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Cdh3 Gene Detail
Summary
  • Symbol
    Cdh3
  • Name
    cadherin 3
  • Synonyms
    Cadp, Pcad, P-cadherin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88356
    NCBI Gene: 12560
  • Gene Overview
    MyGene.info: CDH3
Location & Maps
more
  • Sequence Map
    Chr8:106510913-106556908 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45996 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.16 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CDH3, cadherin 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CDH3, cadherin 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDHP, HJMD, PCAD
  • Links
    NCBI Gene ID: 1001
    neXtProt AC: NX_P22223

  • Chr Location
    16q22.1; chr16:68644248-68727577 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human CDH3 associations

Human Disease Mouse Models
       Ectodermal Dysplasia, Ectrodactyly, and Macular Dystrophy Syndrome;   OMIM: 225280
Hypotrichosis, Congenital, with Juvenile Macular Dystrophy; HJMD   OMIM: 601553
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Gene trapped
    19
  • Targeted
    4
  • Incidental Mutations
Homozygous mutation of this gene results in precocious development of mammary glands in virgin 10-week old females. Aged virgin females (24 weeks) exhibit alveolar hyperplasia, ductal dysplasia, and extensive lymphocyte infiltration of the mammary glands.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061048 Ensembl Gene Model | MGI Sequence Detail 45996 C57BL/6J ±  kb
transcript ENSMUST00000080797 Ensembl | MGI Sequence Detail 3973 Not Applicable  
polypeptide ENSMUSP00000079613 Ensembl | MGI Sequence Detail 822 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    194 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 78
    Genomic 10
    cDNA 61
    Primer pair 4
    Other 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13170, MGD-MRK-1723, MGD-MRK-1883, MGI:2142516
References
more
  • Summaries
    All 123
    Developmental Gene Expression 76
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:31206 Nose A, et al., A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos. J Cell Biol. 1986 Dec;103(6 Pt 2):2649-58
  • Latest
    J:229962 Ellison D, et al., Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis. Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):E679-88

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory