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Cd72 Gene Detail
Summary
  • Symbol
    Cd72
  • Name
    CD72 antigen
  • Synonyms
    Ly-19, Ly-32, Lyb-2, Ly-m19
  • Feature Type
    protein coding gene
  • IDs
    MGI:88345
    NCBI Gene: 12517
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43447724-43455102 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 23.04 cM
  • Mapping Data
    40 experiments
Strain
Comparison
more
  • SNPs within 2kb
    235 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88345
protein coding gene Chr4:43446462-43454741 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028206
protein coding gene Chr4:41557608-41565762 (-)
A/J MGP_AJ_G0028162
protein coding gene Chr4:40084894-40093050 (-)
AKR/J MGP_AKRJ_G0028114
protein coding gene Chr4:40996639-41004962 (-)
BALB/cJ MGP_BALBcJ_G0028182
protein coding gene Chr4:40174600-40182756 (-)
C3H/HeJ MGP_C3HHeJ_G0027904
protein coding gene Chr4:41621687-41629843 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028623
protein coding gene Chr4:43118629-43126795 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025935
protein coding gene Chr4:37536014-37544358 (-)
CAST/EiJ MGP_CASTEiJ_G0027344
protein coding gene Chr4:41126182-41134437 (-)
CBA/J MGP_CBAJ_G0027870
protein coding gene Chr4:44423316-44431473 (-)
DBA/2J MGP_DBA2J_G0028019
protein coding gene Chr4:39996890-40005047 (-)
FVB/NJ MGP_FVBNJ_G0027986
protein coding gene Chr4:39215090-39223521 (-)
LP/J MGP_LPJ_G0028118
protein coding gene Chr4:41614475-41622641 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028010
protein coding gene Chr4:47687931-47696254 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028659
protein coding gene Chr4:41189712-41197878 (-)
PWK/PhJ MGP_PWKPhJ_G0027070
protein coding gene Chr4:40039410-40047594 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026896
protein coding gene Chr4:40755810-40763991 (-)
WSB/EiJ MGP_WSBEiJ_G0027424
protein coding gene Chr4:41094367-41102505 (-)



Homology
more
  • Human Ortholog
    CD72, CD72 molecule
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CD72, CD72 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD72b, LYB2
  • Links
    NCBI Gene ID: 971
    neXtProt AC: NX_P21854
    UniProt: P21854

  • Chr Location
    9p13.3; chr9:35609977-35646857 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 3 genetic backgrounds
    26 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired B cell development and delayed maturation, resulting in reduced numbers of mature B cells and an expansion of pre-B cells. Mice have fewer peripheral mature B-2 cells and more B-1 cells. B cells are hyperproliferative in response to stimuli.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12517 NCBI Gene Model | MGI Sequence Detail 7379 C57BL/6J ±  kb
    transcript NM_001110320 RefSeq | MGI Sequence Detail 1503 C57BL/6  
    polypeptide P21855 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11957, MGD-MRK-11973, MGD-MRK-12012, MGD-MRK-12054, MGD-MRK-1871
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:12065 Sato H, et al., A new alloantigen expressed on B cells: the Lyb-2 system. Immunogenetics. 1976;3:565-572
    • Latest
      J:237518 Akatsu C, et al., CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP. J Exp Med. 2016 Nov 14;213(12):2691-2706

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    11/12/2019
    MGI 6.14
    The Jackson Laboratory