About   Help   FAQ
Cdh2
Gene Detail
 Symbol
Name
ID
Cdh2
cadherin 2
MGI:88355
Synonyms Ncad, N-cadherin
Feature Type protein coding gene
Genetic Map
Chromosome 18
10.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr18:16588877-16809246 bp, - strand
From VEGA annotation of GRCm38

  220370 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cadherin
Gene Tree: Cdh2

Human
homologs
Human Homolog CDH2, cadherin 2, type 1, N-cadherin (neuronal)
NCBI Gene ID 1000
neXtProt AC  NX_P19022
Human Synonyms  CD325, CDHN, CDw325, NCAD
Human Chr (Location)  18q11.2; chr18:27950966-28177481 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in death by E10. Mutant embryos exhibit several developmental abnormalities such as growth retardation, an enlarged heart, distended pericardial sacs, abnormal heart tube, wavy neural tube, irregular somite shape, and abnormal embryo turning.
 
Interactions
Cdh2 interacts with 311 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process blood vessel morphogenesis, calcium-dependent cell-cell adhesion, ...
Component adherens junction, apical plasma membrane, ...
Function alpha-catenin binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (213 records)
Data Summary: Results (840)    Tissues (270)    Images (115)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 44
RNA in situ 764
Northern blot 4
Western blot 7
RT-PCR 21
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) Genomic(19) cDNA(25) Primer pair(6) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016310 (Evidence)
Ensembl Gene ModelENSMUSG00000024304 (Evidence)
Entrez Gene12558 (Evidence)
DFCITC1574340, TC1599170
DoTSDT.87072440, DT.94248587
NIA Mouse Gene IndexU038234, U268024
PDB1NCG, 1NCH, 1NCI, 1NCJ, 2QVI, 3Q2W, 1OP4
Consensus CDS ProjectCCDS29076.1
International Mouse Knockout Project StatusCdh2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016310 VEGA Gene Model | MGI Sequence Detail 220370 C57BL/6J ±  kb
transcript OTTMUST00000039192 VEGA | MGI Sequence Detail 4843 Not Applicable 
polypeptide OTTMUSP00000017505 VEGA | MGI Sequence Detail 906 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(4)
Polymorphisms RFLP(3) : SNPs within 2kb(1757 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR009124 Cadherin/Desmocollin
InterPro IPR015919 Cadherin-like
InterPro IPR014868 Cadherin prodomain
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000001443 cadherin-2
References (Earliest) J:14761 Miyatani S, et al., Neural cadherin: role in selective cell-cell adhesion. Science. 1989 Aug 11;245(4918):631-5
(Latest) J:207861 Manthey AL, et al., Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development. Mech Dev. 2014 Feb;131:86-110
All references(338)
Other
accession IDs
MGD-MRK-12785, MGD-MRK-1882

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory