Cd247
Gene Detail

Symbol Name ID

Cd247 CD247 antigen MGI:88334

Synonyms

4930549J05Rik, CD3-eta, Cd3h, Cd3z, CD3zeta, CD3 zeta, CD3-zeta, CD3-zeta/eta, T3z, TCRk, Tcrz

Feature Type

protein coding gene

Genetic Map

Chromosome 1

73.14 cM, cytoband G-H
Detailed Genetic Map ± 1 cM


Mapping data(16)

Sequence Map

Chr1:165788681-165877276 bp, + strand From VEGA annotation of GRCm38   88596 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12818  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken

Protein SuperFamily: CD3, zeta type
Gene Tree: Cd247

Human homologs

Human Homolog		CD247, CD247 molecule
NCBI Gene ID		919
neXtProt AC		NX_P20963
Human Synonyms		CD3H, CD3Q, CD3Z, CD3-ZETA, T3Z, TCRZ
Human Chr (Location)		1q24.2; chr1:167399877-167487847 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CD247

Alleles and phenotypes

All alleles(12) : Targeted(11) Chemically induced(1)
 

Homozygotes for targeted null mutations exhibit greatly reduced numbers of CD4+CD8+ cells, and near absence of CD4+CD8-, CD4-CD8+ cells, and TCR expression in the thymus, but the presence of single positive T cells in lymph nodes.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cell surface receptor signaling pathway, signal transduction, ...
Component	alpha-beta T cell receptor complex, cytoplasm, ...
Function	identical protein binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (74)    Tissues (67)    Images (9)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	28
RT-PCR	46

cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(6) cDNA(24) Primer pair(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000034863 (Evidence)
Ensembl Gene Model	ENSMUSG00000005763 (Evidence)
Entrez Gene	12503 (Evidence)
DFCI	TC1583533, TC1591240, TC1592328, TC1601133, TC1601457, TC1615991
NIA Mouse Gene Index	U001038
Consensus CDS Project	CCDS15443.1, CCDS48427.1, CCDS48428.2, CCDS48429.1
International Mouse Knockout Project Status	Cd247

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034863	VEGA Gene Model | MGI Sequence Detail	88596	C57BL/6J
transcript	OTTMUST00000088614	VEGA | MGI Sequence Detail	1317	Not Applicable
polypeptide	OTTMUSP00000048311	VEGA | MGI Sequence Detail	206	Not Applicable

All sequences(71) RefSeq(10) UniProt(5)

Polymorphisms

RFLP(7) : SNPs(623 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003110	Phosphorylated immunoreceptor signaling ITAM
InterPro	IPR024128	T-cell surface glycoprotein CD3 zeta/eta subunit
InterPro	IPR021663	T-cell surface glycoprotein CD3 zeta/eta subunit/High affinity IgE receptor gamma subunit
Protein Ontology	PR:000001027	CD247

References

(Earliest) J:9058 Weissman AM, et al., Molecular cloning of the zeta chain of the T cell antigen receptor. Science. 1988 Feb 26;239(4843):1018-21
(Latest) J:193617 Guy CS, et al., Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat Immunol. 2013 Mar;14(3):262-70
All references(136)

Other accession IDs

MGD-MRK-14699, MGD-MRK-14930, MGD-MRK-1855, MGD-MRK-1856, MGD-MRK-1857, MGI:1922598, MGI:2138612