Cd3g
Gene Detail

Symbol Name ID

Cd3g CD3 antigen, gamma polypeptide MGI:88333

Synonyms

Ctg3, Ctg-3, T3g

Feature Type

protein coding gene

Genetic Map

Chromosome 9

24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr9:44969572-44980431 bp, - strand From VEGA annotation of GRCm38   10860 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: T-cell surface glycoprotein CD3 delta chain
Gene Tree: Cd3g

Human homologs

Human Homolog		CD3G, CD3g molecule, gamma (CD3-TCR complex)
NCBI Gene ID		917
neXtProt AC		NX_P09693
Human Synonyms		CD3-GAMMA, T3G
Human Chr (Location)		11q23; chr11:118215059-118224497 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CD3G

Alleles and phenotypes

All alleles(9) : Targeted(7) Gene trapped(2)
 

Mice homozygous for a knock-out allele exhibit decreased thymocyte number and T cell response.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	cell surface receptor signaling pathway, establishment or maintenance of cell polarity, ...
Component	alpha-beta T cell receptor complex, integral to membrane, ...
Function	protein binding, protein heterodimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) Genomic(9) cDNA(31)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034601 (Evidence)
Ensembl Gene Model	ENSMUSG00000002033 (Evidence)
Entrez Gene	12502 (Evidence)
UniGene	335106
DFCI	TC1584247
DoTS	DT.101369643, DT.492838, DT.525991
NIA Mouse Gene Index	U030789
PDB	1JBJ
Consensus CDS Project	CCDS23123.1
International Mouse Knockout Project Status	Cd3g

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034601	VEGA Gene Model | MGI Sequence Detail	10860	C57BL/6J
transcript	OTTMUST00000087780	VEGA | MGI Sequence Detail	1023	Not Applicable
polypeptide	OTTMUSP00000047791	VEGA | MGI Sequence Detail	182	Not Applicable

All sequences(42) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015484	CD3 protein, gamma/delta subunit
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR003110	Phosphorylated immunoreceptor signaling ITAM
Protein Ontology	PR:000001021	CD3 gamma

References

(Earliest) J:8651 Gold DP, et al., The gene encoding the epsilon subunit of the T3/T-cell receptor complex maps to chromosome 11 in humans and to chromosome 9 in mice. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1664-8
(Latest) J:177291 Hansen AK, et al., TCR down-regulation boosts T-cell-mediated cytotoxicity and protection against poxvirus infections. Eur J Immunol. 2011 Jul;41(7):1948-57
All references(70)

Other accession IDs

MGD-MRK-14698, MGD-MRK-1854, MGD-MRK-2212, MGD-MRK-2213