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Cdx1 Gene Detail
Summary
  • Symbol
    Cdx1
  • Name
    caudal type homeobox 1
  • Synonyms
    Cdx, Cdx-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88360
    NCBI Gene: 12590
  • Gene Overview
    MyGene.info: CDX1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:61018862-61036199 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 34.41 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88360
protein coding gene Chr18:61018862-61036199 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024473
protein coding gene Chr18:60873883-60892447 (-)
A/J MGP_AJ_G0024440
protein coding gene Chr18:58265093-58282469 (-)
AKR/J MGP_AKRJ_G0024410
protein coding gene Chr18:59871208-59888352 (-)
BALB/cJ MGP_BALBcJ_G0024439
protein coding gene Chr18:58391169-58408628 (-)
C3H/HeJ MGP_C3HHeJ_G0024207
protein coding gene Chr18:60097209-60114309 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024886
protein coding gene Chr18:62527893-62545027 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022317
protein coding gene Chr18:57807824-57825233 (-)
CAST/EiJ MGP_CASTEiJ_G0023680
protein coding gene Chr18:59968424-59987080 (-)
CBA/J MGP_CBAJ_G0024177
protein coding gene Chr18:64536309-64553890 (-)
DBA/2J MGP_DBA2J_G0024307
protein coding gene Chr18:57934732-57951675 (-)
FVB/NJ MGP_FVBNJ_G0024273
protein coding gene Chr18:57342862-57360593 (-)
LP/J MGP_LPJ_G0024390
protein coding gene Chr18:60721705-60739063 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024302
protein coding gene Chr18:66164041-66182307 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024933
protein coding gene Chr18:60064805-60083018 (-)
PWK/PhJ MGP_PWKPhJ_G0023423
protein coding gene Chr18:58161695-58179549 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023229
protein coding gene Chr18:60291364-60308650 (-)
WSB/EiJ MGP_WSBEiJ_G0023744
protein coding gene Chr18:59918428-59936494 (-)



Homology
more
  • Human Ortholog
    CDX1, caudal type homeobox 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CDX1, caudal type homeobox 1
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 1044
    neXtProt AC: NX_P47902
    UniProt: P47902

  • Chr Location
    5q32; chr5:150166781-150184558 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 5 alleles in 6 genetic backgrounds
    32 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in abnormalities of the basiocciptal bone, vertebrae, and ribs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12590 NCBI Gene Model | MGI Sequence Detail 17338 C57BL/6J ±  kb
    transcript NM_009880 RefSeq | MGI Sequence Detail 1750 C57BL/6  
    polypeptide P18111 UniProt | EBI | MGI Sequence Detail 268 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 5
      cDNA 40
      Primer pair 8
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1888, MGD-MRK-1889, MGD-MRK-1893
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 52
      Gene Ontology 9
      Phenotypes 27
    • Earliest
      J:9557 Duprey P, et al., A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine. Genes Dev. 1988 Dec;2(12A):1647-54
    • Latest
      J:247259 Naruse C, et al., New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory