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Cdx4 Gene Detail
Summary
  • Symbol
    Cdx4
  • Name
    caudal type homeobox 4
  • Synonyms
    Cdx3, Cdx-3, Cdx-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88362
    NCBI Gene: 12592
  • Alliance
Location &
Maps
more
  • Sequence Map
    ChrX:103321398-103330224 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 46.06 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88362
protein coding gene ChrX:103321398-103330592 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035982
protein coding gene ChrX:99952257-99961450 (+)
A/J MGP_AJ_G0035963
protein coding gene ChrX:99887408-99909151 (+)
AKR/J MGP_AKRJ_G0035881
protein coding gene ChrX:102907547-102916703 (+)
BALB/cJ MGP_BALBcJ_G0035953
protein coding gene ChrX:98700762-98709955 (+)
C3H/HeJ MGP_C3HHeJ_G0035659
protein coding gene ChrX:100425085-100434278 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036479
protein coding gene ChrX:102926138-102935335 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033307
protein coding gene ChrX:97541633-97550820 (+)
CAST/EiJ MGP_CASTEiJ_G0034945
protein coding gene ChrX:84689493-84701160 (+)
CBA/J MGP_CBAJ_G0035634
protein coding gene ChrX:106097045-106106238 (+)
DBA/2J MGP_DBA2J_G0035788
protein coding gene ChrX:99146661-99155855 (+)
FVB/NJ MGP_FVBNJ_G0035729
protein coding gene ChrX:98449131-98458324 (+)
LP/J MGP_LPJ_G0035881
protein coding gene ChrX:100973928-100983121 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035761
protein coding gene ChrX:110759536-110768729 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036505
protein coding gene ChrX:99649530-99658740 (+)
PWK/PhJ MGP_PWKPhJ_G0034643
protein coding gene ChrX:82279349-82288776 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034471
protein coding gene ChrX:85392159-85401347 (+)
WSB/EiJ MGP_WSBEiJ_G0035085
protein coding gene ChrX:98375851-98385043 (+)



Homology
more
  • Human Ortholog
    CDX4, caudal type homeobox 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CDX4, caudal type homeobox 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 1046
    neXtProt AC: NX_O14627
    UniProt: O14627

  • Chr Location
    Xq13.2; chrX:73447254-73454585 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice hemizygous or female mice homozygous for a reporter/null allele exhibit defects in embryonic erythropoiesis. Male mice hemizygous for a knock-out allele display a subtle anterior transformation at the level of vertebra 15 with extremely low penetrance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12592 NCBI Gene Model | MGI Sequence Detail 8827 C57BL/6J ±  kb
transcript NM_007674 RefSeq | MGI Sequence Detail 1595 C57BL/6  
polypeptide Q07424 UniProt | EBI | MGI Sequence Detail 282 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 10
    cDNA 14
    Primer pair 2
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1891, MGD-MRK-1892, MGD-MRK-1895, MGD-MRK-1896
References
more
  • Summaries
    All 72
    Developmental Gene Expression 33
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:3682 Candia AF, et al., Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development. 1992 Dec;116(4):1123-36
  • Latest
    J:247259 Naruse C, et al., New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory