Cdk1
Gene Detail

Symbol Name ID

Cdk1 cyclin-dependent kinase 1 MGI:88351

Synonyms

Cdc2, Cdc2a, p34

Feature Type

protein coding gene

Genetic Map

Chromosome 10

36.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr10:69336635-69352938 bp, - strand From VEGA annotation of GRCm38   16304 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk1

Human homologs

Human Homolog		CDK1, cyclin-dependent kinase 1
NCBI Gene ID		983
neXtProt AC		NX_P06493
Human Synonyms		CDC2, CDC28A, P34CDC2
Human Chr (Location)		10q21.1; chr10:62538089-62554610 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(32) : Targeted(5) Gene trapped(27)
 

Mice homozygous for a null allele die prior to E1.5.

 

Gene Ontology (GO) classifications

All GO classifications: (51 annotations)

Process	apoptotic process, cell aging, ...
Component	cytoplasm, cytoskeleton, ...
Function	ATP binding, cyclin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (36 records)
Data Summary: Results (156)    Tissues (105)    Images (26)
Theiler Stages: 1, 2, 3, 21, 22, 24, 28

Assay Type	Results
RNA in situ	96
Western blot	23
RT-PCR	37

cDNA source data(138)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(145) cDNA(138) Primer pair(3) Other(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000031247 (Evidence)
Ensembl Gene Model	ENSMUSG00000019942 (Evidence)
Entrez Gene	12534 (Evidence)
UniGene	281367
DFCI	TC1573060
DoTS	DT.536135
NIA Mouse Gene Index	U031901
EC	2.7.11.22, 2.7.11.23
Consensus CDS Project	CCDS23908.1
International Mouse Knockout Project Status	Cdk1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031247	VEGA Gene Model | MGI Sequence Detail	16304	C57BL/6J
transcript	OTTMUST00000077410	VEGA | MGI Sequence Detail	2886	Not Applicable
polypeptide	OTTMUSP00000040934	VEGA | MGI Sequence Detail	297	Not Applicable

All sequences(42) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(3) : SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000003271	cell division protein kinase 1

References

(Earliest) J:19718 Arion D, et al., cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF. Cell. 1988 Oct 21;55(2):371-8
(Latest) J:193355 Pomerantz Y, et al., From ubiquitin-proteasomal degradation to CDK1 inactivation: requirements for the first polar body extrusion in mouse oocytes. FASEB J. 2012 Nov;26(11):4495-505
All references(112)

Other accession IDs

MGD-MRK-1878