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Cel
Gene Detail
 Symbol
Name
ID
Cel
carboxyl ester lipase
MGI:88374
Synonyms 1810036E18Rik, BAL
Feature Type protein coding gene
Genetic Map
Chromosome 2
19.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr2:28555795-28563403 bp, - strand
From VEGA annotation of GRCm38

  7609 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37529  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 western clawed frog; 2 zebrafish

Protein SuperFamily: esterase, acetylcholinesterase type
Gene Tree: Cel

Human
homologs
Human Homolog CEL, carboxyl ester lipase
NCBI Gene ID 1056
Human Synonyms  BAL, BSDL, BSSL, CEase, CELL, FAP, FAPP, LIPA, MODY8
Human Chr (Location)  9q34.3; chr9:133061978-133071863 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CEL
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit reduced cholesteryl ester absorption.
 
Interactions
Cel interacts with 59 markers (Mir1b, Mir27b, Mir98, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process ceramide catabolic process, cholesterol catabolic process, ...
Component cytoplasm, cytosol, ...
Function acylglycerol lipase activity, carboxylic ester hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (148)    Tissues (141)    Images (10)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 102
RT-PCR 46
cDNA source data(291)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(300) Genomic(4) cDNA(293) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000011646 (Evidence)
Ensembl Gene ModelENSMUSG00000026818 (Evidence)
Entrez Gene12613 (Evidence)
UniGene236017
DFCITC1572366
DoTSDT.101187958, DT.488837
NIA Mouse Gene IndexU022449
EC3.1.1.13, 3.1.1.3
Consensus CDS ProjectCCDS15841.1
International Mouse Knockout Project StatusCel
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011646 VEGA Gene Model | MGI Sequence Detail 7609 C57BL/6J ±  kb
transcript OTTMUST00000027264 VEGA | MGI Sequence Detail 2063 Not Applicable 
polypeptide OTTMUSP00000012399 VEGA | MGI Sequence Detail 599 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(3)
Polymorphisms RFLP(4) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019826 Carboxylesterase type B, active site
InterPro IPR019819 Carboxylesterase type B, conserved site
Protein Ontology PR:000005317 bile salt-activated lipase
References (Earliest) J:4122 Wen PZ, et al., Chromosomal organization of the inducible and constitutive prostaglandin synthase/cyclooxygenase genes in mouse. Genomics. 1993 Feb;15(2):458-60
(Latest) J:192086 Lindquist S, et al., Bile salt-stimulated lipase plays an unexpected role in arthritis development in rodents. PLoS One. 2012;7(10):e47006
All references(55)
Other
accession IDs
MGD-MRK-1918, MGI:1925734

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory