Cga
Gene Detail

Symbol Name ID

Cga glycoprotein hormones, alpha subunit MGI:88390

STS

D4Mit41

Synonyms

aGSU, alphaGSU, alpha-GSU, alphaSU, GPHalpha, Tsha

Feature Type

protein coding gene

Genetic Map

Chromosome 4

16.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr4:34893779-34907370 bp, + strand From VEGA annotation of GRCm38   13592 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:587  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glycoprotein hormones alpha chain
Gene Tree: Cga

Human homologs

Human Homolog		CGA, glycoprotein hormones, alpha polypeptide
NCBI Gene ID		1081
neXtProt AC		NX_P01215
Human Synonyms		CG-ALPHA, FSHA, GPHa, GPHA1, HCG, LHA, TSHA
Human Chr (Location)		6q12-q21; chr6:87795216-87804865 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(13) : Targeted(2) Gene trapped(11)
 

Homozygous null mutants exhibit male and female sterility with hypogonadism, dwarfism, hypothyroidism, and both hypertrophy and hyperplasia of pituitary thyrotropes.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	cellular response to hormone stimulus, developmental growth, ...
Component	extracellular region
Function	hormone activity

External Resources: FuncBase

Expression

Literature Summary: (53 records)
Data Summary: Results (56)    Tissues (35)    Images (19)
Theiler Stages: 9, 11, 13, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	42
RT-PCR	6

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(3) cDNA(8) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006474 (Evidence)
Ensembl Gene Model	ENSMUSG00000028298 (Evidence)
Entrez Gene	12640 (Evidence)
DFCI	TC1585366, TC1589474
DoTS	DT.55129657
NIA Mouse Gene Index	U004188
Consensus CDS Project	CCDS18035.1
International Mouse Knockout Project Status	Cga

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006474	VEGA Gene Model | MGI Sequence Detail	13592	C57BL/6J
transcript	OTTMUST00000014804	VEGA | MGI Sequence Detail	609	Not Applicable
polypeptide	OTTMUSP00000006880	VEGA | MGI Sequence Detail	120	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(6) : SNPs(49 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000476	Glycoprotein hormone alpha chain
Protein Ontology	PR:000005388	glycoprotein hormones alpha chain

References

(Earliest) J:32632 Vamvakopoulos NC, et al., Synthesis, cloning, and identification of DNA sequences complementary to mRNAs for alpha and beta subunits of thyrotropin. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3149-53
(Latest) J:191667 Jayakody SA, et al., SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest. 2012 Oct 1;122(10):3635-46
All references(126)

Other accession IDs

MGD-MRK-15273, MGD-MRK-1964