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Cd68 Gene Detail
Summary
  • Symbol
    Cd68
  • Name
    CD68 antigen
  • Synonyms
    gp110, Lamp4, macrosialin, Scard1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88342
    NCBI Gene: 12514
  • Alliance
    genome feature page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69555039-69556979 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    14
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88342
 protein coding gene Chr11:69555039-69556996 (-)
129S1/SvImJ ENSMUSG00200042407
 protein coding gene Chr11:66501090-66503030 (-)
A/J ENSMUSG00195035351
 protein coding gene Chr11:66527839-66529779 (-)
AKR/J ENSMUSG00220041271
 protein coding gene Chr11:66636273-66638213 (-)
BALB/cJ ENSMUSG00180043344
 protein coding gene Chr11:66597741-66599681 (-)
C3H/HeJ ENSMUSG00175054348
 protein coding gene Chr11:66547976-66549916 (-)
C57BL/6NJ ENSMUSG00215052704
 protein coding gene Chr11:66324370-66326310 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016581
 protein coding gene Chr11:64399701-64401633 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210054237
 protein coding gene Chr11:66402061-66404001 (-)
DBA/2J ENSMUSG00185055298
 protein coding gene Chr11:66601108-66603048 (-)
FVB/NJ ENSMUSG00205053516
 protein coding gene Chr11:66493365-66495305 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230052127
 protein coding gene Chr11:67711449-67713389 (-)
NOD/ShiLtJ ENSMUSG00190053188
 protein coding gene Chr11:66630966-66632906 (-)
NZO/HlLtJ ENSMUSG00225047265
 protein coding gene Chr11:69893299-69895239 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CD68, CD68 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD68, CD68 molecule
  • Synonyms
    GP110, LAMP4, SCARD1
  • Links
    NCBI Gene ID: 968
    UniProt: P34810

  • Chr Location
    17p13.1; chr17:7579380-7582112 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enhanced antigen presenting activity in dendritic cells in response to ovalbumin stimulation. Mice homozygous for another knock-out allele exhibit increased bone and dysfunctional osteoclasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    678
  • Tissues
    35
  • cDNA Data
    33
  • Literature Summary
    84
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018774 Ensembl Gene Model | MGI Sequence Detail 1941 C57BL/6J ±  kb
    transcript ENSMUST00000108654 Ensembl | MGI Sequence Detail 1008 Not Applicable  
    polypeptide ENSMUSP00000104294 Ensembl | MGI Sequence Detail 335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000002064 macrosialin
      (term hierarchy)
    • InterPro Domains
      IPR002000 Lysosome-associated membrane glycoprotein
      IPR048528 Lysosome-associated membrane glycoprotein 2-like, luminal domains
      IPR018134 Lysosome-associated membrane glycoprotein, conserved site
    • GlyGen
      P31996 10 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 2
      cDNA 33
      Primer pair 2
      Antibodies 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1868
    References
    more
    • Summaries
      All 214
      Developmental Gene Expression 84
      Gene Ontology 9
      Phenotypes 30
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:390322 Wu ML, et al., Plasmin and sterile inflammation jointly drive fatal embryonic liver degeneration in endothelial chromatin remodeler mutant mice. Development. 2026 Aug 15;153(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory