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Cel Gene Detail
Summary
  • Symbol
    Cel
  • Name
    carboxyl ester lipase
  • Synonyms
    1810036E18Rik, BAL
  • Feature Type
    protein coding gene
  • IDs
    MGI:88374
    NCBI Gene: 12613
  • Gene Overview
    MyGene.info: CEL
Location & Maps
more
  • Sequence Map
    Chr2:28555795-28563403 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7609 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    CEL, carboxyl ester lipase
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CEL, carboxyl ester lipase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BAL, BSDL, BSSL, CEase, CELL, FAP, FAPP, LIPA, MODY8
  • Links
    NCBI Gene ID: 1056

  • Chr Location
    9q34.13; chr9:133061978-133071863 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CEL associations

Human Disease Mouse Models
       Maturity-Onset Diabetes of the Young, Type 8, with Exocrine Dysfunction;   OMIM: 609812
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced cholesteryl ester absorption.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011646 VEGA Gene Model | MGI Sequence Detail 7609 C57BL/6J ±  kb
transcript OTTMUST00000027264 VEGA | MGI Sequence Detail 2063 Not Applicable  
polypeptide OTTMUSP00000012399 VEGA | MGI Sequence Detail 599 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    31 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 300
    Genomic 4
    cDNA 293
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1918, MGI:1925734
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:4122 Wen PZ, et al., Chromosomal organization of the inducible and constitutive prostaglandin synthase/cyclooxygenase genes in mouse. Genomics. 1993 Feb;15(2):458-60
  • Latest
    J:192086 Lindquist S, et al., Bile salt-stimulated lipase plays an unexpected role in arthritis development in rodents. PLoS One. 2012;7(10):e47006

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory