetic Map
Chromosome 12
51.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:102554969-102565027 bp, + strand
From NCBI annotation of GRCm38

  10059 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:976  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: chromogranin A
Gene Tree: Chga

Human
homologs
Human Homolog CHGA, chromogranin A (parathyroid secretory protein 1)
NCBI Gene ID 1113
neXtProt AC  NX_P10645
Human Synonyms  CGA
Human Chr (Location)  14q32; chr14:92923100-92935293 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes and heterozygotes for one allele display hypertension, abnormal plasma and adrenal adrenaline and noradrenaline levels and, in homozygotes, partial embryonic lethality. Homozygotes for a second allele only have elevated urinary adrenaline, noradrenaline and dopamine levels.
 
Interactions
Chga interacts with 87 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process negative regulation of neuron death, negative regulation of vasodilation, ...
Component chromaffin granule, cytoplasmic vesicle, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (174)    Tissues (75)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 114
Western blot 6
RT-PCR 46
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) Genomic(2) cDNA(42) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021194 (Evidence)
Entrez Gene12652 (Evidence)
UniGene4137
DFCITC1576224
DoTSDT.40185585
NIA Mouse Gene IndexU014305
Consensus CDS ProjectCCDS26120.1
International Mouse Knockout Project StatusChga
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12652 NCBI Gene Model | MGI Sequence Detail 10059 C57BL/6J ±  kb
transcript NM_007693 RefSeq | MGI Sequence Detail 1892 Not Specified 
polypeptide P26339 UniProt | EBI | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001819 Chromogranin A/B
InterPro IPR018054 Chromogranin, conserved site
InterPro IPR001990 Chromogranin/secretogranin
Protein Ontology PR:000005421 chromogranin-A
Graphical View of Protein Domain Structure
References
(Earliest) J:19363 Modi WS, et al., The human chromogranin A gene: chromosome assignment and RFLP analysis. Am J Hum Genet. 1989 Nov;45(5):814-8
(Latest) J:209852 Prandi S, et al., A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. PLoS One. 2013;8(12):e82820
All references(119)
Other
accession IDs
MGD-MRK-1969

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory