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Cd34
Gene Detail
 Symbol
Name
ID
Cd34
CD34 antigen
MGI:88329
Feature Type protein coding gene
Genetic Map
Chromosome 1
98.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:194938821-194961292 bp, + strand
From NCBI annotation of GRCm38

  22472 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1343  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: sialomucin CD34
Gene Tree: Cd34

Human
homologs
Human Homolog CD34, CD34 molecule
NCBI Gene ID 947
neXtProt AC  NX_P28906
Human Chr (Location)  1q32; chr1:207886538-207911338 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show decreased splenocyte number and hematopoietic defects. Homozygotes for another null allele show reduced eosinophil accumulation after allergen exposure, impaired TPA-induced hair follicle stem cell activation and reduced incidence of chemically-induced skin tumors.
 
Interactions
Cd34 interacts with 231 markers (Mir10a, Mir10b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process cell adhesion, endothelial cell proliferation, ...
Component apical plasma membrane, basal plasma membrane, ...
Function carbohydrate binding, sulfate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (110 records)
Data Summary: Results (451)    Tissues (255)    Images (63)
Theiler Stages: 4, 10, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 29
RNA in situ 364
RT-PCR 58
cDNA source data(121)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(131) Genomic(4) cDNA(123) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000016494 (Evidence)
Entrez Gene12490 (Evidence)
UniGene29798
DFCITC1574057, TC1587279, TC1751545
DoTSDT.101282823, DT.102540388, DT.103563024, DT.494315, DT.91373880, DT.94202748
NIA Mouse Gene IndexU001314
Consensus CDS ProjectCCDS15640.1, CCDS48490.1
International Mouse Knockout Project StatusCd34
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12490 NCBI Gene Model | MGI Sequence Detail 22472 C57BL/6J ±  kb
transcript NM_001111059 RefSeq | MGI Sequence Detail 2621 C57BL/6 
polypeptide Q64314 UniProt | EBI | MGI Sequence Detail 382 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008083 CD34 antigen
InterPro IPR013836 CD34/Podocalyxin
Protein Ontology PR:000001003 CD34 molecule
Graphical View of Protein Domain Structure
References (Earliest) J:2996 Howell SM, et al., Localisation of the gene coding for the haemopoietic stem cell antigen CD34 to chromosome 1q32. Hum Genet. 1991 Sep;87(5):625-7
(Latest) J:210584 van Berlo JH, et al., c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014 May 15;509(7500):337-41
All references(170)
Other
accession IDs
MGD-MRK-1849, MGI:2138487

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory