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Cdh2 Gene Detail
Summary
  • Symbol
    Cdh2
  • Name
    cadherin 2
  • Synonyms
    Ncad, N-CAD, N-cadherin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88355
    NCBI Gene: 12558
  • Gene Overview
    MyGene.info: CDH2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:16588877-16809246 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      220370 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 10.10 cM
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    CDH2, cadherin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDH2, cadherin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD325, CDHN, CDw325, NCAD
  • Links
    NCBI Gene ID: 1000
    neXtProt AC: NX_P19022
    UniProt: P19022

  • Chr Location
    18q12.1; chr18:27932878-28177446 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20424
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CDH2
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 3 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in death by E10. Mutant embryos exhibit several developmental abnormalities such as growth retardation, an enlarged heart, distended pericardial sacs, abnormal heart tube, wavy neural tube, irregular somite shape,and abnormal embryo turning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016310 VEGA Gene Model | MGI Sequence Detail 220370 C57BL/6J ±  kb
    transcript OTTMUST00000039192 VEGA | MGI Sequence Detail 4843 Not Applicable  
    polypeptide OTTMUSP00000017505 VEGA | MGI Sequence Detail 906 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1754 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 61
      Genomic 19
      cDNA 30
      Primer pair 7
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12785, MGD-MRK-1882
    References
    more
    • Summaries
      All 484
      Developmental Gene Expression 317
      Gene Ontology 42
      Phenotypes 53
    • Earliest
      J:14761 Miyatani S, et al., Neural cadherin: role in selective cell-cell adhesion. Science. 1989 Aug 11;245(4918):631-5
    • Latest
      J:261958 Kumari P, et al., A novel non-coding RNA within an intron of CDH2 and association of its SNP with non-syndromic cleft lip and palate. Gene. 2018 Jun 5;658:123-128

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory