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Cga Gene Detail
Summary
  • Symbol
    Cga
  • Name
    glycoprotein hormones, alpha subunit
  • Synonyms
    aGSU, alphaGSU, alpha-GSU, alphaSU, GPHalpha, Tsha
  • Feature Type
    protein coding gene
  • IDs
    MGI:88390
    NCBI Gene: 12640
  • Gene Overview
    MyGene.info: CGA
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:34893779-34907370 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13592 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 16.86 cM
  • Mapping Data
    24 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    CGA, glycoprotein hormones, alpha polypeptide
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CGA, glycoprotein hormones, alpha polypeptide
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CG-ALPHA, FSHA, GPHa, GPHA1, HCG, LHA, TSHA
  • Links
    NCBI Gene ID: 1081
    neXtProt AC: NX_P01215
    UniProt: P01215

  • Chr Location
    6q14.3; chr6:87085498-87095147 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit male and female sterility with hypogonadism, dwarfism, hypothyroidism, and both hypertrophy and hyperplasia of pituitary thyrotropes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006474 VEGA Gene Model | MGI Sequence Detail 13592 C57BL/6J ±  kb
    transcript OTTMUST00000014804 VEGA | MGI Sequence Detail 609 Not Applicable  
    polypeptide OTTMUSP00000006880 VEGA | MGI Sequence Detail 120 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      153 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 3
      cDNA 9
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15273, MGD-MRK-1964
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 70
      Gene Ontology 4
      Phenotypes 18
    • Earliest
      J:32632 Vamvakopoulos NC, et al., Synthesis, cloning, and identification of DNA sequences complementary to mRNAs for alpha and beta subunits of thyrotropin. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3149-53
    • Latest
      J:255179 Haj M, et al., Mitogen- and stress-activated protein kinase 1 is required for gonadotropin-releasing hormone-mediated activation of gonadotropin alpha-subunit expression. J Biol Chem. 2017 Dec 15;292(50):20720-20731

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory