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Cd8b1
Gene Detail
Symbol

Name
ID
Cd8b1
CD8 antigen, beta chain 1
MGI:88347
STS
Synonyms
Ly-3, Ly-C, Lyt-3
Feature Type
protein coding gene
Genetic Map
Chromosome 6
32.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(39)
Sequence Map
Chr6:71322812-71337451 bp, + strand
From NCBI annotation of GRCm38

  14640 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3621  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: CD8B
Protein SuperFamily: T-cell surface glycoprotein CD8 beta chain
Gene Tree: Cd8b1

Human
homologs
CD8B, CD8b molecule
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 926
neXtProt AC: NX_P10966

Human Synonyms: CD8B1, LEU2, LY3, LYT3, P37

Human Chr (Location): 2p12; chr2:86815337-86861924 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Spontaneous(1) Targeted(3) Transgenic(1)
Genomic Mutations involving Cd8b1 (1)
Incidental mutations (data from APF , CvDC )
 
Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens.
 
Interactions
Cd8b1 interacts with 85 markers (Mir22, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process adaptive immune response, immune system process
Component cell surface, external side of plasma membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(8) cDNA(16) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000053044 (Evidence)
Entrez Gene 12526 (Evidence)
NIA Mouse Gene Index U007017
PDB 2ATP, 3B9K, 3DMM
Consensus CDS Project CCDS39506.1
International Mouse Phenotyping Consortium Status Cd8b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12526 NCBI Gene Model | MGI Sequence Detail 14640 C57BL/6J ±  kb
transcript NM_009858 RefSeq | MGI Sequence Detail 1416 C57BL/6 
polypeptide P10300 UniProt | EBI | MGI Sequence Detail 213 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(5)
Polymorphisms
All PCR and RFLP(9) : PCR(6) RFLP(3) SNPs within 2kb(147 from dbSNP Build 137)    SNPs within 2kb including multiple locations(153)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR013106 Immunoglobulin V-set domain
Protein Ontology PR:000001085 T-cell surface glycoprotein CD8 beta chain
Graphical View of Protein Domain Structure
References
(Earliest) J:13485 Green MC, et al., Locus order in LG XVII. Mouse News Lett. 1968;39:28
(Latest) J:215038 Mott KR, et al., CD8alpha dendritic cells drive establishment of HSV-1 latency. PLoS One. 2014;9(4):e93444
All references(109)
Other
accession IDs
MGD-MRK-11970, MGD-MRK-12075, MGD-MRK-1873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory