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Cenpb
Gene Detail
Symbol

Name
ID
Cenpb
centromere protein B
MGI:88376
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:131175182-131180067 bp, - strand
From VEGA annotation of GRCm38

  4886 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1370  Vertebrate Homology Class
1 human; 1 mouse; 1 dog

HCOP human homology predictions: CENPB
Gene Tree: Cenpb

Human
homologs
CENPB, centromere protein B, 80kDa
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1059
neXtProt AC: NX_P07199

Human Chr (Location): 20p13; chr20:3783851-3786690 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele display decreased body weight, small testis, oligospermia, and an age- and background-dependent reduction in female reproductive competence associated with abnormalities in uterus morphology, metral environment, gestational length, and parturition.
 
Interactions
Cenpb interacts with 189 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process regulation of transcription, DNA-templated
Component chromosome, chromosome, centromeric region, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (29)    Tissues (29)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
cDNA source data(137)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(146) Genomic(8) cDNA(137) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015913 (Evidence)
Ensembl Gene Model ENSMUSG00000068267 (Evidence)
Entrez Gene 12616 (Evidence)
UniGene 440169
DFCI TC1575222, TC1660823
NIA Mouse Gene Index U023378
Consensus CDS Project CCDS16757.1
International Mouse Phenotyping Consortium Status Cenpb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015913 VEGA Gene Model | MGI Sequence Detail 4886 C57BL/6J ±  kb
transcript OTTMUST00000037804 VEGA | MGI Sequence Detail 4886 Not Applicable 
polypeptide OTTMUSP00000016971 VEGA | MGI Sequence Detail 599 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015115 Centromere protein Cenp-B, dimerisation domain
InterPro IPR004875 DDE superfamily endonuclease, CENP-B-like
InterPro IPR007889 DNA binding HTH domain, Psq-type
InterPro IPR009057 Homeodomain-like
InterPro IPR006600 HTH CenpB-type DNA-binding domain
Protein Ontology PR:000005324 major centromere autoantigen B
References
(Earliest) J:16360 Sullivan KF, et al., CENP-B is a highly conserved mammalian centromere protein with homology to the helix-loop-helix family of proteins. Chromosoma. 1991 Jul;100(6):360-70
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(35)
Other
accession IDs
MGD-MRK-1940

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory