About   Help   FAQ
Cdx2
Gene Detail
Symbol

Name
ID
Cdx2
caudal type homeobox 2
MGI:88361
Synonyms
Cdx-2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
86.86 cM, cytoband G2-G3
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr5:147300805-147307270 bp, - strand
From VEGA annotation of GRCm38

  6466 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:968  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Cdx2

Human
homologs
Human Homolog CDX2, caudal type homeobox 2
NCBI Gene ID 1045
neXtProt AC  NX_Q99626
Human Synonyms  CDX2/AS, CDX3, CDX-3
Human Chr (Location)  13q12.3; chr13:27962068-27969368 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die prior to gastrulation. Heterozygotes exhibit tail abnormalities, stunted growth, defects of the vertebrae and ribs, and multiple intestinal adenomatous polyps.
 
Interactions
Cdx2 interacts with 164 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process anterior/posterior pattern specification, blastocyst development, ...
Component cell, condensed nuclear chromosome, ...
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (147 records)
Data Summary: Results (371)    Tissues (165)    Images (108)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 130
RNA in situ 53
Northern blot 5
Western blot 2
RT-PCR 176
RNase protection 5
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) Genomic(3) cDNA(19) Primer pair(10) Other(8)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000037225 (Evidence)
Ensembl Gene ModelENSMUSG00000029646 (Evidence)
Entrez Gene12591 (Evidence)
UniGene20358
DFCITC1585161
DoTSDT.487207
NIA Mouse Gene IndexU026963
Consensus CDS ProjectCCDS19878.1
International Mouse Knockout Project StatusCdx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037225 VEGA Gene Model | MGI Sequence Detail 6466 C57BL/6J ±  kb
transcript OTTMUST00000095994 VEGA | MGI Sequence Detail 2261 Not Applicable 
polypeptide OTTMUSP00000053588 VEGA | MGI Sequence Detail 311 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(5) : SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006820 Caudal-like activation domain
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000005296 homeobox protein CDX-2
References
(Earliest) J:10984 James R, et al., Homeobox gene expression in the intestinal epithelium of adult mice. J Biol Chem. 1991 Feb 15;266(5):3246-51
(Latest) J:211803 Mari L, et al., A pSMAD/CDX2 complex is essential for the intestinalization of epithelial metaplasia. Cell Rep. 2014 May 22;7(4):1197-210
All references(237)
Other
accession IDs
MGD-MRK-1890, MGD-MRK-1894

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory