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Cd5
Gene Detail
Symbol

Name
ID
Cd5
CD5 antigen
MGI:88340
Synonyms
Ly-1, Ly-12, Ly-A, Lyt-1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
7.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(62)
Sequence Map
Chr19:10718143-10738974 bp, - strand
From Ensembl annotation of GRCm38

  20832 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7260  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: CD5
Protein SuperFamily: T-cell surface glycoprotein CD5
Gene Tree: Cd5

Human
homologs
CD5, CD5 molecule
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 921
neXtProt AC: NX_P06127

Human Synonyms: LEU1, T1

Human Chr (Location): 11q13; chr11:61102458-61127852 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene does not result in a phenotype.
 
Interactions
Cd5 interacts with 77 markers (Mir17, Mir20b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process apoptotic signaling pathway, T cell costimulation
Component external side of plasma membrane, integral component of membrane, ...
Function glycoprotein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(2) cDNA(18) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024669 (Evidence)
Entrez Gene 12507 (Evidence)
UniGene 779
DFCI TC1582750
DoTS DT.97392241
NIA Mouse Gene Index U038810
Consensus CDS Project CCDS29586.1
International Mouse Phenotyping Consortium Status Cd5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024669 Ensembl Gene Model | MGI Sequence Detail 20832 C57BL/6J ±  kb
transcript ENSMUST00000025571 Ensembl | MGI Sequence Detail 2069 Not Applicable 
polypeptide ENSMUSP00000025571 Ensembl | MGI Sequence Detail 494 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(4) : SNPs within 2kb(236 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001190 Speract/scavenger receptor
InterPro IPR017448 Speract/scavenger receptor-related
InterPro IPR003566 T-cell surface glycoprotein CD5
Protein Ontology PR:000001839 T-cell surface glycoprotein CD5
References
(Earliest) J:5195 Itakura K, et al., Linkage groups of the theta and Ly-A loci. Nat New Biol. 1971 Mar 24;230(12):126
(Latest) J:209281 McGuire DJ, et al., CD5 enhances Th17-cell differentiation by regulating IFN-gamma response and RORgammat localization. Eur J Immunol. 2014 Apr;44(4):1137-42
All references(129)
Other
accession IDs
MGD-MRK-11947, MGD-MRK-11950, MGD-MRK-12073, MGD-MRK-1866

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory