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Cd34
Gene Detail
Symbol

Name
ID
Cd34
CD34 antigen
MGI:88329
Feature Type
protein coding gene
Genetic Map
Chromosome 1
98.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:194938819-194961279 bp, + strand
From VEGA annotation of GRCm38

  22461 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1343  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: CD34
Protein SuperFamily: sialomucin CD34
Gene Tree: Cd34

Human
homologs
CD34, CD34 molecule
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 947
neXtProt AC: NX_P28906

Human Chr (Location): 1q32; chr1:207881028-207911338 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show decreased splenocyte number and hematopoietic defects. Homozygotes for another null allele show reduced eosinophil accumulation after allergen exposure, impaired TPA-induced hair follicle stem cell activation and reduced incidence of chemically-induced skin tumors.
 
Interactions
Cd34 interacts with 230 markers (Mir10a, Mir10b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process cell adhesion, endothelial cell proliferation, ...
Component apical plasma membrane, basal plasma membrane, ...
Function carbohydrate binding, sulfate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (119 records)
Data Summary: Results (459)    Tissues (261)    Images (71)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 37
RNA in situ 364
RT-PCR 58
cDNA source data(121)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC779603    NEW 
Molecular
reagents
All nucleic(131) Genomic(4) cDNA(123) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000050886 (Evidence)
Ensembl Gene Model ENSMUSG00000016494 (Evidence)
Entrez Gene 12490 (Evidence)
UniGene 29798
DFCI TC1574057, TC1587279, TC1751545
DoTS DT.101282823, DT.102540388, DT.103563024, DT.494315, DT.91373880, DT.94202748
NIA Mouse Gene Index U001314
Consensus CDS Project CCDS15640.1, CCDS48490.1
International Mouse Phenotyping Consortium Status Cd34
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050886 VEGA Gene Model | MGI Sequence Detail 22461 C57BL/6J ±  kb
transcript OTTMUST00000128964 VEGA | MGI Sequence Detail 2454 Not Applicable 
polypeptide OTTMUSP00000069339 VEGA | MGI Sequence Detail 382 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(4) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008083 CD34 antigen
InterPro IPR013836 CD34/Podocalyxin
Protein Ontology PR:000001003 CD34 molecule
References
(Earliest) J:2996 Howell SM, et al., Localisation of the gene coding for the haemopoietic stem cell antigen CD34 to chromosome 1q32. Hum Genet. 1991 Sep;87(5):625-7
(Latest) J:215166 Ayala de la Pena F, et al., Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects. PLoS One. 2014;9(4):e95888
All references(178)
Other
accession IDs
MGD-MRK-1849, MGI:2138487

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory