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Cd8b1
Gene Detail
Symbol

Name
ID
Cd8b1
CD8 antigen, beta chain 1
MGI:88347
STS
Synonyms
Ly-3, Ly-C, Lyt-3
Feature Type
protein coding gene
Genetic Map
Chromosome 6
32.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(39)
Sequence Map
Chr6:71322812-71337451 bp, + strand
From NCBI annotation of GRCm38

  14640 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3621  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: T-cell surface glycoprotein CD8 beta chain
Gene Tree: Cd8b1

Human
homologs
Human Homolog CD8B, CD8b molecule
NCBI Gene ID 926
neXtProt AC  NX_P10966
Human Synonyms  CD8B1, LEU2, LY3, LYT3, P37
Human Chr (Location)  2p12; chr2:86815337-86861924 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens.
 
Interactions
Cd8b1 interacts with 85 markers (Mir22, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process immune system process
Component cell surface, external side of plasma membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(8) cDNA(16) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000053044 (Evidence)
Entrez Gene12526 (Evidence)
NIA Mouse Gene IndexU007017
PDB2ATP, 3B9K, 3DMM
Consensus CDS ProjectCCDS39506.1
International Mouse Knockout Project StatusCd8b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12526 NCBI Gene Model | MGI Sequence Detail 14640 C57BL/6J ±  kb
transcript NM_009858 RefSeq | MGI Sequence Detail 1416 C57BL/6 
polypeptide P10300 UniProt | EBI | MGI Sequence Detail 213 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(9)
Polymorphisms
All PCR and RFLP(9) : PCR(6) RFLP(3) SNPs within 2kb(147 from dbSNP Build 137)    SNPs within 2kb including multiple locations(153)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003596 Immunoglobulin V-set, subgroup
Protein Ontology PR:000001085 T-cell surface glycoprotein CD8 beta chain
Graphical View of Protein Domain Structure
References
(Earliest) J:13485 Green MC, et al., Locus order in LG XVII. Mouse News Lett. 1968;39:28
(Latest) J:214403 Matundan H, et al., Role of CD8+ T cells and lymphoid dendritic cells in protection from ocular herpes simplex virus 1 challenge in immunized mice. J Virol. 2014 Jul;88(14):8016-27
All references(112)
Other
accession IDs
MGD-MRK-11970, MGD-MRK-12075, MGD-MRK-1873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory