Cd8b1 MGI Mouse Gene Detail - MGI:88347

Symbol

Cd8b1
Name

CD8 subunit beta 1
Synonyms

Ly-3, Ly-C, Lyt-3

Feature Type

protein coding gene
IDs

MGI:88347
NCBI Gene: 12526
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr6:71299772-71314476 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 32.14 cM
Mapping Data

39 experiments

SNPs within 2kb

145 from dbSNP Build 142
Strain Annotations

18
PCR

6
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88347	protein coding gene	Chr6:71299772-71314478 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030856	protein coding gene	Chr6:71792258-71809204 (+)
A/J	MGP_AJ_G0030826	protein coding gene	Chr6:69031964-69048274 (+)
AKR/J	MGP_AKRJ_G0030755	protein coding gene	Chr6:71014415-71030684 (+)
BALB/cJ	MGP_BALBcJ_G0030837	protein coding gene	Chr6:69065879-69080953 (+)
C3H/HeJ	MGP_C3HHeJ_G0030875	protein coding gene	Chr6:113217413-113233081 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031295	protein coding gene	Chr6:73686459-73703065 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028484	protein coding gene	Chr6:68215700-68230255 (+)
CAST/EiJ	MGP_CASTEiJ_G0029945	protein coding gene	Chr6:70875116-70890976 (+)
CBA/J	MGP_CBAJ_G0030524	protein coding gene	Chr6:76609243-76623949 (+)
DBA/2J	MGP_DBA2J_G0030676	protein coding gene	Chr6:68405167-68419863 (+)
FVB/NJ	MGP_FVBNJ_G0030629	protein coding gene	Chr6:67776472-67791169 (+)
LP/J	MGP_LPJ_G0030755	protein coding gene	Chr6:71721342-71736046 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030664	protein coding gene	Chr6:80104418-80119046 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031321	protein coding gene	Chr6:70859562-70877102 (+)
PWK/PhJ	MGP_PWKPhJ_G0029661	protein coding gene	Chr6:67281006-67292634 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029489	protein coding gene	Chr6:69568304-69582629 (+)
WSB/EiJ	MGP_WSBEiJ_G0030027	protein coding gene	Chr6:71200665-71215344 (+)

Human Ortholog

CD8B, CD8 subunit beta

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD8B, CD8 subunit beta
Synonyms

CD8B1, CD8beta, LEU2, Ly-3, LY3, LYT3, P37
Links

HGNC:1707

NCBI Gene ID: 926

neXtProt AC: NX_P10966

UniProt: P10966
Chr Location

2p11.2; chr2:86815339-86861924 (-) GRCh38

Human Ortholog

CD8B2, CD8B family member 2
Synonyms

CD8BP
Links

HGNC:1708

NCBI Gene ID: 927

UniProt: A6NJW9
Chr Location

2q12.2; chr2:106487364-106544297 (+) GRCh38

MGI Vertebrate Homology

Cd8b1 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CD8B, CD8B2
Gene Tree

Cd8b1

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Phenotype Summary

16 phenotypes from 5 alleles in 5 genetic backgrounds
8 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

2
Endonuclease-mediated

3
Spontaneous

1
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Cd8b1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens.

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All GO Annotations

12
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

46
cDNA Data

17
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

2
UniProt

5
CCDS

CCDS39506.1

Ensembl

ENSMUSG00000053044 (Evidence)
NCBI Gene

12526

			Length	Strain/Species	Flank
genomic	12526	NCBI Gene Model \| MGI Sequence Detail	14705	C57BL/6J	± kb
transcript	NM_009858	RefSeq \| MGI Sequence Detail	1481	ZRU/MplStud
polypeptide	P10300	UniProt \| EBI \| MGI Sequence Detail	213	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001085 T-cell surface glycoprotein CD8 beta chain

(term hierarchy)
PDB

2ATP, 3B9K, 3DMM
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain

IPR042414 T-cell surface glycoprotein CD8 beta chain

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All nucleic 29

Genomic 8

cDNA 18

Primer pair 3

Microarray probesets 5

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MGD-MRK-11970, MGD-MRK-12075, MGD-MRK-1873

Summaries

All 136

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 21
Earliest

J:5214 Boyse EA, et al., Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes. Transplantation. 1971 Mar;11(3):351-3
Latest

J:331514 Shinzawa M, et al., Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus. Nat Immunol. 2022 May;23(5):731-742

TSS for Cd8b1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56995	Chr6:71299738-71299749 (+)	-28 bp
Tssr56996	Chr6:71299759-71299828 (+)	22 bp
Tssr1881	Chr6:71302410-71302420 (+)	2,643 bp
Tssr56997	Chr6:71302438-71302447 (+)	2,671 bp
Tssr56998	Chr6:71302483-71302503 (+)	2,721 bp
Tssr56999	Chr6:71302821-71302826 (+)	3,052 bp
Tssr57000	Chr6:71302983-71303001 (+)	3,220 bp
Tssr57001	Chr6:71306238-71306249 (+)	6,472 bp
Tssr57002	Chr6:71306738-71306759 (+)	6,977 bp
Tssr57003	Chr6:71311092-71311105 (+)	11,327 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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