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Cd68
Gene Detail
Symbol

Name
ID
Cd68
CD68 antigen
MGI:88342
Synonyms
gp110, Lamp4, macrosialin, Scard1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:69664213-69666153 bp, - strand
From VEGA annotation of GRCm38

  1941 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:955  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: lysosome-associated membrane protein
Gene Tree: Cd68

Human
homologs
Human Homolog CD68, CD68 molecule
NCBI Gene ID 968
neXtProt AC  NX_P34810
Human Synonyms  GP110, LAMP4, SCARD1
Human Chr (Location)  17p13; chr17:7579487-7582111 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(4) Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit enhanced antigen presenting activity in dendritic cells in response to ovalbumin stimulation. Mice homozygous for another knock-out allele exhibit increased bone and dysfunctional osteoclasts.
 
Phenotype Images(3)
Interactions
Cd68 interacts with 29 markers (Mir143, Mir216b, Mir300, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cellular response to organic substance
Component endosome, integral component of membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (36)    Tissues (8)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 25
RT-PCR 8
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(2) cDNA(32) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006002 (Evidence)
Ensembl Gene ModelENSMUSG00000018774 (Evidence)
Entrez Gene12514 (Evidence)
UniGene15819
DFCITC1576477, TC1681748
DoTSDT.531185, DT.94183940, DT.99860365
NIA Mouse Gene IndexU032973
Consensus CDS ProjectCCDS36195.1, CCDS70216.1
International Mouse Knockout Project StatusCd68
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006002 VEGA Gene Model | MGI Sequence Detail 1941 C57BL/6J ±  kb
transcript OTTMUST00000013438 VEGA | MGI Sequence Detail 1230 Not Applicable 
polypeptide OTTMUSP00000006223 VEGA | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(5) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002000 Lysosome-associated membrane glycoprotein
InterPro IPR018134 Lysosome-associated membrane glycoprotein, conserved site
Protein Ontology PR:000002064 macrosialin
References
(Earliest) J:4745 Holness CL, et al., Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family. J Biol Chem. 1993 May 5;268(13):9661-6
(Latest) J:211622 DeFalco T, et al., Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2384-93
All references(62)
Other
accession IDs
MGD-MRK-1868

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory