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Cel
Gene Detail
Symbol

Name
ID
Cel
carboxyl ester lipase
MGI:88374
Synonyms
1810036E18Rik, BAL
Feature Type
protein coding gene
Genetic Map
Chromosome 2
19.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr2:28555795-28563403 bp, - strand
From VEGA annotation of GRCm38

  7609 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37529  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 2 zebrafish

HCOP human homology predictions: CEL
Protein SuperFamily: esterase, acetylcholinesterase type
Gene Tree: Cel

Human
homologs
CEL, carboxyl ester lipase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1056

Human Synonyms: BAL, BSDL, BSSL, CEase, CELL, FAP, FAPP, LIPA, MODY8

Human Chr (Location): 9q34.3; chr9:133061978-133071863 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CEL

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit reduced cholesteryl ester absorption.
 
Interactions
Cel interacts with 58 markers (Mir1b, Mir27b, Mir98, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process ceramide catabolic process, cholesterol catabolic process, ...
Component cytoplasm, cytosol, ...
Function 1-oxa-2-oxocycloheptane lactonase activity, 3,4-dihydrocoumarin hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (148)    Tissues (141)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 102
RT-PCR 46
cDNA source data(291)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cel    NEW 
Molecular
reagents
All nucleic(300) Genomic(4) cDNA(293) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000011646 (Evidence)
Ensembl Gene Model ENSMUSG00000026818 (Evidence)
Entrez Gene 12613 (Evidence)
UniGene 236017
DFCI TC1572366
DoTS DT.101187958, DT.488837
NIA Mouse Gene Index U022449
EC 3.1.1.-, 3.1.1.13, 3.1.1.3
Consensus CDS Project CCDS15841.1
International Mouse Phenotyping Consortium Status Cel
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011646 VEGA Gene Model | MGI Sequence Detail 7609 C57BL/6J ±  kb
transcript OTTMUST00000027264 VEGA | MGI Sequence Detail 2063 Not Applicable 
polypeptide OTTMUSP00000012399 VEGA | MGI Sequence Detail 599 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(4) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019826 Carboxylesterase type B, active site
InterPro IPR019819 Carboxylesterase type B, conserved site
Protein Ontology PR:000005317 bile salt-activated lipase
References
(Earliest) J:4122 Wen PZ, et al., Chromosomal organization of the inducible and constitutive prostaglandin synthase/cyclooxygenase genes in mouse. Genomics. 1993 Feb;15(2):458-60
(Latest) J:192086 Lindquist S, et al., Bile salt-stimulated lipase plays an unexpected role in arthritis development in rodents. PLoS One. 2012;7(10):e47006
All references(54)
Other
accession IDs
MGD-MRK-1918, MGI:1925734

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory