F13b MGI Mouse Gene Detail - MGI:88379 - coagulation factor XIII, beta subunit

Symbol

F13b
Name

coagulation factor XIII, beta subunit
Synonyms

Cf-13b, Cf13b

Feature Type

protein coding gene
IDs

MGI:88379
NCBI Gene: 14060
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:139429440-139451490 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 61.57 cM, cytoband F
Mapping Data

3 experiments

SNPs within 2kb

716 from dbSNP Build 142
Strain Annotations

19
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88379	protein coding gene	Chr1:139429285-139451496 (+)
129S1/SvImJ	ENSMUSG00200007506	protein coding gene	Chr1:137061858-137083908 (+)
A/J	ENSMUSG00195014530	protein coding gene	Chr1:136155940-136178328 (+)
AKR/J	ENSMUSG00220002958	protein coding gene	Chr1:136015313-136037366 (+)
BALB/cJ	ENSMUSG00180011092	protein coding gene	Chr1:136659343-136681393 (+)
C3H/HeJ	ENSMUSG00175006452	protein coding gene	Chr1:136371140-136393517 (+)
C57BL/6NJ	ENSMUSG00215015679	protein coding gene	Chr1:136361431-136383481 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014669	protein coding gene	Chr1:131062012-131084557 (+)
CAST/EiJ	ENSTCUG00005013059	protein coding gene	Chr1:135278874-135300961 (+)
CBA/J	ENSMUSG00210013786	protein coding gene	Chr1:136319371-136341747 (+)
DBA/2J	ENSMUSG00185028361	protein coding gene	Chr1:140677866-140699922 (+)
FVB/NJ	ENSMUSG00205002273	protein coding gene	Chr1:135678262-135700638 (+)
JF1/MsJ	ENSUMUG00000021635	protein coding gene	Chr1:139752163-139774301 (+)
LP/J	ENSMUSG00230038835	protein coding gene	Chr1:140193482-140215535 (+)
NOD/ShiLtJ	ENSMUSG00190002164	protein coding gene	Chr1:136294167-136316226 (+)
NZO/HlLtJ	ENSMUSG00225000095	protein coding gene	Chr1:143968047-143990097 (+)
PWK/PhJ	ENSLUMG00010001800	protein coding gene	Chr1:135368514-135396943 (+)
SPRET/EiJ	ENSMSPG00010012030	protein coding gene	Chr1:138271847-138293642 (+)
WSB/EiJ	ENSIUOG00005025533	protein coding gene	Chr1:136101624-136123782 (+)

Human Ortholog

F13B, coagulation factor XIII B chain

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

F13B, coagulation factor XIII B chain
Synonyms

FXIIIB
Links

HGNC:3534

NCBI Gene ID: 2165

UniProt: P05160
Chr Location

1q31.3; chr1:197038737-197067260 (-) GRCh38

MGI Vertebrate Homology

F13b stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: F13B
Gene Tree

F13b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving F13b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available

Mice homozygous for a null mutation display increased bleeding time.

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All GO Annotations

9
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

634
Tissues

14
cDNA Data

23
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

6
UniProt

3
CCDS

CCDS48386.1

Ensembl

ENSMUSG00000026368 (Evidence)
NCBI Gene

14060

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026368	Ensembl Gene Model \| MGI Sequence Detail	22051	C57BL/6J	± kb
transcript	ENSMUST00000027615	Ensembl \| MGI Sequence Detail	2379	Not Applicable
polypeptide	ENSMUSP00000027615	Ensembl \| MGI Sequence Detail	669	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007298 coagulation factor XIII B chain

(term hierarchy)
InterPro Domains

IPR051503 Complement System Regulators and Virion Entry Mediators

IPR000436 Sushi/SCR/CCP domain

IPR035976 Sushi/SCR/CCP superfamily
GlyGen

Q07968 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 25

cDNA 23

Primer pair 2

Microarray probesets 3

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MGD-MRK-1945, MGD-MRK-1951, MGI:1309530

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:282553 Silva LM, et al., Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation. Blood. 2019 Jul 18;134(3):291-303

TSS for F13b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9177	Chr1:139429417-139429428 (+)	-17 bp
Tssr9178	Chr1:139429430-139429464 (+)	7 bp
Tssr9179	Chr1:139429472-139429484 (+)	38 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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