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Cga
Gene Detail
Symbol

Name
ID
Cga
glycoprotein hormones, alpha subunit
MGI:88390
STS
Synonyms
aGSU, alphaGSU, alpha-GSU, alphaSU, GPHalpha, Tsha
Feature Type
protein coding gene
Genetic Map
Chromosome 4
16.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr4:34893779-34907370 bp, + strand
From VEGA annotation of GRCm38

  13592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:587  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CGA
Protein SuperFamily: glycoprotein hormones alpha chain
Gene Tree: Cga

Human
homologs
CGA, glycoprotein hormones, alpha polypeptide
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1081
neXtProt AC: NX_P01215

Human Synonyms: CG-ALPHA, FSHA, GPHa, GPHA1, HCG, LHA, TSHA

Human Chr (Location): 6q12-q21; chr6:87085498-87095147 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(11) Targeted(3)
Incidental mutations (data from CvDC )
 
Homozygous null mutants exhibit male and female sterility with hypogonadism, dwarfism, hypothyroidism, and both hypertrophy and hyperplasia of pituitary thyrotropes.
 
Interactions
Cga interacts with 30 markers (Mir17, Mir20b, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cellular response to hormone stimulus, developmental growth, ...
Component cell, extracellular region
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (62 records)
Data Summary: Results (73)    Tissues (40)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 48
RT-PCR 6
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CGA ; Xenbase cga ; ZFIN cga    NEW 
Molecular
reagents
All nucleic(14) Genomic(3) cDNA(8) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006474 (Evidence)
Ensembl Gene Model ENSMUSG00000028298 (Evidence)
Entrez Gene 12640 (Evidence)
DFCI TC1585366, TC1589474
DoTS DT.55129657
NIA Mouse Gene Index U004188
Consensus CDS Project CCDS18035.1
International Mouse Phenotyping Consortium Status Cga
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006474 VEGA Gene Model | MGI Sequence Detail 13592 C57BL/6J ±  kb
transcript OTTMUST00000014804 VEGA | MGI Sequence Detail 609 Not Applicable 
polypeptide OTTMUSP00000006880 VEGA | MGI Sequence Detail 120 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(6) : SNPs within 2kb(153 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029034 Cystine-knot cytokine
InterPro IPR000476 Glycoprotein hormone alpha chain
Protein Ontology PR:000005388 glycoprotein hormones alpha chain
References
(Earliest) J:32632 Vamvakopoulos NC, et al., Synthesis, cloning, and identification of DNA sequences complementary to mRNAs for alpha and beta subunits of thyrotropin. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3149-53
(Latest) J:218295 Mortensen AH, et al., Deletion of OTX2 in neural ectoderm delays anterior pituitary development. Hum Mol Genet. 2015 Feb 15;24(4):939-53
All references(136)
Other
accession IDs
MGD-MRK-15273, MGD-MRK-1964

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory