Cd3d
Gene Detail

Symbol Name ID

Cd3d CD3 antigen, delta polypeptide MGI:88331

STS

D9Mit23

Synonyms

T3d

Feature Type

protein coding gene

Genetic Map

Chromosome 9

24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr9:44981793-44987052 bp, + strand From Ensembl annotation of GRCm38   5260 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:585  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: T-cell surface glycoprotein CD3 delta chain
Gene Tree: Cd3d

Human homologs

Human Homolog		CD3D, CD3d molecule, delta (CD3-TCR complex)
NCBI Gene ID		915
neXtProt AC		NX_P04234
Human Synonyms		CD3-DELTA, T3D
Human Chr (Location)		11q23; chr11:118209789-118213459 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CD3D

Alleles and phenotypes

All alleles(9) : Targeted(4) Gene trapped(5)
 

Homozygotes for targeted null mutations exhibit impaired early thymic development, small numbers of peripheral TCR-alpha/beta+ T cells, and failure of T lymphocyte transition from double-positive to single-positive developmental stages.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cell surface receptor signaling pathway, positive thymic T cell selection, ...
Component	alpha-beta T cell receptor complex, integral to membrane, ...
Function	protein binding, protein heterodimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (7)    Tissues (1)    Images (7)
Theiler Stages: 23

Assay Type	Results
RNA in situ	7

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(9) cDNA(16) Primer pair(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000032094 (Evidence)
Entrez Gene	12500 (Evidence)
UniGene	4527
DFCI	TC1585431, TC1713675, TC1729237
DoTS	DT.489272, DT.94175744
NIA Mouse Gene Index	U010405
Consensus CDS Project	CCDS23124.1
International Mouse Knockout Project Status	Cd3d

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032094	Ensembl Gene Model | MGI Sequence Detail	5260	C57BL/6J
transcript	ENSMUST00000034602	Ensembl | MGI Sequence Detail	1323	Not Applicable
polypeptide	ENSMUSP00000034602	Ensembl | MGI Sequence Detail	173	Not Applicable

All sequences(34) RefSeq(2) UniProt(7)

Polymorphisms

All PCR and RFLP(4) : PCR(3) RFLP(1) SNPs(38 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015484	CD3 protein, gamma/delta subunit
InterPro	IPR015485	CD3 signaling complex delta subunit
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003110	Phosphorylated immunoreceptor signaling ITAM
Protein Ontology	PR:000001019	CD3 delta

References

(Earliest) J:7832 van den Elsen P, et al., Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein. Nature. 1985 Apr 11-17;314(6011):542-4
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(63)

Other accession IDs

MGD-MRK-14696, MGD-MRK-1852