Cd3g MGI Mouse Gene Detail - MGI:88333 - CD3 antigen, gamma polypeptide

Symbol

Cd3g
Name

CD3 antigen, gamma polypeptide
Synonyms

Ctg-3, Ctg3, T3g

Feature Type

protein coding gene
IDs

MGI:88333
NCBI Gene: 12502
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:44880870-44891729 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM
Mapping Data

8 experiments

SNPs within 2kb

413 from dbSNP Build 142
Strain Annotations

19
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88333	protein coding gene	Chr9:44880870-44891729 (-)
129S1/SvImJ	ENSMUSG00200018067	protein coding gene	Chr9:41956879-41967693 (-)
A/J	ENSMUSG00195023894	protein coding gene	Chr9:41715986-41726864 (-)
AKR/J	ENSMUSG00220039457	protein coding gene	Chr9:41798509-41809387 (-)
BALB/cJ	ENSMUSG00180026911	protein coding gene	Chr9:41827701-41838583 (-)
C3H/HeJ	ENSMUSG00175015202	protein coding gene	Chr9:41839598-41850476 (-)
C57BL/6NJ	ENSMUSG00215013354	protein coding gene	Chr9:41801202-41812063 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032132	protein coding gene	Chr9:41843990-41855115 (-)
CAST/EiJ	ENSTCUG00005013918	protein coding gene	Chr9:41786810-41797659 (-)
CBA/J	ENSMUSG00210016667	protein coding gene	Chr9:41882244-41893113 (-)
DBA/2J	ENSMUSG00185010226	protein coding gene	Chr9:41954270-41965150 (-)
FVB/NJ	ENSMUSG00205039391	protein coding gene	Chr9:42197915-42208799 (-)
JF1/MsJ	ENSUMUG00000022886	protein coding gene	Chr9:41996630-42007444 (-)
LP/J	ENSMUSG00230041740	protein coding gene	Chr9:42247319-42258083 (-)
NOD/ShiLtJ	ENSMUSG00190018771	protein coding gene	Chr9:42033233-42044111 (-)
NZO/HlLtJ	ENSMUSG00225042722	protein coding gene	Chr9:42211494-42222354 (-)
PWK/PhJ	ENSLUMG00010018151	protein coding gene	Chr9:41955973-41967421 (-)
SPRET/EiJ	ENSMSPG00010009390	protein coding gene	Chr9:42719301-42729520 (-)
WSB/EiJ	ENSIUOG00005019945	protein coding gene	Chr9:41442935-41453588 (-)

Human Ortholog

CD3G, CD3 gamma subunit of T-cell receptor complex

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD3G, CD3 gamma subunit of T-cell receptor complex
Synonyms

CD3-GAMMA, CD3GAMMA, IMD17, T3G
Links

HGNC:1675

NCBI Gene ID: 917

UniProt: P09693
Chr Location

11q23.3; chr11:118344344-118355161 (+) GRCh38

MGI Vertebrate Homology

Cd3g stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CD3G
Gene Tree

Cd3g

Diseases

1 with human CD3G associations

				Human Disease	Mouse Models
				immunodeficiency 17 IDs immunodeficiency 17 DOID:0111973 OMIM:615607 ORDO:169082 UMLS_CUI:C3810107 UMLS_CUI:C4510864

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
4 phenotypes from multigenic genotypes
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

3
Gene trapped

2
Targeted

12
Genomic Mutations

4 involving Cd3g
Incidental Mutations

CvDC
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased thymocyte number and T cell response.

less

All GO Annotations

40
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

610
Tissues

4
cDNA Data

29
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cd3g

less

All Sequences

46
RefSeq

4
UniProt

4
CCDS

CCDS23123.1

Ensembl

ENSMUSG00000002033 (Evidence)
NCBI Gene

12502

			Length	Strain/Species	Flank
genomic	12502	NCBI Gene Model \| MGI Sequence Detail	10860	C57BL/6J	± kb
transcript	NM_009850	RefSeq \| MGI Sequence Detail	1019	C57BL/6
polypeptide	P11942	UniProt \| EBI \| MGI Sequence Detail	182	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000001021 CD3 gamma

(term hierarchy)
PDB

1JBJ
InterPro Domains

IPR032052 CD3 gamma/delta subunit, Ig-like domain

IPR015484 CD3 protein, epsilon/gamma/delta subunit

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003598 Immunoglobulin subtype 2

IPR003110 Phosphorylated immunoreceptor signalling ITAM
GlyGen

P11942 1 site

less

All nucleic 40

Genomic 9

cDNA 30

Primer pair 1

Antibodies 3

Microarray probesets 3

less

MGD-MRK-14698, MGD-MRK-1854, MGD-MRK-2212, MGD-MRK-2213

Summaries

All 86

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 30
Earliest

J:8651 Gold DP, et al., The gene encoding the epsilon subunit of the T3/T-cell receptor complex maps to chromosome 11 in humans and to chromosome 9 in mice. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1664-8
Latest

J:359311 Lin F, et al., Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment. Cell. 2024 Nov 2;

TSS for Cd3g:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr89222	Chr9:44891737-44891753 (-)	-16 bp
Tssr89221	Chr9:44891688-44891735 (-)	17 bp
Tssr89220	Chr9:44891640-44891667 (-)	75 bp
Tssr89219	Chr9:44891628-44891639 (-)	95 bp
Tssr89218	Chr9:44885643-44885657 (-)	6,079 bp
Tssr89217	Chr9:44885537-44885548 (-)	6,186 bp
Tssr89216	Chr9:44881069-44881072 (-)	10,658 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24