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Cd247
Gene Detail
 Symbol
Name
ID
Cd247
CD247 antigen
MGI:88334
Synonyms 4930549J05Rik, CD3-eta, Cd3h, Cd3z, CD3zeta, CD3 zeta, CD3-zeta, CD3-zeta/eta, T3z, TCRk, Tcrz
Feature Type protein coding gene
Genetic Map
Chromosome 1
73.14 cM, cytoband G-H
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr1:165788681-165877277 bp, + strand
From VEGA annotation of GRCm38

  88597 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12818  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: CD3, zeta type
Gene Tree: Cd247

Human
homologs
Human Homolog CD247, CD247 molecule
NCBI Gene ID 919
neXtProt AC  NX_P20963
Human Synonyms  CD3H, CD3Q, CD3Z, CD3-ZETA, IMD25, T3Z, TCRZ
Human Chr (Location)  1q24.2; chr1:167430640-167518610 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD247
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) Targeted(11)
Incidental mutations (data from Mutagenetix )
 
Homozygotes for targeted null mutations exhibit greatly reduced numbers of CD4+CD8+ cells, and near absence of CD4+CD8-, CD4-CD8+ cells, and TCR expression in the thymus, but the presence of single positive T cells in lymph nodes.
 
Interactions
Cd247 interacts with 273 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell surface receptor signaling pathway, T cell receptor signaling pathway
Component alpha-beta T cell receptor complex, cytoplasm, ...
Function identical protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (74)    Tissues (67)    Images (9)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 28
RT-PCR 46
cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) Genomic(6) cDNA(24) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000034863 (Evidence)
Ensembl Gene ModelENSMUSG00000005763 (Evidence)
Entrez Gene12503 (Evidence)
DFCITC1583533, TC1591240, TC1592328, TC1601133, TC1601457, TC1615991
NIA Mouse Gene IndexU001038
Consensus CDS ProjectCCDS15443.1, CCDS48427.1, CCDS48428.2, CCDS48429.1
International Mouse Knockout Project StatusCd247
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034863 VEGA Gene Model | MGI Sequence Detail 88597 C57BL/6J ±  kb
transcript OTTMUST00000088614 VEGA | MGI Sequence Detail 1317 Not Applicable 
polypeptide OTTMUSP00000048311 VEGA | MGI Sequence Detail 206 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(16) UniProt(5)
Polymorphisms RFLP(7) : SNPs within 2kb(962 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003110 Phosphorylated immunoreceptor signaling ITAM
InterPro IPR024128 T-cell surface glycoprotein CD3 zeta/eta subunit
InterPro IPR021663 T-cell surface glycoprotein CD3 zeta/eta subunit/High affinity IgE receptor gamma subunit
Protein Ontology PR:000001027 CD247
References (Earliest) J:9058 Weissman AM, et al., Molecular cloning of the zeta chain of the T cell antigen receptor. Science. 1988 Feb 26;239(4843):1018-21
(Latest) J:209007 Klieger Y, et al., Unique zeta-chain motifs mediate a direct TCR-actin linkage critical for immunological synapse formation and T-cell activation. Eur J Immunol. 2014 Jan;44(1):58-68
All references(140)
Other
accession IDs
MGD-MRK-14699, MGD-MRK-14930, MGD-MRK-1855, MGD-MRK-1856, MGD-MRK-1857, MGI:1922598, MGI:2138612

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory