Cel
Gene Detail

Symbol Name ID

Cel carboxyl ester lipase MGI:88374

Synonyms

1810036E18Rik, BAL

Feature Type

protein coding gene

Genetic Map

Chromosome 2

19.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr2:28555795-28563403 bp, - strand From VEGA annotation of GRCm38   7609 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37529  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: esterase, acetylcholinesterase type
Gene Tree: Cel

Human homologs

Human Homolog		CEL, carboxyl ester lipase
NCBI Gene ID		1056
neXtProt AC		NX_P19835
Human Synonyms		BAL, BSDL, BSSL, CEase, CELL, FAP, FAPP, LIPA, MODY8
Human Chr (Location)		9q34.3; chr9:135937365-135947248 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CEL

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a null allele exhibit reduced cholesteryl ester absorption.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	ceramide catabolic process, cholesterol catabolic process, ...
Component	cytoplasm, cytosol, ...
Function	acylglycerol lipase activity, carboxylesterase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (148)    Tissues (141)    Images (10)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	102
RT-PCR	46

cDNA source data(286)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(295) Genomic(4) cDNA(288) Primer pair(1) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000011646 (Evidence)
Ensembl Gene Model	ENSMUSG00000026818 (Evidence)
Entrez Gene	12613 (Evidence)
UniGene	236017
DFCI	TC1572366
DoTS	DT.101187958, DT.488837
NIA Mouse Gene Index	U022449
EC	3.1.1.13, 3.1.1.3
Consensus CDS Project	CCDS15841.1
International Mouse Knockout Project Status	Cel

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011646	VEGA Gene Model | MGI Sequence Detail	7609	C57BL/6J
transcript	OTTMUST00000027264	VEGA | MGI Sequence Detail	2063	Not Applicable
polypeptide	OTTMUSP00000012399	VEGA | MGI Sequence Detail	599	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(4) : SNPs(27 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002018	Carboxylesterase, type B
InterPro	IPR019826	Carboxylesterase type B, active site
InterPro	IPR019819	Carboxylesterase type B, conserved site
Protein Ontology	PR:000005317	bile salt-activated lipase

References

(Earliest) J:4122 Wen PZ, et al., Chromosomal organization of the inducible and constitutive prostaglandin synthase/cyclooxygenase genes in mouse. Genomics. 1993 Feb;15(2):458-60
(Latest) J:192086 Lindquist S, et al., Bile salt-stimulated lipase plays an unexpected role in arthritis development in rodents. PLoS One. 2012;7(10):e47006
All references(54)

Other accession IDs

MGD-MRK-1918, MGI:1925734