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Cga Gene Detail
Summary
  • Symbol
    Cga
  • Name
    glycoprotein hormones, alpha subunit
  • Synonyms
    aGSU, alphaGSU, alpha-GSU, alphaSU, GPHalpha, Tsha
  • Feature Type
    protein coding gene
  • IDs
    MGI:88390
    NCBI Gene: 12640
  • Gene Overview
    MyGene.info: CGA
Location & Maps
more
  • Sequence Map
    Chr4:34893779-34907370 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13592 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 16.86 cM
  • Mapping Data
    24 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    CGA, glycoprotein hormones, alpha polypeptide
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CGA, glycoprotein hormones, alpha polypeptide
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CG-ALPHA, FSHA, GPHa, GPHA1, HCG, LHA, TSHA
  • Links
    NCBI Gene ID: 1081
    neXtProt AC: NX_P01215

  • Chr Location
    6q14.3; chr6:87085498-87095147 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically and radiation induced
    1
  • Gene trapped
    11
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    1 involving Cga
  • Incidental Mutations
Homozygous null mutants exhibit male and female sterility with hypogonadism, dwarfism, hypothyroidism, and both hypertrophy and hyperplasia of pituitary thyrotropes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006474 VEGA Gene Model | MGI Sequence Detail 13592 C57BL/6J ±  kb
transcript OTTMUST00000014802 VEGA | MGI Sequence Detail 687 Not Applicable  
polypeptide OTTMUSP00000006878 VEGA | MGI Sequence Detail 120 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    153 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005388 glycoprotein hormones alpha chain
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR000476 Glycoprotein hormone alpha chain
Molecular
Reagents
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  • All nucleic 14
    Genomic 3
    cDNA 8
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-15273, MGD-MRK-1964
References
more
  • Summaries
    All 139
    Developmental Gene Expression 67
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:32632 Vamvakopoulos NC, et al., Synthesis, cloning, and identification of DNA sequences complementary to mRNAs for alpha and beta subunits of thyrotropin. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3149-53
  • Latest
    J:229902 Gaston-Massuet C, et al., Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E548-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory