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Cd3d Gene Detail
Summary
  • Symbol
    Cd3d
  • Name
    CD3 antigen, delta polypeptide
  • Synonyms
    T3d
  • Feature Type
    protein coding gene
  • IDs
    MGI:88331
    NCBI Gene: 12500
Location & Maps
more
  • Sequence Map
    Chr9:44981793-44987052 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5260 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CD3D, CD3d molecule
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CD3D, CD3d molecule
    Orthology source: HomoloGene
  • Synonyms
    CD3-DELTA, IMD19, T3D
  • Links
    NCBI Gene ID: 915
    neXtProt AC: NX_P04234

  • Chr Location
    11q23; chr11:118339074-118342744 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CD3D associations

Human Disease Mouse Models
       Immunodeficiency 19; IMD19   OMIM: 615617
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    5
  • Targeted
    4
  • Genomic Mutations
    1 involving Cd3d
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit impaired early thymic development, small numbers of peripheral TCR-alpha/beta+ T cells, and failure of T lymphocyte transition from double-positive to single-positive developmental stages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032094 Ensembl Gene Model | MGI Sequence Detail 5260 C57BL/6J ±  kb
transcript ENSMUST00000034602 Ensembl | MGI Sequence Detail 1323 Not Applicable  
polypeptide ENSMUSP00000034602 Ensembl | MGI Sequence Detail 173 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    76 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000001019 CD3 delta
  • InterPro Domains
    IPR032052 CD3 gamma/delta subunit, Ig-like domain
    IPR015484 CD3 protein, epsilon/gamma/delta subunit
    IPR015485 CD3 signalling complex delta subunit
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003110 Phosphorylated immunoreceptor signalling ITAM
Molecular
Reagents
less
  • All nucleic 27
    Genomic 9
    cDNA 16
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14696, MGD-MRK-1852
References
more
  • Summaries
    All 54
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:7832 van den Elsen P, et al., Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein. Nature. 1985 Apr 11-17;314(6011):542-4
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory