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Cdk1
Gene Detail
 Symbol
Name
ID
Cdk1
cyclin-dependent kinase 1
MGI:88351
Synonyms Cdc2, Cdc2a, p34CDC2
Feature Type protein coding gene
Genetic Map
Chromosome 10
36.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:69336635-69352938 bp, - strand
From VEGA annotation of GRCm38

  16304 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk1

Human
homologs
Human Homolog CDK1, cyclin-dependent kinase 1
NCBI Gene ID 983
neXtProt AC  NX_P06493
Human Synonyms  CDC2, CDC28A, P34CDC2
Human Chr (Location)  10q21.1; chr10:60772976-60794852 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(27) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die prior to E1.5.
 
Phenotype Images(3)
Interactions
Cdk1 interacts with 225 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process apoptotic process, cell aging, ...
Component centrosome, cytoplasm, ...
Function ATP binding, cyclin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (156)    Tissues (104)    Images (26)
Theiler Stages: 1, 2, 3, 21, 22, 24, 28
Assay TypeResults
RNA in situ 96
Western blot 23
RT-PCR 37
cDNA source data(139)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(146) cDNA(139) Primer pair(3) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031247 (Evidence)
Ensembl Gene ModelENSMUSG00000019942 (Evidence)
Entrez Gene12534 (Evidence)
UniGene281367
DFCITC1573060
DoTSDT.536135
NIA Mouse Gene IndexU031901
EC2.7.11.22, 2.7.11.23
Consensus CDS ProjectCCDS23908.1
International Mouse Knockout Project StatusCdk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031247 VEGA Gene Model | MGI Sequence Detail 16304 C57BL/6J ±  kb
transcript OTTMUST00000077410 VEGA | MGI Sequence Detail 2886 Not Applicable 
polypeptide OTTMUSP00000040934 VEGA | MGI Sequence Detail 297 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(3)
Polymorphisms RFLP(3) : SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003271 cell division protein kinase 1
References (Earliest) J:19718 Arion D, et al., cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF. Cell. 1988 Oct 21;55(2):371-8
(Latest) J:205333 Otero JJ, et al., Cerebellar cortical lamination and foliation require cyclin A2. Dev Biol. 2014 Jan 15;385(2):328-39
All references(118)
Other
accession IDs
MGD-MRK-1878

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory