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Cdh2
Gene Detail
Symbol

Name
ID
Cdh2
cadherin 2
MGI:88355
Synonyms
Ncad, N-cadherin
Feature Type
protein coding gene
Genetic Map
Chromosome 18
10.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr18:16588877-16809246 bp, - strand
From VEGA annotation of GRCm38

  220370 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDH2
Protein SuperFamily: cadherin
Gene Tree: Cdh2

Human
homologs
CDH2, cadherin 2, type 1, N-cadherin (neuronal)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1000
neXtProt AC: NX_P19022

Human Synonyms: CD325, CDHN, CDw325, NCAD

Human Chr (Location): 18q11.2; chr18:27932879-28177481 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in death by E10. Mutant embryos exhibit several developmental abnormalities such as growth retardation, an enlarged heart, distended pericardial sacs, abnormal heart tube, wavy neural tube, irregular somite shape, and abnormal embryo turning.
 
Interactions
Cdh2 interacts with 310 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process blood vessel morphogenesis, brain morphogenesis, ...
Component adherens junction, apical plasma membrane, ...
Function alpha-catenin binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (245 records)
Data Summary: Results (840)    Tissues (272)    Images (115)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 44
RNA in situ 764
Northern blot 4
Western blot 7
RT-PCR 21
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CDH2 ; Xenbase cdh2 ; ZFIN cdh2    NEW 
Molecular
reagents
All nucleic(55) Genomic(19) cDNA(26) Primer pair(6) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016310 (Evidence)
Ensembl Gene Model ENSMUSG00000024304 (Evidence)
Entrez Gene 12558 (Evidence)
DFCI TC1574340, TC1599170
DoTS DT.87072440, DT.94248587
NIA Mouse Gene Index U038234, U268024
PDB 1NCG, 1NCH, 1NCI, 1NCJ, 1OP4, 2QVI, 3Q2W, 4NUM, 4NUP, 4NUQ
Consensus CDS Project CCDS29076.1
International Mouse Phenotyping Consortium Status Cdh2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016310 VEGA Gene Model | MGI Sequence Detail 220370 C57BL/6J ±  kb
transcript OTTMUST00000039192 VEGA | MGI Sequence Detail 4843 Not Applicable 
polypeptide OTTMUSP00000017505 VEGA | MGI Sequence Detail 906 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(3) : SNPs within 2kb(1757 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR014868 Cadherin prodomain
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000001443 cadherin-2
References
(Earliest) J:14761 Miyatani S, et al., Neural cadherin: role in selective cell-cell adhesion. Science. 1989 Aug 11;245(4918):631-5
(Latest) J:221812 Jiang X, et al., Specific deletion of Cdh2 in Sertoli cells leads to altered meiotic progression and subfertility of mice. Biol Reprod. 2015 Mar;92(3):79
All references(377)
Other
accession IDs
MGD-MRK-12785, MGD-MRK-1882

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory