Cd37
Gene Detail

Symbol Name ID

Cd37 CD37 antigen MGI:88330

Synonyms

Tspan26

Feature Type

protein coding gene

Genetic Map

Chromosome 7

29.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:45233632-45239115 bp, - strand From VEGA annotation of GRCm38   5484 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20422  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tetraspanin
Gene Tree: Cd37

Human homologs

Human Homolog		CD37, CD37 molecule
NCBI Gene ID		951
neXtProt AC		NX_P11049
Human Synonyms		GP52-40, TSPAN26
Human Chr (Location)		19q13.3; chr19:49838677-49843863 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(130) : Targeted(4) Gene trapped(126)
 

Homozygous mutation of this gene results in reduced levels of IgG1 immunoglobulins and impaired antibody response to T cell dependent antigens.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	defense response to protozoan, negative regulation of cell proliferation, ...
Component	immunological synapse, integral to membrane, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (5)    Tissues (1)    Images (5)
Theiler Stages: 23

Assay Type	Results
RNA in situ	5

cDNA source data(48)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(51) Genomic(3) cDNA(48)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000025381 (Evidence)
Ensembl Gene Model	ENSMUSG00000030798 (Evidence)
Entrez Gene	12493 (Evidence)
UniGene	3689
DFCI	TC1580002, TC1591444
DoTS	DT.40159393, DT.492245, DT.97347368, DT.99851984, DT.99851986
NIA Mouse Gene Index	U028522
Consensus CDS Project	CCDS21237.1
International Mouse Knockout Project Status	Cd37

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025381	VEGA Gene Model | MGI Sequence Detail	5484	C57BL/6J
transcript	OTTMUST00000062491	VEGA | MGI Sequence Detail	1268	Not Applicable
polypeptide	OTTMUSP00000030810	VEGA | MGI Sequence Detail	303	Not Applicable

All sequences(59) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(2) : SNPs(39 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000301	Tetraspanin
InterPro	IPR018503	Tetraspanin, conserved site
InterPro	IPR008952	Tetraspanin, EC2 domain
InterPro	IPR018499	Tetraspanin/Peripherin
Protein Ontology	PR:000005170	CD37 molecule

References

(Earliest) J:12638 Wright MD, et al., Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication. Int Immunol. 1993 Feb;5(2):209-16
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(42)

Other accession IDs

MGD-MRK-1850