About   Help   FAQ
Cga
Gene Detail
 Symbol
Name
ID
Cga
glycoprotein hormones, alpha subunit
MGI:88390
STS D4Mit41
Synonyms aGSU, alphaGSU, alpha-GSU, alphaSU, GPHalpha, Tsha
Feature Type protein coding gene
Genetic Map
Chromosome 4
16.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr4:34893779-34907370 bp, + strand
From VEGA annotation of GRCm38

  13592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:587  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glycoprotein hormones alpha chain
Gene Tree: Cga

Human
homologs
Human Homolog CGA, glycoprotein hormones, alpha polypeptide
NCBI Gene ID 1081
neXtProt AC  NX_P01215
Human Synonyms  CG-ALPHA, FSHA, GPHa, GPHA1, HCG, LHA, TSHA
Human Chr (Location)  6q12-q21; chr6:87085498-87095147 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(11) Targeted(2)
 
Homozygous null mutants exhibit male and female sterility with hypogonadism, dwarfism, hypothyroidism, and both hypertrophy and hyperplasia of pituitary thyrotropes.
 
Interactions
Cga interacts with 30 markers (Mir17, Mir20b, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cellular response to hormone stimulus, developmental growth, ...
Component cell, extracellular region
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (57 records)
Data Summary: Results (60)    Tissues (35)    Images (23)
Theiler Stages: 9, 11, 13, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 42
RT-PCR 6
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(3) cDNA(8) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006474 (Evidence)
Ensembl Gene ModelENSMUSG00000028298 (Evidence)
Entrez Gene12640 (Evidence)
DFCITC1585366, TC1589474
DoTSDT.55129657
NIA Mouse Gene IndexU004188
Consensus CDS ProjectCCDS18035.1
International Mouse Knockout Project StatusCga
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006474 VEGA Gene Model | MGI Sequence Detail 13592 C57BL/6J ±  kb
transcript OTTMUST00000014802 VEGA | MGI Sequence Detail 687 Not Applicable 
polypeptide OTTMUSP00000006878 VEGA | MGI Sequence Detail 120 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(2)
Polymorphisms RFLP(6) : SNPs within 2kb(153 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000476 Glycoprotein hormone alpha chain
Protein Ontology PR:000005388 glycoprotein hormones alpha chain
References (Earliest) J:32632 Vamvakopoulos NC, et al., Synthesis, cloning, and identification of DNA sequences complementary to mRNAs for alpha and beta subunits of thyrotropin. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3149-53
(Latest) J:201463 Watson LA, et al., Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest. 2013 May 1;123(5):2049-63
All references(130)
Other
accession IDs
MGD-MRK-15273, MGD-MRK-1964

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory