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Cd34 Gene Detail
Summary
  • Symbol
    Cd34
  • Name
    CD34 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:88329
    NCBI Gene: 12490
  • Gene Overview
    MyGene.info: CD34
Location & Maps
more
  • Sequence Map
    Chr1:194938819-194961279 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22461 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 98.38 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CD34, CD34 molecule
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CD34, CD34 molecule
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 947
    neXtProt AC: NX_P28906

  • Chr Location
    1q32; chr1:207881028-207911338 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    6
  • Transgenic
    2
  • Incidental Mutations
Homozygotes for a null allele show decreased splenocyte number and hematopoietic defects. Homozygotes for another null allele show reduced eosinophil accumulation after allergen exposure, impaired TPA-induced hair follicle stem cell activation and reduced incidence of chemically-induced skin tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050886 VEGA Gene Model | MGI Sequence Detail 22461 C57BL/6J ±  kb
transcript OTTMUST00000128964 VEGA | MGI Sequence Detail 2454 Not Applicable  
polypeptide OTTMUSP00000069339 VEGA | MGI Sequence Detail 382 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    78 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 131
    Genomic 4
    cDNA 123
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1849, MGI:2138487
References
more
  • Summaries
    All 184
    Developmental Gene Expression 125
    Gene Ontology 17
    Phenotypes 16
  • Earliest
    J:2996 Howell SM, et al., Localisation of the gene coding for the haemopoietic stem cell antigen CD34 to chromosome 1q32. Hum Genet. 1991 Sep;87(5):625-7
  • Latest
    J:231834 Vanhoutteghem A, et al., The importance of basonuclin 2 in adult mice and its relation to basonuclin 1. Mech Dev. 2016 May;140:53-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory