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Cdx1
Gene Detail
Symbol

Name
ID
Cdx1
caudal type homeobox 1
MGI:88360
Synonyms
Cdx, Cdx-1
Feature Type
protein coding gene
Genetic Map
Chromosome 18
34.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr18:61018862-61036199 bp, - strand
From VEGA annotation of GRCm38

  17338 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1366  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CDX1
Gene Tree: Cdx1

Human
homologs
CDX1, caudal type homeobox 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1044
neXtProt AC: NX_P47902

Human Chr (Location): 5q32; chr5:150166781-150184558 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in abnormalities of the basiocciptal bone, vertebrae, and ribs.
 
Interactions
Cdx1 interacts with 122 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process anterior/posterior pattern specification, bone morphogenesis, ...
Component nucleus
Function DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (49 records)
Data Summary: Results (242)    Tissues (145)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 52
RNA in situ 93
Northern blot 22
Western blot 4
RT-PCR 66
RNase protection 5
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CDX1 ; Xenbase cdx1 ; ZFIN cdx1a, cdx1b    NEW 
Molecular
reagents
All nucleic(55) Genomic(5) cDNA(39) Primer pair(7) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037224 (Evidence)
Ensembl Gene Model ENSMUSG00000024619 (Evidence)
Entrez Gene 12590 (Evidence)
UniGene 144448
DFCI TC1584508
DoTS DT.531035
NIA Mouse Gene Index U038465
Consensus CDS Project CCDS29279.1
International Mouse Phenotyping Consortium Status Cdx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037224 VEGA Gene Model | MGI Sequence Detail 17338 C57BL/6J ±  kb
transcript OTTMUST00000095993 VEGA | MGI Sequence Detail 1750 Not Applicable 
polypeptide OTTMUSP00000053587 VEGA | MGI Sequence Detail 268 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(3) : SNPs within 2kb(135 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006820 Caudal-like activation domain
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000005295 homeobox protein CDX-1
References
(Earliest) J:9557 Duprey P, et al., A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine. Genes Dev. 1988 Dec;2(12A):1647-54
(Latest) J:219394 Boroviak T, et al., The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
All references(97)
Other
accession IDs
MGD-MRK-1888, MGD-MRK-1889, MGD-MRK-1893

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory