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Cd72
Gene Detail
Symbol

Name
ID
Cd72
CD72 antigen
MGI:88345
Synonyms
Ly-19, Ly-32, Lyb-2, Ly-m19
Feature Type
protein coding gene
Genetic Map
Chromosome 4
23.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(40)
Sequence Map
Chr4:43446462-43454628 bp, - strand
From VEGA annotation of GRCm38

  8167 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1350  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CD72
Gene Tree: Cd72

Human
homologs
CD72, CD72 molecule
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 971
neXtProt AC: NX_P21854

Human Synonyms: CD72b, LYB2

Human Chr (Location): 9p13.3; chr9:35609979-35646857 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in impaired B cell development and delayed maturation, resulting in reduced numbers of mature B cells and an expansion of pre-B cells. Mice have fewer peripheral mature B-2 cells and more B-1 cells. B cells are hyperproliferative in response to stimuli.
 
Interactions
Cd72 interacts with 131 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component integral component of membrane, integral component of plasma membrane, ...
Function carbohydrate binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006823 (Evidence)
Ensembl Gene Model ENSMUSG00000028459 (Evidence)
Entrez Gene 12517 (Evidence)
NIA Mouse Gene Index U024986
Consensus CDS Project CCDS38740.1, CCDS51164.1, CCDS51165.1, CCDS51166.1
International Mouse Phenotyping Consortium Status Cd72
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006823 VEGA Gene Model | MGI Sequence Detail 8167 C57BL/6J ±  kb
transcript OTTMUST00000015747 VEGA | MGI Sequence Detail 1505 Not Applicable 
polypeptide OTTMUSP00000007234 VEGA | MGI Sequence Detail 361 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(22) UniProt(8)
Polymorphisms
RFLP(1) : SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000001287 CD72 molecule
References
(Earliest) J:12065 Sato H, et al., A new alloantigen expressed on B cells: the Lyb-2 system. Immunogenetics. 1976;3:565-572
(Latest) J:204782 Xu M, et al., Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease. J Immunol. 2013 Jun 1;190(11):5436-45
All references(71)
Other
accession IDs
MGD-MRK-11957, MGD-MRK-11973, MGD-MRK-12012, MGD-MRK-12054, MGD-MRK-1871

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory