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Cd48
Gene Detail
 Symbol
Name
ID
Cd48
CD48 antigen
MGI:88339
Synonyms Bcm-1, BCM1, BLAST-1, Sgp-60
Feature Type protein coding gene
Genetic Map
Chromosome 1
79.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr1:171682009-171705258 bp, + strand
From VEGA annotation of GRCm38

  23250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1347  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: B-cell surface glycoprotein blast-1
Gene Tree: Cd48

Human
homologs
Human Homolog CD48, CD48 molecule
NCBI Gene ID 962
neXtProt AC  NX_P09326
Human Synonyms  BCM1, BLAST, BLAST1, hCD48, mCD48, MEM-102, SLAMF2
Human Chr (Location)  1q21.3-q22; chr1:160678746-160711851 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in a slight increase in CD4+CD8- thymocytes and impaired T cell proliferation in response to mitogens, anti-CD3 antibodies, and alloantigens.
 
Interactions
Cd48 interacts with 61 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process mast cell activation, signal transduction, ...
Component anchored component of membrane, anchored component of plasma membrane, ...
Function antigen binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (52)    Tissues (4)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 52
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) Genomic(17) cDNA(48) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016904 (Evidence)
Ensembl Gene ModelENSMUSG00000015355 (Evidence)
Entrez Gene12506 (Evidence)
UniGene1738
DFCITC1577876, TC1594850
DoTSDT.491780, DT.94181119
NIA Mouse Gene IndexU001094
PDB2PTT, 2PTV
Consensus CDS ProjectCCDS15501.1
International Mouse Knockout Project StatusCd48
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016904 VEGA Gene Model | MGI Sequence Detail 23250 C57BL/6J ±  kb
transcript OTTMUST00000041023 VEGA | MGI Sequence Detail 922 Not Applicable 
polypeptide OTTMUSP00000018370 VEGA | MGI Sequence Detail 151 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(6)
Polymorphisms RFLP(2) : SNPs within 2kb(174 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR015631 Signalling lymphocyte activation molecule family receptors
Protein Ontology PR:000001308 CD48 molecule
References (Earliest) J:10552 Wong YW, et al., Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3. J Exp Med. 1990 Jun 1;171(6):2115-30
(Latest) J:174888 Boles NC, et al., CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation. Blood. 2011 Jul 7;118(1):80-7
All references(61)
Other
accession IDs
MGD-MRK-1529, MGD-MRK-1865, MGI:2138248, MGI:2138623

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory