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Chga
Gene Detail
Symbol

Name
ID
Chga
chromogranin A
MGI:88394
Synonyms
ChrA
Feature Type
protein coding gene
Genetic Map
Chromosome 12
51.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:102554969-102565027 bp, + strand
From NCBI annotation of GRCm38

  10059 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:976  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CHGA
Protein SuperFamily: chromogranin A
Gene Tree: Chga

Human
homologs
CHGA, chromogranin A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1113
neXtProt AC: NX_P10645

Human Synonyms: CGA

Human Chr (Location): 14q32; chr14:92922589-92935293 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes and heterozygotes for one allele display hypertension, abnormal plasma and adrenal adrenaline and noradrenaline levels and, in homozygotes, partial embryonic lethality. Homozygotes for a second allele only have elevated urinary adrenaline, noradrenaline and dopamine levels.
 
Interactions
Chga interacts with 87 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (77 records)
Data Summary: Results (169)    Tissues (74)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 114
RT-PCR 46
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase chga    NEW 
Molecular
reagents
All nucleic(48) Genomic(2) cDNA(42) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021194 (Evidence)
Entrez Gene 12652 (Evidence)
UniGene 4137
DFCI TC1576224
DoTS DT.40185585
NIA Mouse Gene Index U014305
Consensus CDS Project CCDS26120.1
International Mouse Phenotyping Consortium Status Chga
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12652 NCBI Gene Model | MGI Sequence Detail 10059 C57BL/6J ±  kb
transcript NM_007693 RefSeq | MGI Sequence Detail 1892 Not Specified 
polypeptide P26339 UniProt | EBI | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001819 Chromogranin A/B
InterPro IPR018054 Chromogranin, conserved site
InterPro IPR001990 Chromogranin/secretogranin
Protein Ontology PR:000005421 chromogranin-A
Graphical View of Protein Domain Structure
References
(Earliest) J:25678 Wu HJ, et al., Structure and function of the chromogranin A gene. Clues to evolution and tissue-specific expression. J Biol Chem. 1991 Jul 15;266(20):13130-4
(Latest) J:220744 Xu EE, et al., SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models. Diabetologia. 2015 May;58(5):1013-23
All references(122)
Other
accession IDs
MGD-MRK-1969

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory