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Cd3d Gene Detail
Summary
  • Symbol
    Cd3d
  • Name
    CD3 antigen, delta polypeptide
  • Synonyms
    T3d
  • Feature Type
    protein coding gene
  • IDs
    MGI:88331
    NCBI Gene: 12500
  • Gene Overview
    MyGene.info: CD3D
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44981769-44987052 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    12 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88331
protein coding gene Chr9:44981769-44987339 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034725
protein coding gene Chr9:43516692-43521952 (+)
A/J MGP_AJ_G0034706
protein coding gene Chr9:42294935-42306258 (+)
AKR/J MGP_AKRJ_G0034633
protein coding gene Chr9:43172615-43180247 (+)
BALB/cJ MGP_BALBcJ_G0034697
protein coding gene Chr9:42033621-42039276 (+)
C3H/HeJ MGP_C3HHeJ_G0034408
protein coding gene Chr9:43623510-43628971 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035218
protein coding gene Chr9:44797817-44803075 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032133
protein coding gene Chr9:41856481-41861833 (+)
CAST/EiJ MGP_CASTEiJ_G0033730
protein coding gene Chr9:43487164-43493946 (+)
CBA/J MGP_CBAJ_G0034380
protein coding gene Chr9:46430307-46438466 (+)
DBA/2J MGP_DBA2J_G0034539
protein coding gene Chr9:42189369-42194816 (+)
FVB/NJ MGP_FVBNJ_G0034480
protein coding gene Chr9:41451688-41456695 (+)
LP/J MGP_LPJ_G0034620
protein coding gene Chr9:43814107-43819367 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034524
protein coding gene Chr9:48267600-48272758 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035239
protein coding gene Chr9:43093565-43100452 (+)
PWK/PhJ MGP_PWKPhJ_G0033435
protein coding gene Chr9:42077342-42082923 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033271
protein coding gene Chr9:43385563-43393721 (+)
WSB/EiJ MGP_WSBEiJ_G0033843
protein coding gene Chr9:43121396-43127687 (+)



Homology
more
  • Human Ortholog
    CD3D, CD3d molecule
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CD3D, CD3d molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD3-DELTA, IMD19, T3D
  • Links
    NCBI Gene ID: 915
    neXtProt AC: NX_P04234
    UniProt: P04234

  • Chr Location
    11q23.3; chr11:118339074-118344233 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired early thymic development, small numbers of peripheral TCR-alpha/beta+ T cells, and failure of T lymphocyte transition from double-positive to single-positive developmental stages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12500 NCBI Gene Model | MGI Sequence Detail 5284 C57BL/6J ±  kb
transcript NM_013487 RefSeq | MGI Sequence Detail 1330 C57BL/6  
polypeptide P04235 UniProt | EBI | MGI Sequence Detail 173 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 9
    cDNA 17
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14696, MGD-MRK-1852
References
more
  • Summaries
    All 64
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 16
  • Earliest
    J:7832 van den Elsen P, et al., Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein. Nature. 1985 Apr 11-17;314(6011):542-4
  • Latest
    J:246980 He T, et al., The effects of immune protein CD3zeta development and degeneration of retinal neurons after optic nerve injury. PLoS One. 2017;12(4):e0175522

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory