Cdh2
Gene Detail

Symbol Name ID

Cdh2 cadherin 2 MGI:88355

Synonyms

Ncad, N-cadherin

Feature Type

protein coding gene

Genetic Map

Chromosome 18

10.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr18:16588877-16809246 bp, - strand From VEGA annotation of GRCm38   220370 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cadherin
Gene Tree: Cdh2

Human homologs

Human Homolog		CDH2, cadherin 2, type 1, N-cadherin (neuronal)
NCBI Gene ID		1000
neXtProt AC		NX_P19022
Human Synonyms		CD325, CDHN, CDw325, NCAD
Human Chr (Location)		18q11.2; chr18:25530930-25757445 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Homozygous mutation of this gene results in death by E10. Mutant embryos exhibit several developmental abnormalities such as growth retardation, an enlarged heart, distended pericardial sacs, abnormal heart tube, wavy neural tube, irregular somite shape, and abnormal embryo turning.

 

Gene Ontology (GO) classifications

All GO classifications: (56 annotations)

Process	blood vessel morphogenesis, calcium-dependent cell-cell adhesion, ...
Component	adherens junction, apical plasma membrane, ...
Function	alpha-catenin binding, beta-catenin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (195 records)
Data Summary: Results (812)    Tissues (245)    Images (102)
Theiler Stages: 11, 13, 15, 16, 17, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	35
RNA in situ	746
Northern blot	4
Western blot	6
RT-PCR	21

cDNA source data(147)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(179) Genomic(19) cDNA(150) Primer pair(6) Other(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016310 (Evidence)
Ensembl Gene Model	ENSMUSG00000024304 (Evidence)
Entrez Gene	12558 (Evidence)
UniGene	257437
DFCI	TC1574340, TC1599170
DoTS	DT.87072440, DT.94248587
NIA Mouse Gene Index	U038234, U268024
PDB	1NCG, 1NCH, 1NCI, 1NCJ, 2QVI, 3Q2W, 1OP4
Consensus CDS Project	CCDS29076.1
International Mouse Knockout Project Status	Cdh2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016310	VEGA Gene Model | MGI Sequence Detail	220370	C57BL/6J
transcript	OTTMUST00000039192	VEGA | MGI Sequence Detail	4843	Not Applicable
polypeptide	OTTMUSP00000017505	VEGA | MGI Sequence Detail	906	Not Applicable

All sequences(34) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(3) : SNPs(1208 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002126	Cadherin
InterPro	IPR020894	Cadherin conserved site
InterPro	IPR000233	Cadherin, cytoplasmic domain
InterPro	IPR009124	Cadherin/Desmocollin
InterPro	IPR015919	Cadherin-like
InterPro	IPR014868	Cadherin prodomain
Protein Ontology	PR:000001443	cadherin-2

References

(Earliest) J:14761 Miyatani S, et al., Neural cadherin: role in selective cell-cell adhesion. Science. 1989 Aug 11;245(4918):631-5
(Latest) J:193400 Domyan ET, et al., Roundabout receptors are critical for foregut separation from the body wall. Dev Cell. 2013 Jan 14;24(1):52-63
All references(317)

Other accession IDs

MGD-MRK-12785, MGD-MRK-1882