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Cdh3
Gene Detail
Symbol

Name
ID
Cdh3
cadherin 3
MGI:88356
Synonyms
Cadp, Pcad, P-cadherin
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:106510913-106556908 bp, + strand
From Ensembl annotation of GRCm38

  45996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20425  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: cadherin
Gene Tree: Cdh3

Human
homologs
Human Homolog CDH3, cadherin 3, type 1, P-cadherin (placental)
NCBI Gene ID 1001
neXtProt AC  NX_P22223
Human Synonyms  CDHP, HJMD, PCAD
Human Chr (Location)  16q22.1; chr16:68644248-68699054 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CDH3
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(19) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in precocious development of mammary glands in virgin 10-week old females. Aged virgin females (24 weeks) exhibit alveolar hyperplasia, ductal dysplasia, and extensive lymphocyte infiltration of the mammary glands.
 
Interactions
Cdh3 interacts with 183 markers (Mir7-1, Mir16-1, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process canonical Wnt signaling pathway, cell adhesion, ...
Component cell-cell adherens junction, cytoplasm, ...
Function calcium ion binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (66 records)
Data Summary: Results (215)    Tissues (184)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 39
RNA in situ 147
Northern blot 4
Western blot 18
RT-PCR 7
cDNA source data(60)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(77) Genomic(10) cDNA(60) Primer pair(4) Other(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000061048 (Evidence)
Entrez Gene12560 (Evidence)
UniGene4658
DFCITC1577100
DoTSDT.103559969
Consensus CDS ProjectCCDS22637.1
International Mouse Knockout Project StatusCdh3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061048 Ensembl Gene Model | MGI Sequence Detail 45996 C57BL/6J ±  kb
transcript ENSMUST00000080797 Ensembl | MGI Sequence Detail 3973 Not Applicable 
polypeptide ENSMUSP00000079613 Ensembl | MGI Sequence Detail 822 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(5) : SNPs within 2kb(194 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000005245 cadherin-3
References
(Earliest) J:31206 Nose A, et al., A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos. J Cell Biol. 1986 Dec;103(6 Pt 2):2649-58
(Latest) J:206321 Veniaminova NA, et al., Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. Development. 2013 Dec;140(24):4870-80
All references(117)
Other
accession IDs
MGD-MRK-13170, MGD-MRK-1723, MGD-MRK-1883, MGI:2142516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory