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Cd3d
Gene Detail
Symbol

Name
ID
Cd3d
CD3 antigen, delta polypeptide
MGI:88331
STS
Synonyms
T3d
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr9:44981793-44987052 bp, + strand
From Ensembl annotation of GRCm38

  5260 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:585  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: T-cell surface glycoprotein CD3 delta chain
Gene Tree: Cd3d

Human
homologs
Human Homolog CD3D, CD3d molecule, delta (CD3-TCR complex)
NCBI Gene ID 915
neXtProt AC  NX_P04234
Human Synonyms  CD3-DELTA, IMD19, T3D
Human Chr (Location)  11q23; chr11:118339074-118342744 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD3D
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Targeted(4)
Genomic Mutations involving Cd3d (1)
 
Homozygotes for targeted null mutations exhibit impaired early thymic development, small numbers of peripheral TCR-alpha/beta+ T cells, and failure of T lymphocyte transition from double-positive to single-positive developmental stages.
 
Interactions
Cd3d interacts with 66 markers (Mir16-2, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (7)    Tissues (1)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(9) cDNA(16) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000032094 (Evidence)
Entrez Gene12500 (Evidence)
UniGene4527
DFCITC1585431, TC1713675, TC1729237
DoTSDT.489272, DT.94175744
NIA Mouse Gene IndexU010405
Consensus CDS ProjectCCDS23124.1
International Mouse Knockout Project StatusCd3d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032094 Ensembl Gene Model | MGI Sequence Detail 5260 C57BL/6J ±  kb
transcript ENSMUST00000034602 Ensembl | MGI Sequence Detail 1323 Not Applicable 
polypeptide ENSMUSP00000034602 Ensembl | MGI Sequence Detail 173 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(13)
Polymorphisms
All PCR and RFLP(4) : PCR(3) RFLP(1) SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015484 CD3 protein, gamma/delta subunit
InterPro IPR015485 CD3 signaling complex delta subunit
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003110 Phosphorylated immunoreceptor signaling ITAM
Protein Ontology PR:000001019 CD3 delta
References
(Earliest) J:7832 van den Elsen P, et al., Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein. Nature. 1985 Apr 11-17;314(6011):542-4
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(60)
Other
accession IDs
MGD-MRK-14696, MGD-MRK-1852

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory