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Cd3e
Gene Detail
 Symbol
Name
ID
Cd3e
CD3 antigen, epsilon polypeptide
MGI:88332
Synonyms CD3, CD3epsilon, T3e
Feature Type protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr9:44998743-45009590 bp, - strand
From VEGA annotation of GRCm38

  10848 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:586  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: T-cell surface glycoprotein CD3 delta chain
Gene Tree: Cd3e

Human
homologs
Human Homolog CD3E, CD3e molecule, epsilon (CD3-TCR complex)
NCBI Gene ID 916
neXtProt AC  NX_P07766
Human Synonyms  IMD18, T3E, TCRE
Human Chr (Location)  11q23; chr11:118304580-118316175 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD3E
Alleles
and
phenotypes
All alleles(8) : Chemically induced (ENU)(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous null for this mutation lack peripherial T cells and have a block of thymocyte development at the DN3 stage.
 
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process apoptotic signaling pathway, cell surface receptor signaling pathway, ...
Component alpha-beta T cell receptor complex, cell-cell junction, ...
Function protein binding, protein heterodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (21)    Tissues (12)    Images (12)
Theiler Stages: 16, 20, 22, 23, 24, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 11
RT-PCR 8
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(36) Genomic(10) cDNA(24) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016712 (Evidence)
Ensembl Gene ModelENSMUSG00000032093 (Evidence)
Entrez Gene12501 (Evidence)
UniGene210361
DFCITC1588586, TC1598036
DoTSDT.489703, DT.489704
NIA Mouse Gene IndexU030791
PDB1JBJ, 1XMW, 2K4F, 3R08
Consensus CDS ProjectCCDS23125.1
International Mouse Knockout Project StatusCd3e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016712 VEGA Gene Model | MGI Sequence Detail 10848 C57BL/6J ±  kb
transcript OTTMUST00000040500 VEGA | MGI Sequence Detail 1436 Not Applicable 
polypeptide OTTMUSP00000018104 VEGA | MGI Sequence Detail 189 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(3)
Polymorphisms RFLP(3) : SNPs within 2kb(180 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015484 CD3 protein, gamma/delta subunit
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR003110 Phosphorylated immunoreceptor signaling ITAM
Protein Ontology PR:000001020 CD3 epsilon
References (Earliest) J:8304 Gold DP, et al., Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex [published erratum appears in Nature 1986 Dec 18-31;324(6098):702]. Nature. 1986 May 22-28;321(6068):431-4
(Latest) J:209827 Borroto A, et al., Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo. J Immunol. 2014 Mar 1;192(5):2042-53
All references(227)
Other
accession IDs
MGD-MRK-14697, MGD-MRK-1853, MGI:2143086

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory