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Cdh2 Gene Detail
Summary
  • Symbol
    Cdh2
  • Name
    cadherin 2
  • Synonyms
    Ncad, N-CAD, N-cadherin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88355
    NCBI Gene: 12558
  • Gene Overview
    MyGene.info: CDH2
Location & Maps
more
  • Sequence Map
    Chr18:16588877-16809246 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      220370 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CDH2, cadherin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDH2, cadherin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD325, CDHN, CDw325, NCAD
  • Links
    NCBI Gene ID: 1000
    neXtProt AC: NX_P19022

  • Chr Location
    18q11.2; chr18:27932879-28177481 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20424
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CDH2
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 3 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in death by E10. Mutant embryos exhibit several developmental abnormalities such as growth retardation, an enlarged heart, distended pericardial sacs, abnormal heart tube, wavy neural tube, irregular somite shape,and abnormal embryo turning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016310 VEGA Gene Model | MGI Sequence Detail 220370 C57BL/6J ±  kb
transcript OTTMUST00000039192 VEGA | MGI Sequence Detail 4843 Not Applicable  
polypeptide OTTMUSP00000017505 VEGA | MGI Sequence Detail 906 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1754 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 57
    Genomic 19
    cDNA 28
    Primer pair 6
    Other 4

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-12785, MGD-MRK-1882
References
more
  • Summaries
    All 390
    Developmental Gene Expression 257
    Gene Ontology 35
    Phenotypes 45
  • Earliest
    J:14761 Miyatani S, et al., Neural cadherin: role in selective cell-cell adhesion. Science. 1989 Aug 11;245(4918):631-5
  • Latest
    J:229121 Yamamoto H, et al., Impairment of radial glial scaffold-dependent neuronal migration and formation of double cortex by genetic ablation of afadin. Brain Res. 2015 Sep 16;1620:139-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory