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Cdk1
Gene Detail
Symbol

Name
ID
Cdk1
cyclin-dependent kinase 1
MGI:88351
Synonyms
Cdc2, Cdc2a, p34CDC2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
36.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:69336635-69352938 bp, - strand
From VEGA annotation of GRCm38

  16304 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDK1
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk1

Human
homologs
CDK1, cyclin-dependent kinase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 983
neXtProt AC: NX_P06493

Human Synonyms: CDC2, CDC28A, P34CDC2

Human Chr (Location): 10q21.1; chr10:60778331-60794852 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Gene trapped(27) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die prior to E1.5.
 
Phenotype Images(3)
Interactions
Cdk1 interacts with 225 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process apoptotic process, cell aging, ...
Component centrosome, cytoplasm, ...
Function ATP binding, cyclin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (46 records)
Data Summary: Results (156)    Tissues (104)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 96
Western blot 23
RT-PCR 37
cDNA source data(139)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CDK1 ; Xenbase cdk1 ; ZFIN cdk1    NEW 
Molecular
reagents
All nucleic(146) cDNA(139) Primer pair(3) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031247 (Evidence)
Ensembl Gene Model ENSMUSG00000019942 (Evidence)
Entrez Gene 12534 (Evidence)
UniGene 281367
DFCI TC1573060
DoTS DT.536135
NIA Mouse Gene Index U031901
EC 2.7.11.22, 2.7.11.23
Consensus CDS Project CCDS23908.1
International Mouse Phenotyping Consortium Status Cdk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031247 VEGA Gene Model | MGI Sequence Detail 16304 C57BL/6J ±  kb
transcript OTTMUST00000077410 VEGA | MGI Sequence Detail 2886 Not Applicable 
polypeptide OTTMUSP00000040934 VEGA | MGI Sequence Detail 297 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003271 cell division protein kinase 1
References
(Earliest) J:19718 Arion D, et al., cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF. Cell. 1988 Oct 21;55(2):371-8
(Latest) J:216295 Garnatz AS, et al., FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development. Dev Biol. 2014 Nov 1;395(1):50-61
All references(122)
Other
accession IDs
MGD-MRK-1878

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory