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Cdx4 Gene Detail
Summary
  • Symbol
    Cdx4
  • Name
    caudal type homeobox 4
  • Synonyms
    Cdx3, Cdx-3, Cdx-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88362
    NCBI Gene: 12592
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:102365004-102373830 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 46.06 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88362
 protein coding gene ChrX:102365004-102374198 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035982
 protein coding gene ChrX:99952257-99961450 (+)
A/J MGP_AJ_G0035963
 protein coding gene ChrX:99887408-99909151 (+)
AKR/J MGP_AKRJ_G0035881
 protein coding gene ChrX:102907547-102916703 (+)
BALB/cJ MGP_BALBcJ_G0035953
 protein coding gene ChrX:98700762-98709955 (+)
C3H/HeJ MGP_C3HHeJ_G0035659
 protein coding gene ChrX:100425085-100434278 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036479
 protein coding gene ChrX:102926138-102935335 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033307
 protein coding gene ChrX:97541633-97550820 (+)
CAST/EiJ MGP_CASTEiJ_G0034945
 protein coding gene ChrX:84689493-84701160 (+)
CBA/J MGP_CBAJ_G0035634
 protein coding gene ChrX:106097045-106106238 (+)
DBA/2J MGP_DBA2J_G0035788
 protein coding gene ChrX:99146661-99155855 (+)
FVB/NJ MGP_FVBNJ_G0035729
 protein coding gene ChrX:98449131-98458324 (+)
LP/J MGP_LPJ_G0035881
 protein coding gene ChrX:100973928-100983121 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035761
 protein coding gene ChrX:110759536-110768729 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036505
 protein coding gene ChrX:99649530-99658740 (+)
PWK/PhJ MGP_PWKPhJ_G0034643
 protein coding gene ChrX:82279349-82288776 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034471
 protein coding gene ChrX:85392159-85401347 (+)
WSB/EiJ MGP_WSBEiJ_G0035085
 protein coding gene ChrX:98375851-98385043 (+)



Homology
more
  • Human Ortholog
    CDX4, caudal type homeobox 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDX4, caudal type homeobox 4
  • Links
    NCBI Gene ID: 1046
    neXtProt AC: NX_O14627
    UniProt: O14627

  • Chr Location
    Xq13.2; chrX:73447053-73455171 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous or female mice homozygous for a reporter/null allele exhibit defects in embryonic erythropoiesis. Male mice hemizygous for a knock-out allele display a subtle anterior transformation at the level of vertebra 15 with extremely low penetrance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    953
  • Tissues
    190
  • cDNA Data
    13
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12592 NCBI Gene Model | MGI Sequence Detail 8827 C57BL/6J ±  kb
    transcript NM_007674 RefSeq | MGI Sequence Detail 1595 ZRU/MplStud  
    polypeptide Q07424 UniProt | EBI | MGI Sequence Detail 282 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 10
      cDNA 14
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1891, MGD-MRK-1892, MGD-MRK-1895, MGD-MRK-1896
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 38
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:3682 Candia AF, et al., Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development. 1992 Dec;116(4):1123-36
    • Latest
      J:343326 Kim SE, et al., Pax3 lineage-specific deletion of Gpr161 is associated with spinal neural tube and craniofacial malformations during embryonic development. Dis Model Mech. 2023 Nov 1;16(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory